5XRB

Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SSRF BEAMLINE BL17U1
Synchrotron site	SSRF
Beamline	BL17U1
Temperature [K]	100
Detector technology	CCD
Collection date	2012-01-03
Detector	ADSC QUANTUM 315r
Wavelength(s)	0.97915
Spacegroup name	I 2 2 2
Unit cell lengths	67.446, 90.701, 98.277
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	35.145 - 1.650
R-factor	0.1877
Rwork	0.187
R-free	0.19770
RMSD bond length	0.006
RMSD bond angle	1.008
Data scaling software	HKL-2000
Refinement software	PHENIX (1.6.2_432)

Data quality characteristics

	Overall
Low resolution limit [Å]	35.145
High resolution limit [Å]	1.650
Number of reflections	36575
<I/σ(I)>	63.3
Completeness [%]	100.0
Redundancy	14.5

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP