5HOA

Crystal structure of c-Met L1195V in complex with SAR125844

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID14-4
Synchrotron site	ESRF
Beamline	ID14-4
Temperature [K]	100
Detector technology	CCD
Collection date	2009-01-28
Detector	ADSC QUANTUM 315
Wavelength(s)	0.9185
Spacegroup name	P 21 21 21
Unit cell lengths	42.880, 47.550, 153.650
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	31.850 - 2.140
Data reduction software	MOSFLM
Data scaling software	SCALA
Phasing software	AMoRE
Refinement software	REFMAC

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	47.570	2.250
High resolution limit [Å]	2.140	2.140
Number of reflections	58760
<I/σ(I)>	10.6	2.6
Completeness [%]	98.3	99.3
Redundancy	3.3	3.3

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP	8.5	277	Tris 100 mM, MPD 24%, pH8.5