3ZNO

IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	ROTATING ANODE
Source details	RIGAKU FR-E
Temperature [K]	100
Detector technology	CCD
Detector	RIGAKU SATURN
Spacegroup name	P 21 21 21
Unit cell lengths	44.031, 61.056, 259.723
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	39.250 - 2.300
R-factor	0.2209
Rwork	0.217
R-free	0.28910
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	2du8
RMSD bond length	0.010
RMSD bond angle	1.160
Data reduction software	d*TREK
Phasing software	MOLREP
Refinement software	BUSTER (2.11.1)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	64.930	2.380
High resolution limit [Å]	2.300	2.300
Rmerge	0.110	0.400
Number of reflections	29214
<I/σ(I)>	8.9	2.1
Completeness [%]	90.6	94.1
Redundancy	4.21	2.87

Crystallization Conditions

crystal ID	method	pH	temperature	details
1