3ZNN
IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | ROTATING ANODE |
| Source details | RIGAKU FR-E |
| Temperature [K] | 100 |
| Detector technology | CCD |
| Detector | RIGAKU SATURN |
| Spacegroup name | P 1 21 1 |
| Unit cell lengths | 44.830, 78.680, 99.960 |
| Unit cell angles | 90.00, 92.84, 90.00 |
Refinement procedure
| Resolution | 15.540 - 1.900 |
| R-factor | 0.2102 |
| Rwork | 0.207 |
| R-free | 0.26310 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | 2du8 |
| RMSD bond length | 0.010 |
| RMSD bond angle | 1.140 |
| Data reduction software | d*TREK |
| Phasing software | MOLREP |
| Refinement software | BUSTER (2.11.1) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 19.460 | 1.970 |
| High resolution limit [Å] | 1.900 | 1.900 |
| Rmerge | 0.050 | 0.330 |
| Number of reflections | 51647 | |
| <I/σ(I)> | 7.1 | 1.8 |
| Completeness [%] | 94.4 | 93.9 |
| Redundancy | 1.73 | 1.67 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 |
