3F66

Human c-Met Kinase in complex with quinoxaline inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SLS BEAMLINE X06SA
Synchrotron site	SLS
Beamline	X06SA
Temperature [K]	100
Detector technology	PIXEL
Collection date	2007-11-01
Detector	PSI PILATUS 6M
Wavelength(s)	1.00
Spacegroup name	P 1
Unit cell lengths	47.377, 47.587, 75.600
Unit cell angles	100.70, 103.62, 98.29

Refinement procedure

Resolution	20.000 - 1.400
Rwork	0.168
R-free	0.22491
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.018
RMSD bond angle	1.682
Data reduction software	XDS
Data scaling software	XSCALE
Refinement software	REFMAC (5.2.0005)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	24.560	1.470
High resolution limit [Å]	1.400	1.400
Rmerge	0.051	0.516
Number of reflections	107820
<I/σ(I)>	10.59	2.01
Completeness [%]	88.5	67

Crystallization Conditions

crystal ID	method	pH	temperature	details
1