2W1E

Structure determination of Aurora Kinase in complex with inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID14-4
Synchrotron site	ESRF
Beamline	ID14-4
Temperature [K]	100
Detector technology	CCD
Detector	ADSC CCD
Spacegroup name	P 61 2 2
Unit cell lengths	83.086, 83.086, 168.133
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	20.790 - 2.930
R-factor	0.237
Rwork	0.233
R-free	0.30200
Structure solution method	OTHER
Starting model (for MR)	NONE
RMSD bond length	0.012
RMSD bond angle	1.437
Refinement software	REFMAC (5.4.0069A)

Data quality characteristics

	Overall
Low resolution limit [Å]	20.790
High resolution limit [Å]	2.930
Rmerge	0.050
Number of reflections	7464
<I/σ(I)>	5.8
Completeness [%]	99.6
Redundancy	3.9

Crystallization Conditions

crystal ID	method	pH	temperature	details
1