2V0D
Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | ROTATING ANODE |
| Source details | RIGAKU RUH3R |
| Temperature [K] | 110 |
| Detector technology | IMAGE PLATE |
| Collection date | 2003-06-16 |
| Detector | RIGAKU MSC |
| Spacegroup name | P 21 21 21 |
| Unit cell lengths | 53.459, 71.850, 72.011 |
| Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
| Resolution | 8.000 - 2.200 |
| R-factor | 0.197 |
| Rwork | 0.193 |
| R-free | 0.28600 |
| Structure solution method | OTHER |
| RMSD bond length | 0.018 |
| RMSD bond angle | 1.774 |
| Data reduction software | d*TREK |
| Data scaling software | d*TREK |
| Refinement software | REFMAC (5.2) |
Data quality characteristics
| Overall | |
| Low resolution limit [Å] | 30.000 |
| High resolution limit [Å] | 2.000 |
| Rmerge | 0.080 |
| Number of reflections | 18985 |
| <I/σ(I)> | 7.8 |
| Completeness [%] | 98.1 |
| Redundancy | 2.3 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, HANGING DROP | 7 | VAPOR DIFFUSION HANGING DROP, ROOM TEMPERATURE, PEG3350, HEPES PH7.2, AMMONIUM ACETATE, pH 7.00 |
