2IWU

Analogues of radicicol bound to the ATP-binding site of Hsp90

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID14-2
Synchrotron site	ESRF
Beamline	ID14-2
Temperature [K]	100
Detector technology	CCD
Collection date	2006-03-17
Detector	ADSC CCD
Spacegroup name	P 43 2 2
Unit cell lengths	74.642, 74.642, 110.541
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	50.000 - 2.800
Rwork	0.232
R-free	0.29100
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	1ah6
Data reduction software	MOSFLM
Data scaling software	SCALA
Refinement software	PHENIX

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	50.000	2.950
High resolution limit [Å]	2.800	2.800
Rmerge	0.180	0.530
Number of reflections	7940
<I/σ(I)>	3.2	1.3
Completeness [%]	98.1	99.5
Redundancy	3.5	3.6

Crystallization Conditions

crystal ID	method	pH	temperature	details
1