2YIS
triazolopyridine inhibitors of p38 kinase.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | ESRF |
| Synchrotron site | ESRF |
| Temperature [K] | 100 |
| Spacegroup name | P 21 21 21 |
| Unit cell lengths | 65.450, 74.100, 77.140 |
| Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
| Resolution | 23.430 - 2.000 |
| R-factor | 0.2163 |
| Rwork | 0.214 |
| R-free | 0.25490 |
| Structure solution method | OTHER |
| Starting model (for MR) | NONE |
| RMSD bond length | 0.010 |
| RMSD bond angle | 1.110 |
| Refinement software | BUSTER (2.9.6) |
Data quality characteristics
| Overall | |
| Low resolution limit [Å] | 23.500 |
| High resolution limit [Å] | 2.000 |
| Rmerge | 0.060 |
| Number of reflections | 25518 |
| <I/σ(I)> | 15 |
| Completeness [%] | 98.0 |
| Redundancy | 3.7 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 |
