1Y6B
Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | APS BEAMLINE 17-ID |
| Synchrotron site | APS |
| Beamline | 17-ID |
| Wavelength(s) | 1.0 |
| Spacegroup name | P 21 21 21 |
| Unit cell lengths | 37.544, 94.333, 96.767 |
| Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
| Resolution | 16.600 - 2.100 |
| R-factor | 0.19385 |
| Rwork | 0.192 |
| R-free | 0.23588 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.016 |
| RMSD bond angle | 1.539 |
| Data scaling software | SCALEPACK |
| Phasing software | AMoRE |
| Refinement software | REFMAC (5.2.0005) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 20.000 | 2.170 |
| High resolution limit [Å] | 2.100 | 2.100 |
| Rmerge | 0.045 | 0.355 |
| Number of reflections | 20768 | |
| <I/σ(I)> | 42.9 | 5.46 |
| Completeness [%] | 99.5 | 99.1 |
| Redundancy | 6.79 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 |
