1TTC

THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL30MET VARIANT TO 1.7 ANGSTROMS RESOLUTION

Experimental procedure

Spacegroup name	P 21 21 2
Unit cell lengths	44.010, 86.290, 65.370
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	5.800 - 1.700
R-factor	0.179
RMSD bond length	0.022
RMSD bond angle	0.038 *
Refinement software	PROLSQ

Data quality characteristics

	Overall
Rmerge	0.063 *
Number of reflections	25770 *

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	Vapor diffusion *	5.3 *	22 *

Crystallization Reagents in Literatures

ID	crystal ID	solution	reagent name	concentration (unit)	details
1	1	drop	protein	10 (mg/ml)
2	1	reservoir	ammonium sulfate	40 (%)
3	1	reservoir	citrate	200 (mM)