1INW

A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

Experimental procedure

Spacegroup name	C 2 2 21
Unit cell lengths	122.080, 141.670, 141.870
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	8.000 - 2.400
R-factor	0.206
Rwork	0.206
RMSD bond length	0.015
RMSD bond angle	2.060 *
Phasing software	X-PLOR
Refinement software	X-PLOR

Data quality characteristics

	Overall
Low resolution limit [Å]	9999.000 *
High resolution limit [Å]	2.420 *
Rmerge	0.074 *
Number of reflections	37401
Completeness [%]	76.0 *
Redundancy	1.45 *

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	Vapor diffusion, hanging drop *	7.2 *		NATIVE CRYSTALS SOAKED IN 10MM APANA SOLUTION, PH 7.2.

Crystallization Reagents in Literatures

ID	crystal ID	solution	reagent name	concentration (unit)	details
1	1	reservoir	phosphate	0.1 (M)
2	1	reservoir		0.15 (M)
3	1	reservoir	PEG3350	12.5 (%(w/v))