9OTS
 
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9OTW
 | | Influenza A Virus Nucleoprotein(8-498)NP complex with 5-(4-{[(2R)-6,6-dimethyl-1,4-dioxan-2-yl]methoxy}phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (compound 13) | | Descriptor: | 5-(4-{[(2R)-6,6-dimethyl-1,4-dioxan-2-yl]methoxy}phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide, MAGNESIUM ION, Nucleoprotein | | Authors: | Mamo, M. | | Deposit date: | 2025-05-27 | | Release date: | 2025-08-06 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.244 Å) | | Cite: | Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein-Protein Interaction.
J.Med.Chem., 68, 2025
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9OUC
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9OUG
 | | Influenza A Virus Nucleoprotein(8-498)NP complex with rac-5-(4-(((2R,6R)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl)methoxy)phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (Compound 20) | | Descriptor: | 5-(4-{[(2R,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy}phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide, Nucleoprotein | | Authors: | Mamo, M. | | Deposit date: | 2025-05-28 | | Release date: | 2025-08-06 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein-Protein Interaction.
J.Med.Chem., 68, 2025
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9Q88
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9Q8Y
 | | Structure of RNF38 RING with linchpin mutant R454Y in complex with Ubch5B-Ub | | Descriptor: | Isoform 2 of E3 ubiquitin-protein ligase RNF38, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 D2, ... | | Authors: | Gabrielsen, M, Buetow, L, Huang, D.T. | | Deposit date: | 2025-02-25 | | Release date: | 2025-07-30 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue.
Life Sci Alliance, 8, 2025
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9QNR
 | | Cryo-EM structure of TTYH3 in GDN after incubation with ApoE, map2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein tweety homolog 3 | | Authors: | Sukalskaia, A, Pugnetti, A, Dutzler, R, Plochberger, B, Weber, F, Karner, A. | | Deposit date: | 2025-03-25 | | Release date: | 2025-05-21 | | Last modified: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Interactions between TTYH2 and APOE facilitate endosomal lipid transfer.
Nature, 644, 2025
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9QQR
 | | S.aureus ClpC decameric resting state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpC | | Authors: | Engelhardt, L, Carroni, M. | | Deposit date: | 2025-04-02 | | Release date: | 2025-07-30 | | Last modified: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptide
To Be Published
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9R59
 | | Crystal structure of MAPKAPK2 with a covalent compound GCL334 targeting lysine | | Descriptor: | 5-[3-[bis(oxidanyl)-$l^{3}-sulfanyl]oxy-4-chloranyl-phenyl]-~{N}-(4-piperazin-1-ylphenyl)-~{N}-(pyridin-2-ylmethyl)furan-2-carboxamide, MAP kinase-activated protein kinase 2 | | Authors: | Wang, G.Q, Hillebrand, L, Gehringer, M, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2025-05-08 | | Release date: | 2025-07-30 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2.
Rsc Med Chem, 2025
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9U50
 | | GDP-bound KRAS G12V in complex with MCB-294 | | Descriptor: | (3~{R})-1-[2-[[(8~{S})-6-[bis(fluoranyl)methylidene]-2,3,5,7-tetrahydro-1~{H}-pyrrolizin-8-yl]methoxy]-7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-pyrido[4,3-d]pyrimidin-4-yl]-3-methyl-piperidin-3-ol, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | | Authors: | Li, K.K, Guo, R.-T. | | Deposit date: | 2025-03-20 | | Release date: | 2025-07-30 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers.
Cancer Cell, 2025
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9U5T
 | | GDP-bound KRAS G12D in complex with MCB-294 | | Descriptor: | (3~{R})-1-[2-[[(8~{S})-6-[bis(fluoranyl)methylidene]-2,3,5,7-tetrahydro-1~{H}-pyrrolizin-8-yl]methoxy]-7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-pyrido[4,3-d]pyrimidin-4-yl]-3-methyl-piperidin-3-ol, DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Li, K.K, Guo, R.-T. | | Deposit date: | 2025-03-21 | | Release date: | 2025-07-30 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers.
Cancer Cell, 2025
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9USB
 | | GppNHp-bound KRAS G12D in complex with MCB-294 | | Descriptor: | (3~{R})-1-[2-[[(8~{S})-6-[bis(fluoranyl)methylidene]-2,3,5,7-tetrahydro-1~{H}-pyrrolizin-8-yl]methoxy]-7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-pyrido[4,3-d]pyrimidin-4-yl]-3-methyl-piperidin-3-ol, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | | Authors: | Li, K.K, Guo, R.-T, Huang, J.W. | | Deposit date: | 2025-05-01 | | Release date: | 2025-07-30 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers.
Cancer Cell, 2025
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9V7V
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9VN5
 | | Structure of WDR5 in complex with MBD3C R43K | | Descriptor: | Methyl-CpG binding domain protein 3, WD repeat-containing protein 5 | | Authors: | Xu, L, Yang, Y. | | Deposit date: | 2025-06-30 | | Release date: | 2025-08-13 | | Last modified: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural insights into lysine-mediated WIN site recognition reveal an alternative "AK" motif for WDR5 binding.
Biochem.Biophys.Res.Commun., 779, 2025
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