8KAR
 
 | | Glutamate dehydrogenase-AKG | | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, Glutamate dehydrogenase, ... | | Authors: | Sakuraba, H, Ohshima, T. | | Deposit date: | 2023-08-03 | | Release date: | 2024-08-07 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Structural insight into the unique substrate specificity of glutamate dehydrogenase from Saccharolobus solfataricus.
Extremophiles, 29, 2025
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8Q4S
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8Q60
 | | Racemic crystal structure of a synthetic DNA Hairpin with diquinoline linker. | | Descriptor: | 4-[8-(aminomethyl)-2-[[5-(3-oxidanylpropyl)quinolin-8-yl]carbamoyl]quinolin-4-yl]butyl dihydrogen phosphite, 5'-D(*GP*TP*TP*TP*TP*G)-3', DNA (5'-D(CP*AP*AP*AP*AP*C)-3'), ... | | Authors: | Mandal, P.K, Loos, M, Xu, F, Huc, I. | | Deposit date: | 2023-08-10 | | Release date: | 2025-02-19 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Interfacing B-DNA and DNA Mimic Foldamers.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8QNZ
 | | OXA-48 with carbamylated Lys73 in complex with hydrolysed Imipenem and bromide ion competing for binding with Arg250 at neutral pH | | Descriptor: | (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, 1-BUTANOL, BROMIDE ION, ... | | Authors: | Zhou, Q, He, Y, Jin, Y. | | Deposit date: | 2023-09-27 | | Release date: | 2023-11-08 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity.
Acs Cent.Sci., 9, 2023
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8QOB
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8RUY
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8S4M
 | | Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with an inhibitor | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, Steroid C26-monooxygenase, ... | | Authors: | Snee, M, Kavanagh, M, Levy, C. | | Deposit date: | 2024-02-21 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.
J.Med.Chem., 68, 2025
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8S53
 | | X-ray crystal structure of CYP142 from Mycobacterium tuberculosis in complex with a fragment bound in two poses | | Descriptor: | 4-benzylpyridine, PROTOPORPHYRIN IX CONTAINING FE, Steroid C26-monooxygenase | | Authors: | Snee, M, Kavanagh, M, Levy, C, Leys, D. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-29 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.
J.Med.Chem., 68, 2025
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8US0
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8V5V
 | | Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2,Fibritin, ... | | Authors: | Olmedillas, E, Diaz, R, Hastie, K, Ollmann-Saphire, E. | | Deposit date: | 2023-12-01 | | Release date: | 2024-12-18 | | Last modified: | 2025-08-06 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation.
Cell Rep, 44, 2025
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8VDO
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8VDP
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8VDQ
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8VDR
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8VQV
 | | Structure of S. odontolytica ZTP riboswitch bound to m-1-pyridinyl-AICA | | Descriptor: | 5-amino-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide, MAGNESIUM ION, RNA (64-MER) | | Authors: | Jones, C.P, Ferre D'Amare, A.R. | | Deposit date: | 2024-01-19 | | Release date: | 2025-06-11 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Machine Learning-Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8VUK
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8VVJ
 | | Structure of S. odontolytica ZTP riboswitch bound to m-1-pyridinyl-AICA | | Descriptor: | (1M)-5-amino-1-(1,8-naphthyridin-3-yl)-1H-imidazole-4-carboxamide, MAGNESIUM ION, RNA (64-MER) | | Authors: | Jones, C.P, Ferre D'Amare, A.R. | | Deposit date: | 2024-01-31 | | Release date: | 2025-06-11 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Machine Learning-Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands.
Angew.Chem.Int.Ed.Engl., 64, 2025
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8X2O
 | | RIPK2 in complex with K252 | | Descriptor: | Receptor-interacting serine/threonine-protein kinase 2, ~{N}-[(1~{R})-4-[4-[(6-fluoranyl-1,3-benzothiazol-5-yl)amino]thieno[2,3-d]pyrimidin-6-yl]cyclohex-3-en-1-yl]cyclopropanecarboxamide | | Authors: | Yang, J.H, Yang, J.H. | | Deposit date: | 2023-11-10 | | Release date: | 2024-11-13 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury.
Acta Pharm Sin B, 15, 2025
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8XMK
 | | Local refinement of SRCR5-9 domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Scavenger receptor cysteine-rich type 1 protein M130 | | Authors: | Xu, H, Su, X.D. | | Deposit date: | 2023-12-27 | | Release date: | 2025-01-01 | | Last modified: | 2025-08-06 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands.
Nat Commun, 16, 2025
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8XMP
 | | Structure of CD163 in complex with Hb-Hp | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Xu, H, Su, X.D. | | Deposit date: | 2023-12-27 | | Release date: | 2025-01-01 | | Last modified: | 2025-08-06 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands.
Nat Commun, 16, 2025
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8XMQ
 | | Structure of dimeric CD163 in complex with Hb-Hp | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Xu, H, Su, X.D. | | Deposit date: | 2023-12-27 | | Release date: | 2025-01-01 | | Last modified: | 2025-08-06 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands.
Nat Commun, 16, 2025
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8XMW
 | | Local refinement of Hb-Hp bind to CD163 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Xu, H, Su, X.D. | | Deposit date: | 2023-12-28 | | Release date: | 2025-01-01 | | Last modified: | 2025-08-06 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands.
Nat Commun, 16, 2025
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8XUJ
 | | Structure of beta-1,2-glucanase from Endozoicomonas elysicola (EeSGL1, ligand-free) | | Descriptor: | Membrane protein | | Authors: | Nakajima, M, Motouchi, S, Nakai, H. | | Deposit date: | 2024-01-13 | | Release date: | 2025-01-22 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | New glycoside hydrolase families of beta-1,2-glucanases.
Protein Sci., 34, 2025
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8XUK
 | | Structure of beta-1,2-glucanase from Photobacterium gaetbulicola (PgSGL3, ligand-free) | | Descriptor: | CHLORIDE ION, H744_1c0222 | | Authors: | Nakajima, M, Motouchi, S, Nakai, H. | | Deposit date: | 2024-01-13 | | Release date: | 2025-01-22 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | New glycoside hydrolase families of beta-1,2-glucanases.
Protein Sci., 34, 2025
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8XUL
 | | Structure of beta-1,2-glucanase from Xanthomonas campestris pv. campestris (beta-1,2-glucoheptasaccharide complex)-E239Q mutant | | Descriptor: | XCC2207, beta-D-glucopyranose-(1-2)-beta-D-glucopyranose-(1-2)-beta-D-glucopyranose-(1-2)-beta-D-glucopyranose-(1-2)-beta-D-glucopyranose-(1-2)-beta-D-glucopyranose-(1-2)-beta-D-glucopyranose | | Authors: | Nakajima, M, Motouchi, S, Nakai, H. | | Deposit date: | 2024-01-13 | | Release date: | 2025-01-22 | | Last modified: | 2025-08-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | New glycoside hydrolase families of beta-1,2-glucanases.
Protein Sci., 34, 2025
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