8UGO
 
 | | Structure of the complex between Human LIAS and H-protein in the presence of 5'-deoxyadenosine | | Descriptor: | 5'-DEOXYADENOSINE, 6-THIOOCTANOIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Esakova, O.A, Warui, D.M, Neti, S.S, Alumasa, J.N, Booker, S.J. | | Deposit date: | 2023-10-05 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural basis for the mechanism of the human lipoyl synthase (LIAS) and its complex with the H-protein
To Be Published
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8UUI
 | | X-ray structure of Interleukin-23 in complex with peptide 23-446 | | Descriptor: | Interleukin-12 subunit beta, Interleukin-23 subunit alpha, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Joseph, J.S, Sridhar, V.S, Liu, M, Hu, Y, Gatchalian, J. | | Deposit date: | 2023-11-01 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Identification of an Induced Orthosteric Pocket in IL-23: A New Avenue for Non-biological Therapeutic Targeting.
Acs Chem.Biol., 2025
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8VWO
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8YXQ
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8YXY
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9C19
 | | Structure of human LIAS | | Descriptor: | 6-THIOOCTANOIC ACID, FE3-S4 CLUSTER, Glycine cleavage system H protein, ... | | Authors: | Esakova, O.A, Warui, D.M, Neti, S.S, Alumasa, J.N, Booker, S.J. | | Deposit date: | 2024-05-28 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Structural basis for the mechanism of the human lipoyl synthase (LIAS) and its complex with the H-protein
To Be Published
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9C23
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9C25
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9C26
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9CIR
 | | Crystal structure of pyrophosphate-dependent phosphofructokinase from Candidatus Prometheoarchaeum syntrophicum | | Descriptor: | 6-phosphofructokinase | | Authors: | Compton, J.A, Yosaatmadja, Y, Bashiri, G, Vickers, C.J, Patrick, W.M. | | Deposit date: | 2024-07-04 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure and function of an unusual, multi-tasking phosphofructokinase from an Asgard archaeon
To Be Published
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9CIS
 | | Crystal structure of the pyrophosphate-dependent phosphofructokinase from Candidatus Prometheoarchaeum syntrophicum with fructose 6-phosphate | | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructokinase | | Authors: | Compton, J.A, Yosaatmadja, Y, Bashiri, G, Vickers, C.J, Patrick, W.M. | | Deposit date: | 2024-07-04 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structure and function of an unusual, multi-tasking phosphofructokinase from an Asgard archaeon
To Be Published
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9CIT
 | | Crystal structure of pyrophosphate-dependent phosphofructokinase from Candidatus Prometheoarchaeum syntrophicum with phosphoenolpyruvate, phosphate and Mg2+ | | Descriptor: | 6-phosphofructokinase, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Compton, J.A, Yosaatmadja, Y, Bashiri, G, Vickers, C.J, Patrick, W.M. | | Deposit date: | 2024-07-04 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Structure and function of an unusual, multi-tasking phosphofructokinase from an Asgard archaeon
To Be Published
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9CIV
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9CIY
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9CJO
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9CJP
 | | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir | | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Nirmatrelvir
To Be Published
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9CJQ
 | | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir | | Descriptor: | 1,2-ETHANEDIOL, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, main protease | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease quadruple mutants in complex with Ensitrelvir
To Be Published
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9CJR
 | | X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir | | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, CHLORIDE ION, ... | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease double mutants in complex with Ensitrelvir
To Be Published
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9CJS
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9CJT
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9CJU
 | | Structure of SARS-CoV-2 main protease in complex with Bofutrelvir in orthorhombic form | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Non-structural protein 7, ... | | Authors: | Esler, M.A, Shi, K, Harris, R.S, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | To be published
To Be Published
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9CJV
 | | X-ray crystal structure of SARS-CoV-2 main protease complex with Bofutrelvir | | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | | Authors: | Esler, M.A, Shi, K, Aihara, H. | | Deposit date: | 2024-07-07 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | X-ray crystal structure of SARS-CoV-2 main protease complex with Bofutrelvir
To Be Published
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9CR9
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9CV2
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9CV3
 | | Crystal structure of the metallo-beta-lactamase VIM-20 with L-captopril | | Descriptor: | ACETATE ION, L-CAPTOPRIL, Metallo-beta-lactamase VIM-20, ... | | Authors: | Silwal, S.B, Nix, J.C, Page, R.C. | | Deposit date: | 2024-07-28 | | Release date: | 2025-07-09 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Mutation of an active site-adjacent residue in VIM indirectly dictates interactions with and blunts inhibition by D-captopril.
J.Inorg.Biochem., 271, 2025
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