9OER
 
 | | HalA with lysine, Fe(II), chloride, and a peroxyhemiketal intermediate | | Descriptor: | (2S)-2-hydroperoxy-2-hydroxypentanedioic acid, (4R)-4-chloro-L-lysine, 2-OXOGLUTARIC ACID, ... | | Authors: | Kissman, E.N, Yang, A.Y, Chang, M.C.Y. | | Deposit date: | 2025-04-29 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Dynamic metal coordination controls chemoselectivity in a radical halogenase
To Be Published
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9OES
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9OET
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9OEU
 | | HalA with lysine, succinate, chloride, and vanadium(IV)-oxo at pH 7 | | Descriptor: | CHLORIDE ION, LYSINE, Lysine halogenase, ... | | Authors: | Kissman, E.N, Stone, E.A, Chang, M.C.Y. | | Deposit date: | 2025-04-29 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Dynamic metal coordination controls chemoselectivity in a radical halogenase
To Be Published
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9OEV
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9OEW
 | | HalA N224V with lysine, succinate, chloride, and vanadium(IV)-oxo | | Descriptor: | CHLORIDE ION, LYSINE, Lysine halogenase, ... | | Authors: | Kissman, E.N, Stone, E.A, Chang, M.C.Y. | | Deposit date: | 2025-04-29 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Dynamic metal coordination controls chemoselectivity in a radical halogenase
To Be Published
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9OHT
 | | CD1c presenting GD3 ganglioside | | Descriptor: | (2R,3R,4E)-3-hydroxy-2-octadecanamidooctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-L-glycero-beta-L-altro-non-2-ulopyranonosyl-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, (2S)-2,3-dihydroxypropyl heptadecanoate, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | | Authors: | Cao, T.P, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | CD1c presenting GD3 ganglioside
To Be Published
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9OHU
 | | CD1c presenting GM3 ganglioside | | Descriptor: | (2R,3S,4E)-3-hydroxy-2-octadecanamidooctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-L-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, (2S)-2,3-dihydroxypropyl heptadecanoate, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | | Authors: | Cao, T.P, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | CD1c presenting GM3 ganglioside
To Be Published
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9OHV
 | | CD1c presenting dual lipids MPM and GD3 ganglioside | | Descriptor: | (2R,3R,4E)-3-hydroxy-2-octadecanamidooctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-L-glycero-beta-L-altro-non-2-ulopyranonosyl-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, 1-O-[(S)-hydroxy{[(4S,8S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-beta-D-mannopyranose, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | | Authors: | Cao, T.P, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | CD1c presenting dual lipids MPM and GD3 ganglioside
To Be Published
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9OHW
 | | CD1c presenting GM1 ganglioside | | Descriptor: | (2R,3R,4E)-3-hydroxy-2-octadecanamidooctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-L-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-[beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->4)]-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside, 1-O-[(S)-hydroxy{[(4S,8S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-beta-D-mannopyranose, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | | Authors: | Cao, T.P, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | CD1c presenting GM1 ganglioside
To Be Published
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9OHX
 | | CD1c presenting endogenous lipids | | Descriptor: | (2R)-2,3-dihydroxypropyl hexadecanoate, 2-(cyclohexylazaniumyl)ethanesulfonate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Liao, G, Cao, T.P, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | CD1c presenting endogenous lipids
To Be Published
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9OHY
 | | CD1c presenting phosphomycoketide in its open conformation | | Descriptor: | (4S,8S,12R,16S,20S)-4,8,12,16,20-pentamethylheptacosyl dihydrogen phosphate, 2-(cyclohexylazaniumyl)ethanesulfonate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Cao, T.P, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | CD1c presenting phosphomycoketide in its open conformation
To Be Published
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9OHZ
 | | Crystal structure of CD1a presenting ganglioside GD3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, N-{(2S,3R)-1-[(4-O-beta-D-galactopyranosyl-beta-D-glucopyranosyl)oxy]-3-hydroxyoctadecan-2-yl}tetracosanamide, ... | | Authors: | Cao, T.P, Ciacchi, L, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Crystal structure of CD1a presenting ganglioside GD3
To Be Published
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9OI0
 | | Crystal structure of CD1b presenting ganglioside GD3 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | | Authors: | Chen, Y, Cao, T.P, Farquhar, R, Rossjohn, J, Shahine, A. | | Deposit date: | 2025-05-05 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structure of CD1b presenting ganglioside GD3
To Be Published
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9OQ1
 | | Structure of the sweet receptor bound to sucralose in the loose state, extracellular domain | | Descriptor: | 4-chloro-4-deoxy-alpha-D-galactopyranose-(1-2)-1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose, Taste receptor type 1 member 2, Taste receptor type 1 member 3 | | Authors: | Wang, H, Chen, X, Dai, Y, Lee, C.H. | | Deposit date: | 2025-05-20 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structure and activation mechanism of human sweet taste receptor.
Cell Res., 35, 2025
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9OSO
 | | The specificity and structure of DNA crosslinking by a gut bacterial genotoxin | | Descriptor: | DNA-COLIBACTIN, N-({4-[(2R)-2-amino-2-{4-[(2-{(4Z)-2-methyl-4-[(5S)-5-methylpyrrolidin-2-ylidene]-5-oxo-4,5-dihydro-1H-pyrrol-3-yl}acetamido)acetyl]-1,3-thiazol-2-yl}acetyl]-1,3-thiazol-2-yl}methyl)-2-{(4Z)-2-methyl-4-[(5S)-5-methylpyrrolidin-2-ylidene]-5-oxo-4,5-dihydro-1H-pyrrol-3-yl}acetamide | | Authors: | D'Souza, V.D, Balskus, E.P. | | Deposit date: | 2025-05-25 | | Release date: | 2025-11-19 | | Method: | SOLUTION NMR | | Cite: | The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin
Science, 2025
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9OTY
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9OUL
 | | DDB1-CRBN with Ikaros(ZF2), SB-405483, and DEG-47: composite map and model submission | | Descriptor: | DNA damage-binding protein 1, N-[3-(benzyloxy)pyridin-2-yl]-N'-(4-cyano-2-hydroxyphenyl)urea, N-{2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}benzamide, ... | | Authors: | Rizvi, Z, Lander, G.C. | | Deposit date: | 2025-05-28 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Identification of a cryptic allosteric site on the E3 ligase adapter protein cereblon
To Be Published
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9P1I
 | | Atomic structure of vibrio effector fragment VopV bound to Beta-cytoplasmic/gamma1-cytoplasmic F-actin | | Descriptor: | Actin, cytoplasmic 1, MAGNESIUM ION, ... | | Authors: | Kreutzberger, M.A, Kudryashova, E, Egelman, E.H, Kudryashov, D.S. | | Deposit date: | 2025-06-10 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Actin isoform-specific interactions revealed by Vibrio VopV actin-binding repeat
Proc.Natl.Acad.Sci.USA, 2025
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9P3D
 | | cryo-EM structure of Vibrio effector VopV fragment bound to skeletal alpha F-actin | | Descriptor: | Actin, alpha skeletal muscle, MAGNESIUM ION, ... | | Authors: | Kreutzberger, M.A, Kudryashova, E, Egelman, E.H, Kudryashov, D.S. | | Deposit date: | 2025-06-13 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Actin isoform-specific interactions revealed by Vibrio VopV actin-binding repeat
Proc.Natl.Acad.Sci.USA, 2025
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9P92
 | | Cryo-EM structure of the PAC1nR-VIP-Gs complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Piper, S.J, Lu, J, Sexton, P, Wootten, D. | | Deposit date: | 2025-06-24 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.
To Be Published
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9P93
 | | Cryo-EM structure of the PAC1sR-VIP-Gs complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Piper, S.J, Lu, J, Sexton, P, Wootten, D. | | Deposit date: | 2025-06-24 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | TBD Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.
To Be Published
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9P94
 | | Cryo-EM structure of the PAC1sR-PACAP27-Gs complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Piper, S.J, Sexton, P, Wootten, D. | | Deposit date: | 2025-06-24 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | TBD Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.
To Be Published
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9P9U
 | | EGFR-KDD with compound2 | | Descriptor: | 3-(furan-2-yl)-N-[5-(furan-2-yl)-2-methoxyphenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Epidermal growth factor receptor | | Authors: | Long, H, Zaritza, O.P, Mark, A.L. | | Deposit date: | 2025-06-24 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | EGFR-KDD with compound2
To Be Published
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9P9V
 | | Human ClpX initial assembly | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent clpX-like chaperone, mitochondrial | | Authors: | Chen, W.C. | | Deposit date: | 2025-06-24 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Assembly and proteolytic activation human ClpXP defined by cryo-EM
To Be Published
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