9HDA
 
 | | Crystal structure of human TRF1 TRFH domain in complex with compound 58 | | Descriptor: | 1,2-ETHANEDIOL, 4-IODOPYRAZOLE, Telomeric repeat-binding factor 1 | | Authors: | Casale, G, Le Bihan, Y.-V, Van Montfort, R.L.M, Guettler, S. | | Deposit date: | 2024-11-12 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of first-in-class inhibitors of the TRF1-TIN2 protein-protein interaction by fragment screening
To Be Published
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9HDW
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9HJM
 | | Porphyromonas gingivalis BAM complex | | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, DUF4270 domain-containing protein, DUF4827 domain-containing protein, ... | | Authors: | Madej, M, Silale, A, van den Berg, B. | | Deposit date: | 2024-11-29 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Structure of a distinct beta-barrel assembly machinery complex in the Bacteroidota.
Nat Microbiol, 10, 2025
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9HQ5
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9HT6
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9HUB
 | | D11 mAbs bound to alpha-Bungarotoxin at pH 7.5 | | Descriptor: | 1,2-ETHANEDIOL, Alpha-bungarotoxin, heavy chain, ... | | Authors: | Wade, J.W, Bohn, M.F, Laustsen, A.H, Morth, J.P. | | Deposit date: | 2024-12-21 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against alpha-neurotoxins.
Mabs, 17, 2025
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9HUO
 | | A01 mAbs bound to cobratoxin at pH 5.5 | | Descriptor: | Alpha-cobratoxin, CHLORIDE ION, GLYCEROL, ... | | Authors: | Wade, J.W, Bohn, M.F, Laustsen, A.H, Morth, J.P. | | Deposit date: | 2024-12-23 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against alpha-neurotoxins.
Mabs, 17, 2025
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9HUR
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9HV7
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9HVD
 | | Native human P-eIF2-eIF2B complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit delta, ... | | Authors: | De Miguel, C, Thorkelsson, S.R, Wang, C, Bertolotti, A. | | Deposit date: | 2024-12-27 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | PPP1R15B rescues eIF2B from inhibition by P-eIF2 in translation regulation
Science, 2025
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9HVE
 | | Native human eIF2-eIF2B complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | | Authors: | De Miguel, C, Thorkelsson, S.R, Wang, C, Bertolotti, A. | | Deposit date: | 2024-12-27 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure of a native eIF2-eIF2B complex at 2.7 Angstroms resolution.
Science, 2025
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9HVF
 | | Native human PPP1R15B-P-eIF2-eIF2B complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | | Authors: | De Miguel, C, Thorkelsson, S.R, Wang, C, Bertolotti, A. | | Deposit date: | 2024-12-27 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Local refinement of a P-eIF2-eIF2B complex bound to R15B.
Science, 2025
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9HXO
 | | A01 mAbs bound to cobratoxin at pH 6.0 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-cobratoxin, CHLORIDE ION, ... | | Authors: | Wade, J.W, Bohn, M.F, Laustsen, A.H, Morth, J.P. | | Deposit date: | 2025-01-07 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against alpha-neurotoxins.
Mabs, 17, 2025
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9HYD
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9HYE
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9I08
 | | The Paulinella chromatophore transit peptide part2 (crTPpart2) from ArgC | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... | | Authors: | Klimenko, V, Reiners, J, Applegate, V, Reimann, K, Hoeppner, A, Smits, S.H.J, Nowack, E.C.M. | | Deposit date: | 2025-01-14 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Paulinella chromatophore transit peptide part2 adopts a structural fold similar to the gamma-glutamyl-cyclotransferase fold.
Plant Physiol., 199, 2025
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9I09
 | | The Paulinella chromatophore transit peptide part2 (crTPpart2) of RnaH | | Descriptor: | N-PROPANOL, Transit peptide part2 (crTPpart2) | | Authors: | Klimenko, V, Reiners, J, Applegate, V, Reimann, K, Hoeppner, A, Smits, S.H.J, Nowack, E.C.M. | | Deposit date: | 2025-01-14 | | Release date: | 2025-11-19 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | The Paulinella chromatophore transit peptide part2 adopts a structural fold similar to the gamma-glutamyl-cyclotransferase fold.
Plant Physiol., 199, 2025
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9IBI
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9IBK
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9IQQ
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9IXA
 | | Cryo-EM structure of chikungunya virus glycoprotein E1-E2 with C34 Fab. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C34 Fab, Heavy Chain, ... | | Authors: | Han, X, Ji, C, Wang, F, Tian, S, Gao, F.G, Yan, J. | | Deposit date: | 2024-07-26 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action.
Nat Commun, 16, 2025
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9IXI
 | | VLP structure of Chikungunya virus, 2f block. | | Descriptor: | CHIKV E1, CHIKV E2, CHIKV capsid protein | | Authors: | Han, X, Ji, C, Wang, F, Tian, S, Gao, F.G, Yan, J. | | Deposit date: | 2024-07-28 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action.
Nat Commun, 16, 2025
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9J6H
 | | Complex I from respirasome closed state 1 bound by metformin and CoQ10 (SC-MetC1-iv) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-08-16 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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9J6W
 | | Complex I from respirasome closed state 1 bound by metformin and CoQ10 (SC-MetC1-v) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-08-17 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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9J74
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