9T32
 
 | | The Cullin 2 RING VHL E3 ligase dimerised by the homoPROTAC CM11 | | Descriptor: | (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[2-[2-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-2-oxidanylidene-ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Crowe, C, Ciulli, A. | | Deposit date: | 2025-10-24 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (6.9 Å) | | Cite: | Linker-rigidified VHL homodimerizers convert degraders into stabilizers of non-ubiquitinable ternary complexes
Biorxiv, 2025
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9T3P
 | | Nonameric Ena1C ring of Bacillus cereus | | Descriptor: | DUF3992 domain-containing protein | | Authors: | Sleutel, M, Remaut, H. | | Deposit date: | 2025-10-28 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Spatiotemporal Expression of Endospore Appendages and Cryo-EM Insights
into Ena1C-Mediated S-ENA Anchoring in Bacillus paranthracis
To Be Published
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9V6J
 | | Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity | | Descriptor: | (E)-1-(4-chlorobenzyl)-3-fluoro-1-(3-hydroxypropyl)-1,1,1,1-tetrahydro-1H-2,4-dioxa-1(8,3)-purina-3(1,3)-benzenacyclodecaphane-1,1-dione, CALCIUM ION, Short transient receptor potential channel 5, ... | | Authors: | Che, T, Zhang, J, Xiong, B, Cheng, X.Y. | | Deposit date: | 2025-05-27 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity
To Be Published
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9VH1
 | | cryoEM structure of ptuA-ptuB complex in Retron-Eco7 anti-phage system | | Descriptor: | Retron Ec78 probable ATPase, Retron Ec78 putative HNH endonuclease, ZINC ION | | Authors: | Dai, Z.K, Wang, Y.J, Guan, Z.Y, Zou, T.T. | | Deposit date: | 2025-06-16 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Phage nuclease-mediated defense activation of the bacterial Retron-Eco7 toxin-antitoxin system.
Nucleic Acids Res., 53, 2025
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9VI9
 | | Cryo-EM Structure of NPFFR1 in complex with peptide RFRP-3 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Na, M, Xu, F. | | Deposit date: | 2025-06-17 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Molecular Recognition at the Opioid-modulating Neuropeptide FF Receptor 1.
Protein Cell, 2025
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9VIF
 | | Cryo-EM Structure of NPFFR1 in complex with peptide NPFF | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Na, M, Xu, F. | | Deposit date: | 2025-06-18 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Molecular Recognition at the Opioid-modulating Neuropeptide FF Receptor 1.
Protein Cell, 2025
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9VOG
 | | Vitamin D receptor complex with a 5-{4-(m-carboran-1-yl)phenoxy}-4-hydroxypentanoic acid derivative | | Descriptor: | (S)-5-[4-{7-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1,7-dicarba-closo-dodecaboran-1-yl}phenoxy]-4-hydroxypentanoic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | | Authors: | Mudiyanselage, H.N.T.N, Hanazono, Y, Ito, N, Kagechika, H, Fujii, S. | | Deposit date: | 2025-07-01 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold.
Eur.J.Med.Chem., 302, 2025
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9VOH
 | | Vitamin D receptor complex with a 4-(m-carboran-1-yl)phenoxyacetic acid derivative | | Descriptor: | Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor, [4-{7-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1,7-dicarba- closo-dodecaboran-1-yl}phenoxy]acetic acid | | Authors: | Mudiyanselage, H.N.T.N, Hanazono, Y, Ito, N, Kagechika, H, Fujii, S. | | Deposit date: | 2025-07-01 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold.
Eur.J.Med.Chem., 302, 2025
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9VOI
 | | Vitamin D receptor complex with a 3-{4-(m-carboran-1-yl)phenoxy}propanoic acid derivative | | Descriptor: | 3-[4-{7-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1,7-dicarba-closo-dodecaboran-1-yl}phenoxy]propionic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | | Authors: | Mudiyanselage, H.N.T.N, Hanazono, Y, Ito, N, Kagechika, H, Fujii, S. | | Deposit date: | 2025-07-01 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold.
Eur.J.Med.Chem., 302, 2025
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9VOJ
 | | Vitamin D receptor complex with a 4-{4-(m-carboran-1-yl)phenoxy}butanoic acid derivative | | Descriptor: | 4-[4-{7-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1,7-dicarba-closo-dodecaboran-1-yl}phenoxy]butyric acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | | Authors: | Mudiyanselage, H.N.T.N, Hanazono, Y, Ito, N, Kagechika, H, Fujii, S. | | Deposit date: | 2025-07-01 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold.
Eur.J.Med.Chem., 302, 2025
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9VOK
 | | Vitamin D receptor complex with a 5-{4-(m-carboran-1-yl)phenoxy}pentanoic acid derivative | | Descriptor: | 5-[4-{7-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1,7-dicarba-closo-dodecaboran-1-yl}phenoxy]pentanoic acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | | Authors: | Mudiyanselage, H.N.T.N, Hanazono, Y, Ito, N, Kagechika, H, Fujii, S. | | Deposit date: | 2025-07-01 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold.
Eur.J.Med.Chem., 302, 2025
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9VOL
 | | Vitamin D receptor complex with a 4-{4-(m-carboran-1-yl)-2-methylphenoxy}butanoic acid derivative | | Descriptor: | 4-[4-{7-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1,7-dicarba-closo-dodecaboran-1-yl}-2-methylphenoxy]butyric acid, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | | Authors: | Mudiyanselage, H.N.T.N, Hanazono, Y, Ito, N, Kagechika, H, Fujii, S. | | Deposit date: | 2025-07-01 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Design, synthesis and structural development of nonsecosteroidal VDR ligands based on the C,C'-diphenyl-m-carborane scaffold.
Eur.J.Med.Chem., 302, 2025
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9W4R
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9W4S
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9WNO
 | | Cryo-EM structure of Candida glabrata GPI mannosyltransferase I bound to Dol-P-Man | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Sun, H, Wu, W.H, Yan, Z.F. | | Deposit date: | 2025-09-05 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Structural Insights into the Glycosylphosphatidylinositol Mannosyltransferase I Complex from Candida glabrata
J Fungi, 11, 2025
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9X2O
 | | X-ray structure of antiviral protein from Mirabilis jalapa | | Descriptor: | Antiviral protein MAP, SULFATE ION | | Authors: | Nishida, N, Ninomiya, Y, Yoshida, T, Habuka, N, Tsuge, H. | | Deposit date: | 2025-10-07 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of Ribosome-inactivating protein from Mirabilis jalapa and stalk-dependent inhibition of E.coli ribosome
To Be Published
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9XGO
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9Y9W
 | | Vibrio cholerae protein FrhA peptid-binding domain and adjacent split domain (S1127-F1439) in complex with peptide AGWTD X-ray crystallography structure | | Descriptor: | 1,2-ETHANEDIOL, Ala-Gly-Trp-Thr-Asp (AGWTD), CALCIUM ION, ... | | Authors: | Wang, M, Guo, S, Kinrade, B, Davies, P. | | Deposit date: | 2025-09-15 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Peptide-based ligand antagonists block a Vibrio cholerae adhesin.
Febs Lett., 2025
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9Y9Z
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9YA1
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9YA2
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9YA3
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9YBQ
 | | Vibrio cholerae protein FrhA peptid-binding domain and adjacent split domain (S1127-F1439) in complex with peptide AGYTD X-ray crystallography structure | | Descriptor: | ALA-GLY-TYR-THR-ASP, CALCIUM ION, Cadherin domain protein | | Authors: | Wang, M, Guo, S, Kinrade, B, Davies, P. | | Deposit date: | 2025-09-17 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Peptide-based ligand antagonists block a Vibrio cholerae adhesin.
Febs Lett., 2025
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9YK4
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9YNU
 | | Tra1 and core modules including core tip of ctSAGA complex | | Descriptor: | Non-specific serine/threonine protein kinase, Putative transcription initiation factor, Putative transcriptional coactivator HFI1 protein, ... | | Authors: | Mattoo, R.U.H, Chen, D.H, Bushnell, D.A, Tamir, S, Kornberg, R.D. | | Deposit date: | 2025-10-12 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module.
Mol.Cell, 2025
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