COVID-19特輯

冠狀病毒，2020. 由David S. Goodsell @ RCSB PDB原圖修改

最近爆發的新型冠狀病毒傳染病（Novel Coronavirus disease 2019: COVID-19）對全世界的人們都構成了嚴重威脅。為了儘早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以開發出有效的抗病毒藥物，已經有很多科研人員開始了相關蛋白結構的研究，並且將所獲得結構數據存儲與PDB。 PDBj為用戶提供了COVID-19相關數據一覽的門戶頁面，並將於每週三更新當日新發佈的相關數據。

有關該病毒蛋白質的解說，請參見下面的“當月的分子”頁面。

“所有結構”標籤的頁面則逐一羅列了所有的數據，包括由同一研究組提交的系列數據群。 “代表性結構”標籤的頁面精選具有相同胺基酸序列的結構數據中的高分辨率數據，不重複選擇具有同一胺基酸序列的數據，即使該數據可能包含不同的配體。 “最新條目”標籤內包含本週新更新數據。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有結構 (5197)代表性結構 (2266)最新條目 (44)

9F7A

SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P80R
Descriptor:	Nucleoprotein, ZINC ION
Authors:	Dhamotharan, K, Schlundt, A.
Deposit date:	2024-05-03
Release date:	2024-11-20
Last modified:	2024-12-18
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding. Nat Commun, 15, 2024

9F7C

SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant S105I
Descriptor:	Nucleoprotein, ZINC ION
Authors:	Dhamotharan, K, Schlundt, A.
Deposit date:	2024-05-03
Release date:	2024-11-20
Last modified:	2024-12-18
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding. Nat Commun, 15, 2024

9F83

SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant D63G
Descriptor:	Nucleoprotein
Authors:	Dhamotharan, K, Schlundt, A, Guenther, S.
Deposit date:	2024-05-06
Release date:	2024-11-20
Last modified:	2024-12-18
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding. Nat Commun, 15, 2024

9FBG

SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S
Descriptor:	Nucleoprotein
Authors:	Dhamotharan, K, Schlundt, A.
Deposit date:	2024-05-13
Release date:	2024-11-20
Last modified:	2024-12-18
Method:	X-RAY DIFFRACTION (2.54 Å)
Cite:	A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding. Nat Commun, 15, 2024

9GWO

SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and theophylline derivative LAS 54571126
Descriptor:	1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:	Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A.
Deposit date:	2024-09-27
Release date:	2024-11-20
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders To Be Published

8RJ7

The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Camel-derived nanobody 1.29, LYSINE, ...
Authors:	Casasnovas, J.M, Fernandez, L.A, Silva, K.
Deposit date:	2023-12-20
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29 To Be Published

8YKJ

Crystal structure of SARS-Cov-2 main protease in complex with X77
Descriptor:	N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide, Non-structural protein 11
Authors:	Zhou, X.L, Lin, C, Li, W.W, Zhang, J, Li, J.
Deposit date:	2024-03-05
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.99 Å)
Cite:	Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77. Int.J.Biol.Macromol., 276, 2024

8YKM

Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with X77
Descriptor:	3C-like proteinase nsp5, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide
Authors:	Zeng, P, Zhang, J, Li, J.
Deposit date:	2024-03-05
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.84 Å)
Cite:	Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77. Int.J.Biol.Macromol., 276, 2024

8YKN

Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with X77
Descriptor:	N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide, Non-structural protein 11
Authors:	Wang, J, Zhang, J, Li, J.
Deposit date:	2024-03-05
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.77 Å)
Cite:	Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77. Int.J.Biol.Macromol., 276, 2024

8YKO

Crystal structure of SARS-Cov-2 main protease P132H mutant in complex withX77
Descriptor:	3C-like proteinase nsp5, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide
Authors:	Li, W.W, Zhang, J, Li, J.
Deposit date:	2024-03-05
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (2.11 Å)
Cite:	Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77. Int.J.Biol.Macromol., 276, 2024

8YKP

Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with X77
Descriptor:	3C-like proteinase nsp5, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide
Authors:	Zou, X.F, Zhang, J, Li, J.
Deposit date:	2024-03-05
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77. Int.J.Biol.Macromol., 276, 2024

8YKQ

Crystal structure of SARS-Cov-2 main protease V186F mutant in complex with X77
Descriptor:	3C-like proteinase nsp5, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide
Authors:	Zou, X.F, Zhang, J, Li, J.
Deposit date:	2024-03-05
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77. Int.J.Biol.Macromol., 276, 2024

9CRC

Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: B.1 variant 3 closed RBDs
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ke, Z, Croll, T.I, Briggs, J.A.G.
Deposit date:	2024-07-22
Release date:	2024-11-27
Last modified:	2024-12-25
Method:	ELECTRON MICROSCOPY (2.9 Å)
Cite:	Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Embo J., 43, 2024

9CRD

Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: B.1 variant 1 open RBD
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ke, Z, Croll, T.I, Briggs, J.A.G.
Deposit date:	2024-07-22
Release date:	2024-11-27
Last modified:	2024-12-25
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Embo J., 43, 2024

9CRE

Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Alpha (B.1.1.7) variant 3 closed RBDs
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ke, Z, Croll, T.I, Briggs, J.A.G.
Deposit date:	2024-07-22
Release date:	2024-11-27
Last modified:	2024-12-25
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Embo J., 43, 2024

9CRF

Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Alpha (B.1.1.7) variant 1 open RBD
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ke, Z, Croll, T.I, Briggs, J.A.G.
Deposit date:	2024-07-22
Release date:	2024-11-27
Last modified:	2024-12-25
Method:	ELECTRON MICROSCOPY (4 Å)
Cite:	Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Embo J., 43, 2024

9CRG

Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Gamma (P.1) variant 3 closed RBDs
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ke, Z, Kotecha, A, Briggs, J.A.G.
Deposit date:	2024-07-22
Release date:	2024-11-27
Last modified:	2024-12-25
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Embo J., 43, 2024

9CRH

Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Delta (B.1.617.2) variant 3 closed RBDs
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ke, Z, Briggs, J.A.G.
Deposit date:	2024-07-22
Release date:	2024-11-27
Last modified:	2024-12-25
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Embo J., 43, 2024

9CRI

Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Mu (B.1.621) variant 3 closed RBDs
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Ke, Z, Briggs, J.A.G.
Deposit date:	2024-07-22
Release date:	2024-11-27
Last modified:	2024-12-25
Method:	ELECTRON MICROSCOPY (2.8 Å)
Cite:	Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants. Embo J., 43, 2024

9HBQ

SARS-CoV-2 Main Protease complexed with (1R)-N-(3-chlorophenyl)-3-oxo-indane-1-carboxamide
Descriptor:	(1~{R})-~{N}-(3-chlorophenyl)-3-oxidanylidene-1,2-dihydroindene-1-carboxamide, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
Authors:	Hanoulle, X, Charton, J, Deprez, B.
Deposit date:	2024-11-08
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.795 Å)
Cite:	SARS-CoV-2 Main Protease complexed with (1R)-N-(3-chlorophenyl)-3-oxo-indane-1-carboxamide To Be Published

9HC1

SARS-CoV-2 Main Protease complexed with (1R)-N-(3-chlorophenyl)-3-oxo-N-[4-(2-oxopyrrolidin-1-yl)phenyl]indane-1-carboxamide
Descriptor:	(1~{R})-~{N}-(3-chlorophenyl)-3-oxidanylidene-~{N}-[4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]-1,2-dihydroindene-1-carboxamide, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
Authors:	Hanoulle, X, Charton, J, Deprez, B.
Deposit date:	2024-11-08
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.493 Å)
Cite:	SARS-CoV-2 Main Protease complexed with (1R)-N-(3-chlorophenyl)-3-oxo-N-[4-(2-oxopyrrolidin-1-yl)phenyl]indane-1-carboxamide To Be Published

9HD8

SARS-CoV-2 Main Protease in complex with with (1R)-N-(3-chlorophenyl)-N-[4-(2,4-dioxo-1H-pyrimidin-5-yl)phenyl]-3-oxo-indane-1-carboxamide
Descriptor:	(1~{R})-~{N}-[4-[2,4-bis(oxidanylidene)-1~{H}-pyrimidin-5-yl]phenyl]-~{N}-(3-chlorophenyl)-3-oxidanylidene-1,2-dihydroindene-1-carboxamide, 3C-like proteinase nsp5, SODIUM ION
Authors:	Hanoulle, X, Charton, J, Deprez, B.
Deposit date:	2024-11-12
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.696 Å)
Cite:	SARS-CoV-2 Main Protease in complex with with (1R)-N-(3-chlorophenyl)-N-[4-(2,4-dioxo-1H-pyrimidin-5-yl)phenyl]-3-oxo-indane-1-carboxamide To Be Published

9HDC

SARS-CoV-2 Main Protease in complex with (3S)-3-[(3R)-3-phenylpiperidine-1-carbonyl]indan-1-one
Descriptor:	(3~{S})-3-[(3~{R})-3-phenylpiperidin-1-yl]carbonyl-2,3-dihydroinden-1-one, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
Authors:	Hanoulle, X, Charton, J, Deprez, B.
Deposit date:	2024-11-12
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.794 Å)
Cite:	SARS-CoV-2 Main Protease in complex with (3S)-3-[(3R)-3-phenylpiperidine-1-carbonyl]indan-1-one To Be Published

9HDJ

SARS-CoV-2 Main Protease in complex with (3R)-3-[(3R)-4-benzyl-3-phenyl-piperidine-1-carbonyl]indan-1-one
Descriptor:	(3~{R})-3-[(3~{R})-3-phenyl-4-(phenylmethyl)piperazin-1-yl]carbonyl-2,3-dihydroinden-1-one, 3C-like proteinase nsp5, FORMIC ACID
Authors:	Hanoulle, X, Charton, J, Deprez, B.
Deposit date:	2024-11-12
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	SARS-CoV-2 Main Protease in complex with (3R)-3-[(3R)-4-benzyl-3-phenyl-piperidine-1-carbonyl]indan-1-one To Be Published

9HDN

SARS-CoV-2 Main Protease in complex with (1R)-3-oxo-N-[2-oxo-2-(N-phenylanilino)ethyl]indane-1-carboxamide
Descriptor:	(1~{R})-~{N}-[2-(diphenylamino)-2-oxidanylidene-ethyl]-3-oxidanylidene-1,2-dihydroindene-1-carboxamide, 3C-like proteinase nsp5
Authors:	Hanoulle, X, Charton, J, Deprez, B.
Deposit date:	2024-11-12
Release date:	2024-11-27
Method:	X-RAY DIFFRACTION (1.77 Å)
Cite:	SARS-CoV-2 Main Protease in complex with (1R)-3-oxo-N-[2-oxo-2-(N-phenylanilino)ethyl]indane-1-carboxamide To Be Published

<178 179 180 181 182 183 184185186 187 188 189 190 191 192 193 >

Total results:	5197
Displayed results:	25
Sorted by:	Release date (from oldest)