COVID-19特輯

冠狀病毒，2020. 由David S. Goodsell @ RCSB PDB原圖修改

最近爆發的新型冠狀病毒傳染病（Novel Coronavirus disease 2019: COVID-19）對全世界的人們都構成了嚴重威脅。為了儘早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以開發出有效的抗病毒藥物，已經有很多科研人員開始了相關蛋白結構的研究，並且將所獲得結構數據存儲與PDB。 PDBj為用戶提供了COVID-19相關數據一覽的門戶頁面，並將於每週三更新當日新發佈的相關數據。

有關該病毒蛋白質的解說，請參見下面的“當月的分子”頁面。

“所有結構”標籤的頁面則逐一羅列了所有的數據，包括由同一研究組提交的系列數據群。 “代表性結構”標籤的頁面精選具有相同胺基酸序列的結構數據中的高分辨率數據，不重複選擇具有同一胺基酸序列的數據，即使該數據可能包含不同的配體。 “最新條目”標籤內包含本週新更新數據。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有結構 (4406)代表性結構 (1944)最新條目 (19)

8YB7

SARS-CoV-2 DMV nsp3-4 pore complex (consensus-pore, C3 symmetry)
Descriptor:	Non-structural protein 4, Papain-like protease nsp3
Authors:	Huang, Y.X, Zhong, L.J, Zhang, W.X, Ni, T.
Deposit date:	2024-02-12
Release date:	2024-06-19
Method:	ELECTRON MICROSCOPY (4.6 Å)
Cite:	Molecular Architecture of Coronavirus Double Membrane Vesicle Pore Complex To Be Published

9EOW

The 5-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH
Descriptor:	RNA (29-MER)
Authors:	Wacker, A, Schwalbe, H.
Deposit date:	2024-03-15
Release date:	2024-06-19
Method:	SOLUTION NMR
Cite:	The 5'-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH. Nucleic Acids Res., 2024

8T7Y

Structure of SARS CoV-2 main protease in complex with Chymostatin.
Descriptor:	3C-like proteinase nsp5, Chymostatin A (bound form)
Authors:	Terzyan, S, Yarla, N, Rao, C.V, Mooers, B.
Deposit date:	2023-06-21
Release date:	2024-06-26
Method:	X-RAY DIFFRACTION (1.78 Å)
Cite:	Structure of SARS CoV-2 main protease in complex with Chymostatin. to be published

8WHZ

BA.2.86 RBD in complex with hACE2 (local refinement)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Processed angiotensin-converting enzyme 2, ...
Authors:	Yue, C, Liu, P.
Deposit date:	2023-09-23
Release date:	2024-06-26
Method:	ELECTRON MICROSCOPY (3.93 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8X4Z

BA.2.86 Spike Trimer with ins483V mutation (3 RBD down)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Yue, C, Liu, P.
Deposit date:	2023-11-16
Release date:	2024-06-26
Method:	ELECTRON MICROSCOPY (3.49 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8X50

BA.2.86 Spike Trimer with ins483V mutation (1 RBD up)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Yue, C, Liu, P.
Deposit date:	2023-11-16
Release date:	2024-06-26
Method:	ELECTRON MICROSCOPY (3.82 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8X55

BA.2.86 Spike Trimer with T356K mutation (3 RBD down)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Yue, C, Liu, P.
Deposit date:	2023-11-16
Release date:	2024-06-26
Method:	ELECTRON MICROSCOPY (3.75 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8X56

BA.2.86 Spike Trimer with T356K mutation (1 RBD up)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Yue, C, Liu, P.
Deposit date:	2023-11-16
Release date:	2024-06-26
Method:	ELECTRON MICROSCOPY (3.93 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8JUX

Crystal structure of SARS-CoV-2 Papain-like protease complexed with noncovalent inhibitor SR-01
Descriptor:	MAGNESIUM ION, Non-structural protein 7, ~{N}-[(3-fluorophenyl)methyl]-1-[(1~{R})-1-(3-methoxynaphthalen-1-yl)ethyl]piperidine-4-carboxamide
Authors:	Hsieh, Y.-J, Wu, K.-P.
Deposit date:	2023-06-27
Release date:	2024-07-03
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Crystal structure of SARS-CoV-2 Papain-like protease complexed with noncovalent inhibitor SR-01 To Be Published

8OYT

Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ...
Authors:	Weckener, M, Naismith, J.H, Owens, R.J.
Deposit date:	2023-05-05
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2. Open Biology, 14, 2024

8WHS

Spike Trimer of BA.2.86 in complex with one hACE2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Processed angiotensin-converting enzyme 2, ...
Authors:	Yue, C, Liu, P.
Deposit date:	2023-09-23
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.33 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8WHU

Spike Trimer of BA.2.86 in complex with two hACE2s
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Processed angiotensin-converting enzyme 2, ...
Authors:	Yue, C, Liu, P.
Deposit date:	2023-09-23
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8WHV

Spike Trimer of BA.2.86 with three RBDs down
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Yue, C, Liu, P.
Deposit date:	2023-09-23
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.32 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8WHW

Spike Trimer of BA.2.86 with single RBD up
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Yue, C, Liu, P.
Deposit date:	2023-09-23
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.85 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8WP8

Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:	Li, L.J, Gu, Y.H, Qi, J.X, Gao, G.F.
Deposit date:	2023-10-09
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (2.89 Å)
Cite:	Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2 To Be Published

8X4H

SARS-CoV-2 JN.1 Spike
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Yue, C, Liu, P.
Deposit date:	2023-11-15
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.65 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8X5Q

SARS-CoV-2 BA.2.75 Spike with K356T mutation (3 RBD down)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Yue, C, Liu, P.
Deposit date:	2023-11-17
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.47 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8X5R

SARS-CoV-2 BA.2.75 Spike with K356T mutation (1 RBD up)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Yue, C, Liu, P.
Deposit date:	2023-11-17
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.72 Å)
Cite:	Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity Natl Sci Rev, 2024

8XLV

Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 spike protein(6P), 1-RBD-up state
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
Deposit date:	2023-12-26
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.07 Å)
Cite:	Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published

8XM5

Cryo-EM structure of SARS-CoV-2 Omicron EG.5 spike protein(6P), RBD-closed state
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
Deposit date:	2023-12-27
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (2.61 Å)
Cite:	Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published

8XMG

Cryo-EM structure of SARS-CoV-2 Omicron HV.1 spike protein(6P), RBD-closed state
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
Deposit date:	2023-12-27
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (2.9 Å)
Cite:	Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published

8XMT

Cryo-EM structure of SARS-CoV-2 Omicron EG.5.1 spike protein(6P), RBD-closed state
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
Deposit date:	2023-12-28
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (3.31 Å)
Cite:	Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published

8XN2

SARS-CoV-2 Omicron EG.5.1 RBD in complex with human ACE2 (local refined from the spike protein)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
Authors:	Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
Deposit date:	2023-12-28
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (2.79 Å)
Cite:	Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published

8XN3

SARS-CoV-2 Omicron HV.1 RBD in complex with human ACE2 (local refinement from the spike protein)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
Authors:	Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
Deposit date:	2023-12-28
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (2.64 Å)
Cite:	Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published

8XN5

Cryo-EM structure of SARS-CoV-2 Omicron EG.5.1 spike protein(6P) in complex with human ACE2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ...
Authors:	Li, L.J, Gu, Y.H, Shi, K.Y, Qi, J.X, Gao, G.F.
Deposit date:	2023-12-29
Release date:	2024-07-03
Method:	ELECTRON MICROSCOPY (2.87 Å)
Cite:	Structural basis of receptor binding and immune escape for SARS-CoV-2 Omicron BA.2.86, EG.5, EG.5.1 and HV.1 sub-variants To Be Published

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