COVID-19特辑

冠状病毒，2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病（Novel Coronavirus disease 2019: COVID-19）对全世界的人们都构成了严重威胁。为了尽早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以开发出有效的抗病毒药物，已经有很多科研人員开始了相关蛋白结构的研究，并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面，并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说，请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据，包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据，不重复选择具同一氨基酸序列的数据，即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有结构 (5197)代表性结构 (2266)最新条目 (44)

9MPW

SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab M15 Heavy Chain, ...
Authors:	Sapse, I.A, Bajic, G.
Deposit date:	2024-12-31
Release date:	2025-07-09
Method:	ELECTRON MICROSCOPY (3.37 Å)
Cite:	SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment To Be Published

9RCZ

Structure of the N-terminal domain of non-structural protein 1 (Nsp1) from SARS-CoV-2
Descriptor:	ORF1a polyprotein
Authors:	Lennartz, F, Weiss, M.S.
Deposit date:	2025-05-30
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Crystallographic fragment screening against SARS-CoV-2 Nsp1 using the F2X-Entry Screen and a newly developed fragment library. To Be Published

9RHS

Structure of 3CL protease with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, ~{N}-(4-bromanyl-3-nitro-phenyl)-2-(1,2,3-triazol-1-yl)ethanamide
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-10
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.638 Å)
Cite:	SARS-CoV-2 3CL protease with a bound inhibitor To Be Published

9RHT

Structure of 3CL protease with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, DIMETHYL SULFOXIDE, SODIUM ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-10
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.624 Å)
Cite:	SARS-CoV-2 3CL protease with a bound inhibitor To Be Published

9RHX

SARS-CoV-2 main protease with a bound inhibitor
Descriptor:	2-pyridin-3-ylquinazoline, 3C-like proteinase nsp5, CHLORIDE ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-10
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.62 Å)
Cite:	SARS-CoV-2 main protease with a bound inhibitor To Be Published

9RI0

SARS-CoV-2 3CL protease with a bound inhibitor
Descriptor:	1,2-ETHANEDIOL, 3C-like proteinase nsp5, CHLORIDE ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-10
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.39 Å)
Cite:	SARS-CoV-2 3CL protease with a bound inhibitor To Be Published

9RI1

SARS-CoV-2 with a bound inhibitor
Descriptor:	(4~{R})-~{N}-(3,4-dipropoxyphenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase nsp5, BROMIDE ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-10
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.309 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RI3

SARS-CoV-2 with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, DIMETHYL SULFOXIDE, SODIUM ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-11
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.723 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RI4

SARS-CoV-2 with a bound inhibitor
Descriptor:	2-azanyl-~{N}-[(1~{R},2~{S})-2-(4-chloranyl-3-fluoranyl-phenyl)cyclopropyl]-6-nitro-benzamide, 3C-like proteinase nsp5, SODIUM ION
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-11
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.762 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RI5

SARS-CoV-2 with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, SULFATE ION, ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-2-pyridin-3-yl-~{N}-(thiophen-2-ylmethyl)ethanamide
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-11
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.634 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RI8

SARS-CoV-2 with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, 4-(azetidin-1-yl)-2-isoquinolin-4-yl-thieno[2,3-d]pyrimidine, DIMETHYL SULFOXIDE, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-11
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.781 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RID

SARS-CoV-2 with a bound inhibitor
Descriptor:	(2~{R})-2-[2-(benzotriazol-1-yl)ethanoyl-methyl-amino]-2-(3-fluorophenyl)ethanamide, 3C-like proteinase nsp5, SODIUM ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-11
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.63 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RIX

SARS-CoV-2 with a bound inhibitor
Descriptor:	(4~{R})-~{N}-[2-(1-benzothiophen-3-yl)ethyl]-7-fluoranyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.73 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RIY

SARS-CoV-2 with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, DIMETHYL SULFOXIDE, SODIUM ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.788 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RIZ

SARS-CoV-2 with a bound inhibitor
Descriptor:	(4~{R})-~{N}-(3-cyclopropylphenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-1,8-naphthyridine-4-carboxamide, 3C-like proteinase nsp5
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.734 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RJ0

SARS-CoV-2 with a bound inhibitor
Descriptor:	1-(benzimidazol-1-yl)-3-[(4~{S})-6-fluoranyl-3,4-dihydro-2~{H}-thiochromen-4-yl]urea, 3C-like proteinase nsp5, SODIUM ION
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.709 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RJ3

SARS-CoV-2 with a bound inhibitor
Descriptor:	(2~{R})-1-[3-(aminomethyl)-1,2,4-triazol-1-yl]-3-[2,5-bis(chloranyl)phenoxy]propan-2-ol, 3C-like proteinase nsp5, CHLORIDE ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.618 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RJ5

SARS-CoV-2 with a bound inhibitor
Descriptor:	1-(2-cyclohexylethyl)-3-cyclopropyl-1-[(5-methyl-1,2-oxazol-3-yl)methyl]urea, 3C-like proteinase nsp5
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RJ7

SARS-CoV-2 with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, 4-fluoranyl-~{N}-(pyridin-3-ylmethyl)-2,3-dihydroindole-1-carboxamide, SODIUM ION
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.897 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RJ8

SARS-CoV-2 with a bound inhibitor
Descriptor:	3C-like proteinase nsp5, 4-fluoranyl-~{N}-(3-phenoxypropyl)-~{N}-(1,2-thiazol-5-ylmethyl)-2,3-dihydroindole-1-carboxamide
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.433 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RJF

SARS-CoV-2 with a bound inhibitor
Descriptor:	3-(5-bromanylpyridin-3-yl)-1-[(1~{R})-1-phenylethyl]imidazolidine-2,4-dione, 3C-like proteinase nsp5
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.893 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

9RJR

SARS-CoV-2 with a bound inhibitor
Descriptor:	1-[[3,4-bis(fluoranyl)phenyl]methyl]-3-(5-bromanylpyridin-3-yl)imidazolidine-2,4-dione, 3C-like proteinase nsp5, SODIUM ION, ...
Authors:	Mac Sweeney, A.
Deposit date:	2025-06-12
Release date:	2025-07-09
Method:	X-RAY DIFFRACTION (1.705 Å)
Cite:	SARS-CoV-2 with a bound inhibitor To Be Published

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