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신종 코로나바이러스 특집 콘텐츠

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코로나 바이러스
코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.


Created: 2020-09-03 (last edited: more than 1 year ago)2022-09-02
9EWH
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BU of 9ewh by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Y109A
Descriptor: Nucleoprotein
Authors:Dhamotharan, K, Schlundt, A, Guenther, S.
Deposit date:2024-04-03
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9EXB
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BU of 9exb by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain NTD
Descriptor: Nucleoprotein
Authors:Dhamotharan, K, Schlundt, A, Guenther, S.
Deposit date:2024-04-06
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9EZB
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BU of 9ezb by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P67S
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein
Authors:Dhamotharan, K, Schlundt, A, Guenther, S.
Deposit date:2024-04-11
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9F5J
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BU of 9f5j by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant Q58I
Descriptor: CADMIUM ION, Nucleoprotein
Authors:Dhamotharan, K, Schlundt, A.
Deposit date:2024-04-29
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9F5L
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BU of 9f5l by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant A119S
Descriptor: Nucleoprotein
Authors:Dhamotharan, K, Schlundt, A.
Deposit date:2024-04-29
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2.363 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9F7A
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BU of 9f7a by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P80R
Descriptor: Nucleoprotein, ZINC ION
Authors:Dhamotharan, K, Schlundt, A.
Deposit date:2024-05-03
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9F7C
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BU of 9f7c by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant S105I
Descriptor: Nucleoprotein, ZINC ION
Authors:Dhamotharan, K, Schlundt, A.
Deposit date:2024-05-03
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9F83
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BU of 9f83 by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant D63G
Descriptor: Nucleoprotein
Authors:Dhamotharan, K, Schlundt, A, Guenther, S.
Deposit date:2024-05-06
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
9FBG
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BU of 9fbg by Molmil
SARS-CoV-2 Nucleocapsid N-terminal domain (NTD) mutant P151S
Descriptor: Nucleoprotein
Authors:Dhamotharan, K, Schlundt, A.
Deposit date:2024-05-13
Release date:2024-11-20
Last modified:2024-12-18
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding.
Nat Commun, 15, 2024
8RJ7
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BU of 8rj7 by Molmil
The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Camel-derived nanobody 1.29, LYSINE, ...
Authors:Casasnovas, J.M, Fernandez, L.A, Silva, K.
Deposit date:2023-12-20
Release date:2024-11-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29
To Be Published
8YKN
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BU of 8ykn by Molmil
Crystal structure of SARS-Cov-2 main protease K90R mutant in complex with X77
Descriptor: N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide, Non-structural protein 11
Authors:Wang, J, Zhang, J, Li, J.
Deposit date:2024-03-05
Release date:2024-11-27
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.
Int.J.Biol.Macromol., 276, 2024
8YKP
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BU of 8ykp by Molmil
Crystal structure of SARS-Cov-2 main protease M49I mutant in complex with X77
Descriptor: 3C-like proteinase nsp5, N-(4-tert-butylphenyl)-N-[(1R)-2-(cyclohexylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-1H-imidazole-4-carboxamide
Authors:Zou, X.F, Zhang, J, Li, J.
Deposit date:2024-03-05
Release date:2024-11-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of coronaviral main proteases in complex with the non-covalent inhibitor X77.
Int.J.Biol.Macromol., 276, 2024
9CRC
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BU of 9crc by Molmil
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: B.1 variant 3 closed RBDs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ke, Z, Croll, T.I, Briggs, J.A.G.
Deposit date:2024-07-22
Release date:2024-11-27
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
Embo J., 43, 2024
9CRE
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BU of 9cre by Molmil
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Alpha (B.1.1.7) variant 3 closed RBDs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ke, Z, Croll, T.I, Briggs, J.A.G.
Deposit date:2024-07-22
Release date:2024-11-27
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
Embo J., 43, 2024
9CRG
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BU of 9crg by Molmil
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Gamma (P.1) variant 3 closed RBDs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ke, Z, Kotecha, A, Briggs, J.A.G.
Deposit date:2024-07-22
Release date:2024-11-27
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
Embo J., 43, 2024
9CRH
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BU of 9crh by Molmil
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Delta (B.1.617.2) variant 3 closed RBDs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ke, Z, Briggs, J.A.G.
Deposit date:2024-07-22
Release date:2024-11-27
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
Embo J., 43, 2024
9CRI
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BU of 9cri by Molmil
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: Mu (B.1.621) variant 3 closed RBDs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ke, Z, Briggs, J.A.G.
Deposit date:2024-07-22
Release date:2024-11-27
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants.
Embo J., 43, 2024
8R6E
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BU of 8r6e by Molmil
SARS-CoV-2 Nucleocapsid dimerization domain
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Fahoum, J, Wiener, R, Rouvinski, A, Isupov, M.N.
Deposit date:2023-11-22
Release date:2024-12-04
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:SARS-CoV-2 Nucleocapsid dimerization domain
To Be Published
8RNE
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BU of 8rne by Molmil
HLA-E*01:03 in complex with SARS-CoV-2 Nsp13 peptide, VMPLSAPTL
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, E alpha chain variant, ...
Authors:Sun, R, Achour, A, Sala, B.M, Sandalova, T.
Deposit date:2024-01-09
Release date:2024-12-04
Last modified:2025-01-22
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
Plos Pathog., 20, 2024
8RNF
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BU of 8rnf by Molmil
HLA-E*01:03 in complex with SARS-CoV-2 Omicron Nsp13 peptide, VIPLSAPTL
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, E alpha chain variant, ...
Authors:Sun, R, Achour, A, Sala, B.M, Sandalova, T.
Deposit date:2024-01-09
Release date:2024-12-04
Last modified:2025-01-22
Method:X-RAY DIFFRACTION (1.872 Å)
Cite:Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
Plos Pathog., 20, 2024
8USZ
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BU of 8usz by Molmil
Cryo-EM Structure of Full-Length Spike Protein of Omicron XBB.1.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Huynh, K.W, Chang, J.S, Fennell, K.F, Che, Y, Wu, H.
Deposit date:2023-10-30
Release date:2024-12-04
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Preclinical characterization of the Omicron XBB.1.5-adapted BNT162b2 COVID-19 vaccine.
Npj Vaccines, 9, 2024
8XKO
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BU of 8xko by Molmil
CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2
Descriptor: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
Authors:Li, M, An, L, Hong, Y, Li, S, Zhang, K.
Deposit date:2023-12-23
Release date:2024-12-04
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
Nat Commun, 15, 2024
8YX5
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BU of 8yx5 by Molmil
Crystal Structure of SARS CoV-2 Papain-like Protease PLpro-C111S in Complex with GZNL-P35
Descriptor: 5-[(1~{R},5~{S})-3,6-diazabicyclo[3.1.1]heptan-3-yl]-2-methyl-~{N}-[1-(1-methyl-2-oxidanylidene-benzo[cd]indol-6-yl)cyclopropyl]benzamide, GLYCEROL, Papain-like protease nsp3, ...
Authors:Lu, Y, Shang, J.
Deposit date:2024-04-02
Release date:2024-12-04
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19.
Nat Commun, 15, 2024
9B82
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BU of 9b82 by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COVA2-15 antibody heavy chain, COVA2-15 antibody light chain, ...
Authors:Yuan, M, Zhu, X, Wilson, I.A.
Deposit date:2024-03-28
Release date:2024-12-04
Last modified:2025-01-08
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.
Plant Biotechnol J, 23, 2025
8RBY
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BU of 8rby by Molmil
The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.26
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Camel-derived nanobody 1.26, ...
Authors:Casasnovas, J.M, Fernandez, L.A, Silva, K.
Deposit date:2023-12-05
Release date:2024-12-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.26
To Be Published

238582

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