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新型コロナウイルスの構造情報

このページの他言語版もあります: English简体中文繁體中文한국어
コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症（Novel Coronavirus disease 2019: COVID-19）の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）を理解し有効な薬を開発するため，関連するタンパク質の構造研究は既に始まっています。そして，解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため，新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは，同じ著者によるグループ登録のエントリーも全て区別し，すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており，アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは，今週公開された最も新しいエントリーです。

作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
全エントリー (5214)代表構造 (2274)最新のエントリー (7)
9MPW
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BU of 9mpw by Molmil
SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab M15 Heavy Chain, ...
著者Sapse, I.A, Bajic, G.
登録日2024-12-31
公開日2025-07-09
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献SARS-CoV2 Spike S2 Subunit in complex with M15 Antibody Fragment
To Be Published
9RCZ
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BU of 9rcz by Molmil
Structure of the N-terminal domain of non-structural protein 1 (Nsp1) from SARS-CoV-2
分子名称: ORF1a polyprotein
著者Lennartz, F, Weiss, M.S.
登録日2025-05-30
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystallographic fragment screening against SARS-CoV-2 Nsp1 using the F2X-Entry Screen and a newly developed fragment library.
To Be Published
9RHS
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BU of 9rhs by Molmil
Structure of 3CL protease with a bound inhibitor
分子名称: 3C-like proteinase nsp5, ~{N}-(4-bromanyl-3-nitro-phenyl)-2-(1,2,3-triazol-1-yl)ethanamide
著者Mac Sweeney, A.
登録日2025-06-10
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.638 Å)
主引用文献SARS-CoV-2 3CL protease with a bound inhibitor
To Be Published
9RHT
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BU of 9rht by Molmil
Structure of 3CL protease with a bound inhibitor
分子名称: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, SODIUM ION, ...
著者Mac Sweeney, A.
登録日2025-06-10
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.624 Å)
主引用文献SARS-CoV-2 3CL protease with a bound inhibitor
To Be Published
9RHX
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BU of 9rhx by Molmil
SARS-CoV-2 main protease with a bound inhibitor
分子名称: 2-pyridin-3-ylquinazoline, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Mac Sweeney, A.
登録日2025-06-10
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献SARS-CoV-2 main protease with a bound inhibitor
To Be Published
9RI0
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BU of 9ri0 by Molmil
SARS-CoV-2 3CL protease with a bound inhibitor
分子名称: 1,2-ETHANEDIOL, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Mac Sweeney, A.
登録日2025-06-10
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献SARS-CoV-2 3CL protease with a bound inhibitor
To Be Published
9RI1
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BU of 9ri1 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: (4~{R})-~{N}-(3,4-dipropoxyphenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase nsp5, BROMIDE ION, ...
著者Mac Sweeney, A.
登録日2025-06-10
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.309 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RI3
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BU of 9ri3 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, SODIUM ION, ...
著者Mac Sweeney, A.
登録日2025-06-11
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.723 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RI4
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BU of 9ri4 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 2-azanyl-~{N}-[(1~{R},2~{S})-2-(4-chloranyl-3-fluoranyl-phenyl)cyclopropyl]-6-nitro-benzamide, 3C-like proteinase nsp5, SODIUM ION
著者Mac Sweeney, A.
登録日2025-06-11
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.762 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RI5
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BU of 9ri5 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 3C-like proteinase nsp5, SULFATE ION, ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-2-pyridin-3-yl-~{N}-(thiophen-2-ylmethyl)ethanamide
著者Mac Sweeney, A.
登録日2025-06-11
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.634 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RI8
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BU of 9ri8 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 3C-like proteinase nsp5, 4-(azetidin-1-yl)-2-isoquinolin-4-yl-thieno[2,3-d]pyrimidine, DIMETHYL SULFOXIDE, ...
著者Mac Sweeney, A.
登録日2025-06-11
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.781 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RID
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BU of 9rid by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: (2~{R})-2-[2-(benzotriazol-1-yl)ethanoyl-methyl-amino]-2-(3-fluorophenyl)ethanamide, 3C-like proteinase nsp5, SODIUM ION, ...
著者Mac Sweeney, A.
登録日2025-06-11
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RIX
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BU of 9rix by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: (4~{R})-~{N}-[2-(1-benzothiophen-3-yl)ethyl]-7-fluoranyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoline-4-carboxamide, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RIY
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BU of 9riy by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, SODIUM ION, ...
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.788 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RIZ
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BU of 9riz by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: (4~{R})-~{N}-(3-cyclopropylphenyl)-2-oxidanylidene-3,4-dihydro-1~{H}-1,8-naphthyridine-4-carboxamide, 3C-like proteinase nsp5
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.734 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RJ0
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BU of 9rj0 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 1-(benzimidazol-1-yl)-3-[(4~{S})-6-fluoranyl-3,4-dihydro-2~{H}-thiochromen-4-yl]urea, 3C-like proteinase nsp5, SODIUM ION
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.709 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RJ3
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BU of 9rj3 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: (2~{R})-1-[3-(aminomethyl)-1,2,4-triazol-1-yl]-3-[2,5-bis(chloranyl)phenoxy]propan-2-ol, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.618 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RJ5
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BU of 9rj5 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 1-(2-cyclohexylethyl)-3-cyclopropyl-1-[(5-methyl-1,2-oxazol-3-yl)methyl]urea, 3C-like proteinase nsp5
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RJ7
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BU of 9rj7 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 3C-like proteinase nsp5, 4-fluoranyl-~{N}-(pyridin-3-ylmethyl)-2,3-dihydroindole-1-carboxamide, SODIUM ION
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.897 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RJ8
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BU of 9rj8 by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 3C-like proteinase nsp5, 4-fluoranyl-~{N}-(3-phenoxypropyl)-~{N}-(1,2-thiazol-5-ylmethyl)-2,3-dihydroindole-1-carboxamide
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.433 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RJF
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BU of 9rjf by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 3-(5-bromanylpyridin-3-yl)-1-[(1~{R})-1-phenylethyl]imidazolidine-2,4-dione, 3C-like proteinase nsp5
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.893 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
9RJR
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BU of 9rjr by Molmil
SARS-CoV-2 with a bound inhibitor
分子名称: 1-[[3,4-bis(fluoranyl)phenyl]methyl]-3-(5-bromanylpyridin-3-yl)imidazolidine-2,4-dione, 3C-like proteinase nsp5, SODIUM ION, ...
著者Mac Sweeney, A.
登録日2025-06-12
公開日2025-07-09
実験手法X-RAY DIFFRACTION (1.705 Å)
主引用文献SARS-CoV-2 with a bound inhibitor
To Be Published
8XTD
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BU of 8xtd by Molmil
SARS-CoV-2 papain-like-protease (PLpro) in complex with inhibitor Linagliptin
分子名称: 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, GLYCEROL, Non-structural protein 3
著者Choudhary, S, Verma, S, Kumar, P, Tomar, S.
登録日2024-01-10
公開日2025-07-16
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献SARS-CoV-2 papain-like-protease (PLpro) in complex with inhibitor Linagliptin
To Be Published
9HFX
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BU of 9hfx by Molmil
Crystal structure of SARS CoV-2 3CLpro (Mpro) with ALG-097558
分子名称: (1~{S},2~{S},3~{S},6~{R},7~{R})-~{N}-[(2~{S})-1-azanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-4-[(2~{S})-2-[[2-chloranyl-2,2-bis(fluoranyl)ethanoyl]amino]-3,3-dimethyl-butanoyl]-4-azatricyclo[5.2.1.0^{2,6}]decane-3-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5
著者Tauchert, M.J, Maskos, K, McGowan, D.C, Stoycheva, A.D.
登録日2024-11-18
公開日2025-07-16
最終更新日2025-07-23
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
J.Med.Chem., 68, 2025
9HFY
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BU of 9hfy by Molmil
Crystal structure of SARS CoV-2 3CLpro (Mpro) with ALG-097078
分子名称: (3~{S},3~{a}~{S},6~{a}~{R})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonyl]-~{N}-[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5
著者Tauchert, M.J, Maskos, K, McGowan, D.C, Stoycheva, A.D.
登録日2024-11-18
公開日2025-07-16
最終更新日2025-07-23
実験手法X-RAY DIFFRACTION (1.282 Å)
主引用文献Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
J.Med.Chem., 68, 2025

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件を2025-07-23に公開中

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