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新型コロナウイルスの構造情報

このページの他言語版もあります: English简体中文繁體中文한국어
コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症（Novel Coronavirus disease 2019: COVID-19）の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）を理解し有効な薬を開発するため，関連するタンパク質の構造研究は既に始まっています。そして，解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため，新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは，同じ著者によるグループ登録のエントリーも全て区別し，すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており，アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは，今週公開された最も新しいエントリーです。

作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
全エントリー (5197)代表構造 (2266)最新のエントリー (44)
9BS8
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BU of 9bs8 by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor YR-B-107
分子名称: 3C-like proteinase nsp5, benzyl (7S)-7-({(2R)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamoyl)-6-azaspiro[3.4]octane-6-carboxylate
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSA
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BU of 9bsa by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor VB-B-112
分子名称: 2,2-dichloro-N-(5-chloropyridin-3-yl)-N-phenylacetamide, 3C-like proteinase nsp5
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSE
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BU of 9bse by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor YR-B-165
分子名称: (3S)-N-{(2S)-1-amino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-2-[(2R)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-2-azaspiro[4.5]decane-3-carboxamide, 3C-like proteinase nsp5
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSF
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BU of 9bsf by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor SR-A-171
分子名称: 3C-like proteinase nsp5, N-(4-tert-butylphenyl)-2,2-dichloro-N-(5-chloropyridin-3-yl)acetamide
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSG
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BU of 9bsg by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor VB-C-20
分子名称: 3C-like proteinase nsp5, methyl 4-[(5-chloropyridin-3-yl)(phenyl)amino]-4-oxobutanoate
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSI
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BU of 9bsi by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor SR-B-7
分子名称: 3C-like proteinase nsp5, N-[(1M)-3'-chloro[1,1'-biphenyl]-3-yl]-N-(5-chloropyridin-3-yl)-2-fluoroacetamide
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSO
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BU of 9bso by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor SR-B-13
分子名称: 3C-like proteinase nsp5, N-[(1M)-3'-chloro[1,1'-biphenyl]-3-yl]-N-(5-chloropyridin-3-yl)-3-sulfanylpropanamide
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSP
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BU of 9bsp by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor VB-C-68
分子名称: 3C-like proteinase nsp5, methyl 4-{[(1M)-3'-chloro[1,1'-biphenyl]-3-yl](5-chloropyridin-3-yl)amino}-4-oxobutanoate
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSQ
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BU of 9bsq by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor VB-C-70
分子名称: (2R)-N-[(1M)-3'-chloro[1,1'-biphenyl]-3-yl]-N-(5-chloropyridin-3-yl)-2-hydroxy-2-sulfanylacetamide, 3C-like proteinase nsp5
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BSR
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BU of 9bsr by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor YR-B-136B
分子名称: (1R,2S,5R)-N-[(1R)-1-(7-fluoroisoquinolin-4-yl)-2-iminoethyl]-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9BST
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BU of 9bst by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor CID8009_5647
分子名称: 3C-like proteinase nsp5, [3-[2,6-bis(chloranyl)phenyl]-5-methyl-1,2-oxazol-4-yl]methanol
著者Blankenship, L.R, Liu, W.R.
登録日2024-05-13
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of the SARS-CoV-2 main protease
To Be Published
9C2H
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BU of 9c2h by Molmil
SARS-CoV-2 Nucleocapsid Dimerization Domain bound to Fab-NP1E9 and Fab-NP3B4
分子名称: Antibody Fab NP1-E9 Heavy Chain (variable region), Antibody Fab NP1-E9 Light Chain (variable region), Antibody Fab NP3-B4 Heavy Chain (variable region), ...
著者Landeras-Bueno, S, Hariharan, C, Diaz Avalos, R, Ollmann Saphire, E.
登録日2024-05-31
公開日2025-05-14
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural stabilization of the intrinsically disordered SARS-CoV-2 N by binding to RNA sequences engineered from the viral genome
To Be Published
9F7P
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BU of 9f7p by Molmil
SARS-CoV-2 papain-like protease (PLpro) C112S mutant
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MALONATE ION, ...
著者Camara-Artigas, A.
登録日2024-05-04
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献SARS-CoV-2 papain-like protease (PLpro) C112S mutant
To Be Published
9F7Q
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BU of 9f7q by Molmil
SARS-CoV-2 papain-like protease (PLpro) C112S mutant
分子名称: GLYCEROL, Replicase polyprotein 1ab, SULFATE ION, ...
著者Camara-Artigas, A.
登録日2024-05-04
公開日2025-05-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献SARS-CoV-2 papain-like protease (PLpro) C112S mutant
To Be Published
9F7R
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BU of 9f7r by Molmil
SARS-CoV-2 papain-like protease (PLpro) C112S mutant
分子名称: GLYCEROL, PHOSPHATE ION, Replicase polyprotein 1ab, ...
著者Camara-Artigas, A.
登録日2024-05-04
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献SARS-CoV-2 papain-like protease (PLpro) C112S mutant
To Be Published
9F7S
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BU of 9f7s by Molmil
SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-K229R mutant
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MALONATE ION, ...
著者Camara-Artigas, A.
登録日2024-05-04
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-K229R mutant
To Be Published
9F7T
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BU of 9f7t by Molmil
SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-K229R mutant: dimer
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Replicase polyprotein 1ab, ...
著者Camara-Artigas, A.
登録日2024-05-04
公開日2025-05-14
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-K229R mutant
To Be Published
9F7U
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BU of 9f7u by Molmil
SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-Q222D-K229R-Q230R-C271S mutant
分子名称: CHLORIDE ION, GLYCEROL, MALONIC ACID, ...
著者Camara-Artigas, A.
登録日2024-05-05
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-Q222D-K229R-Q230R-C271S mutant
To Be Published
9F7Y
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BU of 9f7y by Molmil
SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-Q222D-K229R-Q230R-C271S mutant
分子名称: CHLORIDE ION, MALONIC ACID, Replicase polyprotein 1ab, ...
著者Camara-Artigas, A.
登録日2024-05-05
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献SARS-CoV-2 papain-like protease (PLpro) C112S-K191D-Q222D-K229R-Q230R-C271S mutant
To Be Published
9LVR
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BU of 9lvr by Molmil
Crystal structure of SARS-CoV-2 3CL protease in complex with compound 1
分子名称: 1,2-ETHANEDIOL, 3C-like proteinase nsp5, 6-(1,3-dihydroisoindol-2-yl)-3-(5-methylpyridin-3-yl)-1-[[3,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione
著者Unoh, Y, Hirai, K, Uehara, S, Kawashima, S, Nobori, H, Sato, J, Shibayama, H, Hori, A, Nakahara, K, Kurahashi, K, Takamatsu, M, Yamamoto, S, Zhang, O, Tanimura, M, Dodo, R, Maruyama, Y, Sawa, H, Watari, R, Miyano, T, Kato, T, Sato, T, Tachibana, Y.
登録日2025-02-12
公開日2025-05-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of The Clinical Candidate S-892216: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19
To Be Published
9LVT
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BU of 9lvt by Molmil
Crystal structure of SARS-CoV-2 3CL protease in complex with compound 4
分子名称: 1-(2-azanylideneethyl)-6-(1,3-dihydroisoindol-2-yl)-3-(5-methylpyridin-3-yl)-5-[[3,4,5-tris(fluoranyl)phenyl]methyl]pyrimidine-2,4-dione, 3C-like proteinase
著者Unoh, Y, Hirai, K, Uehara, S, Kawashima, S, Nobori, H, Sato, J, Shibayama, H, Hori, A, Nakahara, K, Kurahashi, K, Takamatsu, M, Yamamoto, S, Zhang, O, Tanimura, M, Dodo, R, Maruyama, Y, Sawa, H, Watari, R, Miyano, T, Kato, T, Sato, T, Tachibana, Y.
登録日2025-02-12
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of The Clinical Candidate S-892216: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19
To Be Published
9LVV
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BU of 9lvv by Molmil
Crystal structure of SARS-CoV-2 3CL protease in complex with compound 17 (S-892216)
分子名称: 1-(2-azanylideneethyl)-6-[6,6-bis(fluoranyl)-2-azaspiro[3.3]heptan-2-yl]-5-(3-chloranyl-4-fluoranyl-phenyl)-3-(5-chloranylpyridin-3-yl)pyrimidine-2,4-dione, 3C-like proteinase
著者Unoh, Y, Hirai, K, Uehara, S, Kawashima, S, Nobori, H, Sato, J, Shibayama, H, Hori, A, Nakahara, K, Kurahashi, K, Takamatsu, M, Yamamoto, S, Zhang, O, Tanimura, M, Dodo, R, Maruyama, Y, Sawa, H, Watari, R, Miyano, T, Kato, T, Sato, T, Tachibana, Y.
登録日2025-02-12
公開日2025-05-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of The Clinical Candidate S-892216: A Second-Generation of SARS-CoV-2 3CL Protease Inhibitor for Treating COVID-19
To Be Published
7I13
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BU of 7i13 by Molmil
PanDDA analysis group deposition -- Main Protease (SARS-CoV-2) in complex with fragment B05 from the F2X-Entry Screen in orthorhombic space group
分子名称: 2-acetylbenzoic acid, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Barthel, T, Benz, L.S, Wollenhaupt, J, Weiss, M.S.
登録日2025-02-03
公開日2025-05-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Orthorhombic SARS-CoV-2 main protease crystals provide higher success rate in fragment screening
To be published
7I14
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BU of 7i14 by Molmil
PanDDA analysis group deposition -- Main Protease (SARS-CoV-2) in complex with fragment B08 from the F2X-Entry Screen in orthorhombic space group
分子名称: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ethyl 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate
著者Barthel, T, Benz, L.S, Wollenhaupt, J, Weiss, M.S.
登録日2025-02-03
公開日2025-05-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Orthorhombic SARS-CoV-2 main protease crystals provide higher success rate in fragment screening
To be published
7I15
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BU of 7i15 by Molmil
PanDDA analysis group deposition -- Main Protease (SARS-CoV-2) in complex with fragment C02 from the F2X-Entry Screen in orthorhombic space group
分子名称: 2,4,5-tris(fluoranyl)-3-methoxy-benzoic acid, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Barthel, T, Benz, L.S, Wollenhaupt, J, Weiss, M.S.
登録日2025-02-03
公開日2025-05-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Orthorhombic SARS-CoV-2 main protease crystals provide higher success rate in fragment screening
To be published

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件を2025-07-09に公開中

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