8R6E
 
 | | SARS-CoV-2 Nucleocapsid dimerization domain | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Fahoum, J, Wiener, R, Rouvinski, A, Isupov, M.N. | | 登録日 | 2023-11-22 | | 公開日 | 2024-12-04 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | SARS-CoV-2 Nucleocapsid dimerization domain
To Be Published
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8RNE
 | | HLA-E*01:03 in complex with SARS-CoV-2 Nsp13 peptide, VMPLSAPTL | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, E alpha chain variant, ... | | 著者 | Sun, R, Achour, A, Sala, B.M, Sandalova, T. | | 登録日 | 2024-01-09 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-01-22 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
Plos Pathog., 20, 2024
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8RNF
 | | HLA-E*01:03 in complex with SARS-CoV-2 Omicron Nsp13 peptide, VIPLSAPTL | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, E alpha chain variant, ... | | 著者 | Sun, R, Achour, A, Sala, B.M, Sandalova, T. | | 登録日 | 2024-01-09 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-01-22 | | 実験手法 | X-RAY DIFFRACTION (1.872 Å) | | 主引用文献 | Emerging mutation in SARS-CoV-2 facilitates escape from NK cell recognition and associates with enhanced viral fitness.
Plos Pathog., 20, 2024
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8USZ
 | | Cryo-EM Structure of Full-Length Spike Protein of Omicron XBB.1.5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Huynh, K.W, Chang, J.S, Fennell, K.F, Che, Y, Wu, H. | | 登録日 | 2023-10-30 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Preclinical characterization of the Omicron XBB.1.5-adapted BNT162b2 COVID-19 vaccine.
Npj Vaccines, 9, 2024
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8XKO
 | | CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2 | | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Li, M, An, L, Hong, Y, Li, S, Zhang, K. | | 登録日 | 2023-12-23 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode.
Nat Commun, 15, 2024
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8YX2
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8YX3
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8YX4
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8YX5
 | | Crystal Structure of SARS CoV-2 Papain-like Protease PLpro-C111S in Complex with GZNL-P35 | | 分子名称: | 5-[(1~{R},5~{S})-3,6-diazabicyclo[3.1.1]heptan-3-yl]-2-methyl-~{N}-[1-(1-methyl-2-oxidanylidene-benzo[cd]indol-6-yl)cyclopropyl]benzamide, GLYCEROL, Papain-like protease nsp3, ... | | 著者 | Lu, Y, Shang, J. | | 登録日 | 2024-04-02 | | 公開日 | 2024-12-04 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19.
Nat Commun, 15, 2024
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9B82
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-15 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COVA2-15 antibody heavy chain, COVA2-15 antibody light chain, ... | | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | | 登録日 | 2024-03-28 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-01-08 | | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | | 主引用文献 | Plant-produced SARS-CoV-2 antibody engineered towards enhanced potency and in vivo efficacy.
Plant Biotechnol J, 23, 2025
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9GLV
 | | Crystal structure of SARS-CoV-2 Mpro with AB-343. | | 分子名称: | (1S,3S,4S)-N-[(2S)-1-azanylidene-3-[(3S)-5,5-dimethyl-2-oxidanylidene-pyrrolidin-3-yl]propan-2-yl]-2-[(2R)-3-cyclobutyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]propanoyl]-5,5-bis(fluoranyl)-2-azabicyclo[2.2.2]octane-3-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... | | 著者 | Prasad, A, Blaesse, M, Maskos, K, Steinbacher, S, Konz Makino, D.L. | | 登録日 | 2024-08-28 | | 公開日 | 2024-12-04 | | 最終更新日 | 2024-12-11 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Biological characterization of AB-343, a novel and potent SARS-CoV-2 M pro inhibitor with pan-coronavirus activity.
Antiviral Res., 232, 2024
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9GUD
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and theophylline derivative LAS 54570922 | | 分子名称: | (3~{S})-3-azanyl-4-[(3~{R},4~{R},6~{S})-3-[1,3-dimethyl-2,6-bis(oxidanylidene)purin-7-yl]-4-methyl-4,6-bis(oxidanyl)azepan-1-yl]-4-oxidanylidene-butanoic acid, 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, ... | | 著者 | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | 登録日 | 2024-09-19 | | 公開日 | 2024-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders
To Be Published
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9GUY
 | | SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and theophylline derivative LAS 54571098 | | 分子名称: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | 著者 | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | | 登録日 | 2024-09-20 | | 公開日 | 2024-12-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders
To Be Published
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9HAK
 | | Structure of compound 119 bound to SARS-CoV-2 main protease | | 分子名称: | (5~{R})-4-[(4-bromanyl-2-ethyl-phenyl)methyl]-~{N}-ethyl-1-thieno[2,3-c]pyridin-4-ylcarbonyl-1,4-diazepane-5-carboxamide, 3C-like proteinase nsp5, CHLORIDE ION, ... | | 著者 | Mac Sweeney, A, Hazemann, J. | | 登録日 | 2024-11-04 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Accelerating the Hit-To-Lead Optimization of a SARS-CoV-2 Mpro Inhibitor Series by Combining High-Throughput Medicinal Chemistry and Computational Simulations.
J.Med.Chem., 68, 2025
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8RBY
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8XEF
 | | Cocktail GC2050-GC2225 | | 分子名称: | GC2050 heavy chain, GC2050 light chain, GC2225 heavy chain, ... | | 著者 | Feng, L.L. | | 登録日 | 2023-12-11 | | 公開日 | 2024-12-11 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.41 Å) | | 主引用文献 | XBB.1.5 RBD in complex with GC2050 and GC2225
To Be Published
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9CJ6
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9HJH
 | | Structure of compound 1 bound to SARS-CoV-2 main protease | | 分子名称: | (2~{R})-4-[(4-bromanyl-2-ethyl-phenyl)methyl]-1-(5-chloranylpyridin-3-yl)carbonyl-~{N}-ethyl-1,4-diazepane-2-carboxamide, 1,2-ETHANEDIOL, 3C-like proteinase nsp5, ... | | 著者 | Mac Sweeney, A, Hazemann, J. | | 登録日 | 2024-11-29 | | 公開日 | 2024-12-11 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Accelerating the Hit-To-Lead Optimization of a SARS-CoV-2 Mpro Inhibitor Series by Combining High-Throughput Medicinal Chemistry and Computational Simulations.
J.Med.Chem., 68, 2025
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8JAP
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8TYK
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8V5V
 | | Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2,Fibritin, ... | | 著者 | Olmedillas, E, Diaz, R, Hastie, K, Ollmann-Saphire, E. | | 登録日 | 2023-12-01 | | 公開日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation
To Be Published
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8XRQ
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9BIH
 | | SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA with 1 nucleotide bulge | | 分子名称: | RNA (34-mer), RNA (35-mer), Uridylate-specific endoribonuclease nsp15 | | 著者 | Wright, Z.M, Butay, K.J, Krahn, J.M, Borgnia, M.J, Stanley, R.E. | | 登録日 | 2024-04-23 | | 公開日 | 2024-12-18 | | 最終更新日 | 2025-01-15 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Spontaneous base flipping helps drive Nsp15's preferences in double stranded RNA substrates.
Nat Commun, 16, 2025
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8UDF
 | | Crystal structure of SARS-CoV-2 3CL protease with inhibitor DEL_7 | | 分子名称: | 2-cyano-D-phenylalanyl-2,4-dichloro-N-[(2S)-1-(4-fluorophenyl)-4-(methylamino)-4-oxobutan-2-yl]-D-phenylalaninamide, 3C-like proteinase nsp5, CHLORIDE ION, ... | | 著者 | Forouhar, F, Liu, H, Zack, A, Iketani, S, Williams, A, Vaz, D.R, Habashi, D.L, Resnick, S.J, Chavez, A, Ho, D.D, Stockwell, B.R. | | 登録日 | 2023-09-28 | | 公開日 | 2024-12-25 | | 最終更新日 | 2025-01-15 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening.
Nat Commun, 16, 2025
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8UDJ
 | | Crystal structure of SARS-CoV-2 3CL protease with inhibitor DEL_2 | | 分子名称: | 2-cyano-D-phenylalanyl-2,4-dichloro-N-[(2S)-4-(methylamino)-4-oxo-1-phenylbutan-2-yl]-D-phenylalaninamide, 3C-like proteinase nsp5 | | 著者 | Forouhar, F, Liu, H, Zack, A, Iketani, S, Williams, A, Vaz, D.R, Habashi, D.L, Resnick, S.J, Chavez, A, Ho, D.D, Stockwell, B.R. | | 登録日 | 2023-09-28 | | 公開日 | 2024-12-25 | | 最終更新日 | 2025-01-15 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening.
Nat Commun, 16, 2025
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