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新型コロナウイルスの構造情報

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コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
7GRU
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BU of 7gru by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-17
分子名称: 3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-amine, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GRV
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BU of 7grv by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-18
分子名称: (2S)-2-(2-fluorophenyl)-1,3-thiazolidin-4-one, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GRW
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BU of 7grw by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-19
分子名称: (2S)-N-(3,5-dichlorophenyl)-2-hydroxypropanamide, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GRX
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BU of 7grx by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-20
分子名称: 1-(2,4-difluorophenyl)pyrrolidine-2,5-dione, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GRY
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BU of 7gry by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-21
分子名称: 1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GRZ
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BU of 7grz by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-22
分子名称: 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, N,N-dimethyl-2-[(naphthalen-2-yl)oxy]acetamide, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GS0
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BU of 7gs0 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-23
分子名称: (pyridin-2-yl)(quinolin-2-yl)methanone, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GS1
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BU of 7gs1 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-24
分子名称: 2-cyano-~{N}-cyclohexyl-ethanamide, 3C-like proteinase nsp5, CHLORIDE ION, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GS2
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BU of 7gs2 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-25
分子名称: 3-(pyridin-3-yl)benzoic acid, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GS3
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BU of 7gs3 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-26
分子名称: (6-phenylpyridin-3-yl)methanamine, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GS4
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BU of 7gs4 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-27
分子名称: 3C-like proteinase nsp5, 7-(hydroxymethyl)-3-methyl-6~{H}-[1,3]thiazolo[3,2-a]pyrimidin-5-one, CHLORIDE ION, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GS5
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BU of 7gs5 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-28
分子名称: (3R)-5-fluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
7GS6
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BU of 7gs6 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with cpd-29
分子名称: (3S)-4,7-dichloro-3-hydroxy-1,3-dihydro-2H-indol-2-one, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ...
著者Huang, C.-Y, Metz, A, Sharpe, M, Sweeney, A.
登録日2023-11-14
公開日2024-02-14
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Acta Crystallogr D Struct Biol, 80, 2024
8RV4
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BU of 8rv4 by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 2
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-2-phenyl-benzoic acid, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RV5
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BU of 8rv5 by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 1
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RV6
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BU of 8rv6 by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 2
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-(4-hydroxyphenyl)benzoic acid, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RV7
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BU of 8rv7 by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 4
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-5-(3-oxidanylprop-1-ynyl)benzoic acid, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RV8
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BU of 8rv8 by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 5
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]-2-chloranyl-benzoic acid, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RV9
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BU of 8rv9 by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 6
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]-2-chloranyl-benzoic acid, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RVA
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BU of 8rva by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 7
分子名称: 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanylmethyl]benzoic acid, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8RVB
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BU of 8rvb by Molmil
SARS-CoV-2 nsp16-nsp10 in complex with SAM derivative inhibitor 8
分子名称: (2~{R},3~{R},4~{S},5~{S})-2-(6-aminopurin-9-yl)-5-[2-(1~{H}-1,2,3-triazol-4-yl)ethylsulfanylmethyl]oxolane-3,4-diol, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Kalnins, G.
登録日2024-01-31
公開日2024-02-14
最終更新日2025-01-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Basis for Inhibition of the SARS-CoV-2 nsp16 by Substrate-Based Dual Site Inhibitors.
Chemmedchem, 19, 2024
8UIA
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BU of 8uia by Molmil
Crystal structure of SARS CoV-2 3CL protease in complex with GSK4365097A
分子名称: 3C-like proteinase nsp5, CHLORIDE ION, GLYCEROL, ...
著者Concha, N.O, Williams, S.P.
登録日2023-10-10
公開日2024-02-14
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg.Med.Chem., 100, 2024
8UIF
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BU of 8uif by Molmil
Crystal structure of SARS CoV-2 3CL protease in complex with GSK4365096A
分子名称: 3C-like proteinase nsp5, N-[(benzyloxy)carbonyl]-4-fluoro-L-phenylalanyl-N-{(2R)-1-[(2S)-oxolan-2-yl]-3-[(3S)-2-oxooxolan-3-yl]propan-2-yl}-L-leucinamide
著者Concha, N.O, Williams, S.P.
登録日2023-10-10
公開日2024-02-14
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg.Med.Chem., 100, 2024
8VKK
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BU of 8vkk by Molmil
Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S.
登録日2024-01-09
公開日2024-02-14
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (2.81 Å)
主引用文献Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
Nat Commun, 15, 2024
8VKL
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BU of 8vkl by Molmil
Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (conformation 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S.
登録日2024-01-09
公開日2024-02-14
最終更新日2025-02-26
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
Nat Commun, 15, 2024

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件を2025-07-09に公開中

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