Entry Database : PDB / ID : 6i8t Structure visualization Downloads & linksTitle THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH AN ISOINDOLINONE INHIBITOR ComponentsPoly [ADP-ribose] polymerase 1 Details Keywords TRANSFERASE / CHICKEN PARP1 / INHIBITOR COMPLEX / ADP-RIBOSYLATION / DNA DAMAGEFunction / homology Function and homology informationFunction Domain/homology Component
NAD+-protein-tyrosine ADP-ribosyltransferase activity / NAD+-protein-histidine ADP-ribosyltransferase activity / NAD+-protein-serine ADP-ribosyltransferase activity / NAD+-protein-aspartate ADP-ribosyltransferase activity / NAD+-protein-glutamate ADP-ribosyltransferase activity / DNA ADP-ribosylation / ATP generation from poly-ADP-D-ribose / replication fork reversal / NAD+ ADP-ribosyltransferase / protein auto-ADP-ribosylation ... NAD+-protein-tyrosine ADP-ribosyltransferase activity / NAD+-protein-histidine ADP-ribosyltransferase activity / NAD+-protein-serine ADP-ribosyltransferase activity / NAD+-protein-aspartate ADP-ribosyltransferase activity / NAD+-protein-glutamate ADP-ribosyltransferase activity / DNA ADP-ribosylation / ATP generation from poly-ADP-D-ribose / replication fork reversal / NAD+ ADP-ribosyltransferase / protein auto-ADP-ribosylation / protein poly-ADP-ribosylation / nuclear replication fork / NAD+-protein ADP-ribosyltransferase activity / NAD+-protein poly-ADP-ribosyltransferase activity / Transferases; Glycosyltransferases; Pentosyltransferases / positive regulation of double-strand break repair via homologous recombination / nucleosome binding / negative regulation of innate immune response / nucleotidyltransferase activity / NAD binding / double-strand break repair / site of double-strand break / damaged DNA binding / innate immune response / chromatin / nucleolus / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / zinc ion binding / cytosol Similarity search - Function : / PADR1, N-terminal helical domain / PADR1 domain profile. / Poly [ADP-ribose] polymerase / PADR1 domain / PADR1 domain superfamily / PADR1 domain, zinc ribbon fold / PADR1 / Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. / Zinc finger, PARP-type superfamily ... : / PADR1, N-terminal helical domain / PADR1 domain profile. / Poly [ADP-ribose] polymerase / PADR1 domain / PADR1 domain superfamily / PADR1 domain, zinc ribbon fold / PADR1 / Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. / Zinc finger, PARP-type superfamily / Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region / Zinc finger poly(ADP-ribose) polymerase (PARP)-type profile. / Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region / Zinc finger, PARP-type / : / WGR domain profile. / Poly(ADP-ribose) polymerase, regulatory domain / WGR domain / WGR domain superfamily / WGR domain / Proposed nucleic acid binding domain / Poly(ADP-ribose) polymerase, regulatory domain superfamily / Poly(ADP-ribose) polymerase, regulatory domain / PARP alpha-helical domain profile. / Phosphoenolpyruvate Carboxykinase; domain 3 - #10 / Phosphoenolpyruvate Carboxykinase; domain 3 / BRCA1 C Terminus (BRCT) domain / Poly(ADP-ribose) polymerase catalytic domain / Poly(ADP-ribose) polymerase, catalytic domain / PARP catalytic domain profile. / breast cancer carboxy-terminal domain / BRCT domain profile. / BRCT domain / BRCT domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Gallus gallus (chicken)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.1 Å DetailsAuthors Casale, E. / Papeo, G. / Montagnoli, A. CitationJournal : Acs Med.Chem.Lett. / Year : 2019Title : Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515.Authors: Papeo, G. / Orsini, P. / Avanzi, N.R. / Borghi, D. / Casale, E. / Ciomei, M. / Cirla, A. / Desperati, V. / Donati, D. / Felder, E.R. / Galvani, A. / Guanci, M. / Isacchi, A. / Posteri, H. / ... Authors : Papeo, G. / Orsini, P. / Avanzi, N.R. / Borghi, D. / Casale, E. / Ciomei, M. / Cirla, A. / Desperati, V. / Donati, D. / Felder, E.R. / Galvani, A. / Guanci, M. / Isacchi, A. / Posteri, H. / Rainoldi, S. / Riccardi-Sirtori, F. / Scolaro, A. / Montagnoli, A. History Deposition Nov 21, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 1, 2019 Provider : repository / Type : Initial releaseRevision 1.1 May 15, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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