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Yorodumi- PDB-1tba: SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF ... -
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Entry | Database: PDB / ID: 1tba | ||||||
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Title | SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF THE MINOR GROOVE SURFACE OF THE TATA BOX UNWOUND BY TBP, NMR, 25 STRUCTURES | ||||||
Components |
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Keywords | COMPLEX (TRANSCRIPTION FACTORS) / TBP / TAF / TAFII230 / TFIID / SOLUTION STRUCTURE | ||||||
Function / homology | Function and homology information RNA Polymerase II Promoter Escape / RNA Polymerase II Transcription Pre-Initiation And Promoter Opening / RNA Polymerase II Transcription Initiation / RNA Polymerase II Transcription Initiation And Promoter Clearance / RNA Polymerase II Pre-transcription Events / Regulation of TP53 Activity through Phosphorylation / : / : / : / histone H3K14 acetyltransferase activity ...RNA Polymerase II Promoter Escape / RNA Polymerase II Transcription Pre-Initiation And Promoter Opening / RNA Polymerase II Transcription Initiation / RNA Polymerase II Transcription Initiation And Promoter Clearance / RNA Polymerase II Pre-transcription Events / Regulation of TP53 Activity through Phosphorylation / : / : / : / histone H3K14 acetyltransferase activity / ubiquitin activating enzyme activity / PRC1 complex / TFIIA-class transcription factor complex binding / transcription factor TFIIIB complex / RNA polymerase III preinitiation complex assembly / RNA polymerase III transcription regulatory region sequence-specific DNA binding / regulation of transcription by RNA polymerase III / histone H4 acetyltransferase activity / RNA polymerase I general transcription initiation factor binding / transcription factor TFIIA complex / RNA polymerase I preinitiation complex assembly / DNA binding, bending / : / RNA Polymerase III Transcription Initiation From Type 2 Promoter / RNA polymerase II transcribes snRNA genes / RNA Polymerase I Promoter Escape / Estrogen-dependent gene expression / RNA polymerase II general transcription initiation factor activity / RNA Polymerase II Promoter Escape / RNA Polymerase II Transcription Pre-Initiation And Promoter Opening / RNA Polymerase II Transcription Initiation / RNA Polymerase II Transcription Initiation And Promoter Clearance / transcription factor TFIID complex / RNA Polymerase II Pre-transcription Events / ubiquitin conjugating enzyme activity / nucleolar large rRNA transcription by RNA polymerase I / transcription factor binding / RNA polymerase II core promoter sequence-specific DNA binding / histone acetyltransferase activity / RNA polymerase II preinitiation complex assembly / TBP-class protein binding / transcription initiation at RNA polymerase II promoter / DNA-templated transcription initiation / disordered domain specific binding / DNA-binding transcription factor binding / transcription regulator complex / RNA polymerase II-specific DNA-binding transcription factor binding / sequence-specific DNA binding / non-specific serine/threonine protein kinase / cell cycle / protein phosphorylation / protein serine/threonine kinase activity / negative regulation of DNA-templated transcription / chromatin binding / nucleolus / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / ATP binding / nucleus Similarity search - Function | ||||||
Biological species | Drosophila melanogaster (fruit fly) Saccharomyces cerevisiae (brewer's yeast) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Liu, D. / Ishima, R. / Tong, K.I. / Bagby, S. / Kokubo, T. / Muhandiram, D.R. / Kay, L.E. / Nakatani, Y. / Ikura, M. | ||||||
Citation | Journal: Cell(Cambridge,Mass.) / Year: 1998 Title: Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP. Authors: Liu, D. / Ishima, R. / Tong, K.I. / Bagby, S. / Kokubo, T. / Muhandiram, D.R. / Kay, L.E. / Nakatani, Y. / Ikura, M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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PDBx/mmCIF format | 1tba.cif.gz | 1.8 MB | Display | PDBx/mmCIF format |
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PDB format | pdb1tba.ent.gz | 1.6 MB | Display | PDB format |
PDBx/mmJSON format | 1tba.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tb/1tba ftp://data.pdbj.org/pub/pdb/validation_reports/tb/1tba | HTTPS FTP |
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Similar structure data |
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Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 7012.671 Da / Num. of mol.: 1 / Fragment: RESIDUES 11-77 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Production host: Escherichia coli (E. coli) / References: UniProt: P51123 |
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#2: Protein | Mass: 20120.754 Da / Num. of mol.: 1 / Fragment: CORE DOMAIN RESIDUES 60-249 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Saccharomyces cerevisiae (brewer's yeast) Species (production host): Escherichia coli / Production host: Escherichia coli BL21 (bacteria) / Strain (production host): BL21 / References: UniProt: P13393 |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR details | Text: THE STRUCTURE WAS DETERMINED USING MULTIDIMENSIONAL HETERONUCLEAR NMR ON 13C, 15N AND 2H-LABELED TBP AND TAF |
-Sample preparation
Sample conditions | pH: 7.0 / Temperature: 298 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-Processing
Software |
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NMR software | Name: X-PLOR / Version: 3.851 / Developer: BRUNGER / Classification: refinement | ||||||||||||
NMR ensemble | Conformers submitted total number: 25 |