登録情報 | データベース: PDB / ID: 5kq4 |
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タイトル | Crystal structure of S. pombe Dcp1/Dcp2 in complex with H. sapiens PNRC2 and synthetic cap analog |
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要素 | - Proline-rich nuclear receptor coactivator 2
- mRNA decapping complex subunit 2
- mRNA-decapping enzyme subunit 1
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キーワード | HYDROLASE / decapping mRNA decay Nudix cap analog |
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機能・相同性 | 機能・相同性情報
mRNA phosphatase activator activity / RNA decapping complex / mRNA methylguanosine-cap decapping / deadenylation-independent decapping of nuclear-transcribed mRNA / 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity / 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity / 加水分解酵素 / deadenylation-dependent decapping of nuclear-transcribed mRNA / mRNA cap binding / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ...mRNA phosphatase activator activity / RNA decapping complex / mRNA methylguanosine-cap decapping / deadenylation-independent decapping of nuclear-transcribed mRNA / 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity / 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity / 加水分解酵素 / deadenylation-dependent decapping of nuclear-transcribed mRNA / mRNA cap binding / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / P-body / cytoplasmic stress granule / mRNA processing / manganese ion binding / single-stranded RNA binding / magnesium ion binding / Golgi apparatus / RNA binding / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Proline-rich nuclear receptor coactivator 1/2 / Proline-rich nuclear receptor coactivator motif / mRNA-decapping enzyme subunit 1 / Dcp1-like decapping family / mRNA decapping protein 2, Box A domain / mRNA decapping protein 2, Box A domain superfamily / mRNA decapping enzyme 2 , NUDIX hydrolase domain / Dcp2, box A domain / Dcp2, box A domain / NUDIX hydrolase, conserved site ...Proline-rich nuclear receptor coactivator 1/2 / Proline-rich nuclear receptor coactivator motif / mRNA-decapping enzyme subunit 1 / Dcp1-like decapping family / mRNA decapping protein 2, Box A domain / mRNA decapping protein 2, Box A domain superfamily / mRNA decapping enzyme 2 , NUDIX hydrolase domain / Dcp2, box A domain / Dcp2, box A domain / NUDIX hydrolase, conserved site / Nudix box signature. / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / NUDIX domain / PH-domain like / Nudix hydrolase domain profile. / NUDIX hydrolase domain / NUDIX hydrolase-like domain superfamily / PH-like domain superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 Chem-6VQ / mRNA decapping complex subunit 2 / Proline-rich nuclear receptor coactivator 2 / mRNA-decapping enzyme subunit 1類似検索 - 構成要素 |
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生物種 | Schizosaccharomyces pombe (分裂酵母) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.56 Å |
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データ登録者 | Mugridge, J.S. / Ziemniak, M. / Jemielity, J. / Gross, J.D. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM078360 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM105313 | 米国 |
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引用 | ジャーナル: Nat.Struct.Mol.Biol. / 年: 2016 タイトル: Structural basis of mRNA-cap recognition by Dcp1-Dcp2. 著者: Mugridge, J.S. / Ziemniak, M. / Jemielity, J. / Gross, J.D. |
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履歴 | 登録 | 2016年7月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年10月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年10月19日 | Group: Database references |
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改定 1.2 | 2016年11月16日 | Group: Database references |
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改定 1.3 | 2017年9月20日 | Group: Author supporting evidence / Derived calculations / カテゴリ: pdbx_audit_support / pdbx_struct_oper_list Item: _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.4 | 2017年11月1日 | Group: Author supporting evidence / カテゴリ: pdbx_struct_assembly_auth_evidence |
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改定 1.5 | 2019年12月25日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.6 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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Remark 650 | HELIX DETERMINATION METHOD: AUTHOR DETERMINED |
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Remark 700 | SHEET DETERMINATION METHOD: AUTHOR DETERMINED |
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