登録情報 | データベース: PDB / ID: 4tnd |
---|
タイトル | Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with AMP-PNP |
---|
要素 | G protein-coupled receptor kinase 5 |
---|
キーワード | SIGNALING PROTEIN / GRK5-(5-Adenylylimidodiphosphate) complex / GRK5-(AMP-PNP) complex / GPCR Kinase / Kinase / GPCR Kinase 5 |
---|
機能・相同性 | 機能・相同性情報
G-protein-coupled receptor kinase / beta-adrenergic receptor kinase activity / G protein-coupled receptor kinase activity / tachykinin receptor signaling pathway / regulation of G protein-coupled receptor signaling pathway / fat cell differentiation / regulation of signal transduction / protein kinase C binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / phospholipid binding ...G-protein-coupled receptor kinase / beta-adrenergic receptor kinase activity / G protein-coupled receptor kinase activity / tachykinin receptor signaling pathway / regulation of G protein-coupled receptor signaling pathway / fat cell differentiation / regulation of signal transduction / protein kinase C binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / phospholipid binding / Wnt signaling pathway / nuclear membrane / G alpha (s) signalling events / G alpha (q) signalling events / protein autophosphorylation / regulation of cell cycle / protein kinase activity / nuclear speck / G protein-coupled receptor signaling pathway / protein serine/threonine kinase activity / positive regulation of cell population proliferation / negative regulation of apoptotic process / apoptotic process / ATP binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 GPCR kinase / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / Extension to Ser/Thr-type protein kinases ...GPCR kinase / Regulator of G-protein Signalling 4, domain 2 / Regulator of G-protein Signalling 4; domain 2 / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / G protein-coupled receptor kinase 5類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.802 Å |
---|
データ登録者 | Bhardwaj, A. / Komolov, K.E. / Benovic, J.L. |
---|
引用 | ジャーナル: J.Biol.Chem. / 年: 2015 タイトル: Atomic Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) Reveals Distinct Structural Features Novel for GRKs. 著者: Komolov, K.E. / Bhardwaj, A. / Benovic, J.L. |
---|
履歴 | 登録 | 2014年6月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2015年6月10日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2015年6月17日 | Group: Database references |
---|
改定 1.2 | 2016年7月20日 | Group: Data collection |
---|
改定 1.3 | 2017年11月22日 | Group: Derived calculations / Refinement description / カテゴリ: pdbx_struct_oper_list / software Item: _pdbx_struct_oper_list.symmetry_operation / _software.classification |
---|
改定 1.4 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|