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TitleAtomic Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) Reveals Distinct Structural Features Novel for GRKs.
Journal, issue, pagesJ. Biol. Chem., Year 2015
Publish dateJun 3, 2014 (structure data deposition date)
AuthorsKomolov, K.E. / Bhardwaj, A. / Benovic, J.L.
External linksJ. Biol. Chem. / PubMed:26032409
MethodsX-ray diffraction
Resolution1.802 - 2.113 Å
Structure data

PDB-4tnb:
Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with Sangivamycin
Method: X-RAY DIFFRACTION / Resolution: 2.113 Å

PDB-4tnd:
Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with AMP-PNP
Method: X-RAY DIFFRACTION / Resolution: 1.802 Å

Chemicals

ChemComp-SGV:
SANGIVAMYCIN / inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / GRK5-Sangivamycin complex / GPCR Kinase / Kinase / inhibitor / GRK5-(5-Adenylylimidodiphosphate) complex / GRK5-(AMP-PNP) complex / GPCR Kinase 5

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