登録情報 | データベース: PDB / ID: 3bun |
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タイトル | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 |
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要素 | - 13-meric peptide from Protein sprouty homolog 4
- E3 ubiquitin-protein ligase CBL
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キーワード | LIGASE/SIGNALING PROTEIN / Cbl / TKB / ligase (リガーゼ) / signal transduction (シグナル伝達) / proto-oncogene (がん遺伝子) / complex / Alternative splicing (選択的スプライシング) / Cytoplasm (細胞質) / Developmental protein (ヒトの発達) / Membrane (生体膜) / Calcium (カルシウム) / Metal-binding / Phosphoprotein / SH2 domain (SH2ドメイン) / Ubl conjugation pathway / Zinc (亜鉛) / Zinc-finger (ジンクフィンガー) / LIGASE-SIGNALING PROTEIN COMPLEX |
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機能・相同性 | 機能・相同性情報
regulation of platelet-derived growth factor receptor-alpha signaling pathway / ubiquitin-dependent endocytosis / animal organ development / negative regulation of fibroblast growth factor receptor signaling pathway / regulation of Rap protein signal transduction / entry of bacterium into host cell / flotillin complex / phosphatidylinositol 3-kinase regulatory subunit binding / negative regulation of Ras protein signal transduction / positive regulation of epidermal growth factor receptor signaling pathway ...regulation of platelet-derived growth factor receptor-alpha signaling pathway / ubiquitin-dependent endocytosis / animal organ development / negative regulation of fibroblast growth factor receptor signaling pathway / regulation of Rap protein signal transduction / entry of bacterium into host cell / flotillin complex / phosphatidylinositol 3-kinase regulatory subunit binding / negative regulation of Ras protein signal transduction / positive regulation of epidermal growth factor receptor signaling pathway / Regulation of KIT signaling / mast cell degranulation / response to testosterone / Interleukin-6 signaling / negative regulation of epidermal growth factor receptor signaling pathway / response to starvation / cellular response to platelet-derived growth factor stimulus / protein monoubiquitination / TGF-beta receptor signaling activates SMADs / protein autoubiquitination / FLT3 signaling by CBL mutants / PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 / Negative regulation of FLT3 / phosphotyrosine residue binding / ephrin receptor binding / cellular response to nerve growth factor stimulus / negative regulation of MAP kinase activity / InlB-mediated entry of Listeria monocytogenes into host cell / response to activity / Regulation of signaling by CBL / Negative regulation of FGFR3 signaling / response to gamma radiation / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / EGFR downregulation / Negative regulation of FGFR1 signaling / Spry regulation of FGF signaling / RING-type E3 ubiquitin transferase / Constitutive Signaling by EGFRvIII / 繊毛 / Negative regulation of MET activity / negative regulation of ERK1 and ERK2 cascade / receptor tyrosine kinase binding / ruffle membrane / SH3 domain binding / protein polyubiquitination / positive regulation of receptor-mediated endocytosis / cytokine-mediated signaling pathway / ubiquitin-protein transferase activity / male gonad development / Signaling by CSF1 (M-CSF) in myeloid cells / ubiquitin protein ligase activity / Cargo recognition for clathrin-mediated endocytosis / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / Clathrin-mediated endocytosis / 成長円錐 / ubiquitin-dependent protein catabolic process / cellular response to hypoxia / response to ethanol / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / protein ubiquitination / cadherin binding / 脂質ラフト / focal adhesion / DNA damage response / calcium ion binding / negative regulation of apoptotic process / perinuclear region of cytoplasm / ゴルジ体 / シグナル伝達 / 細胞膜 / 細胞質基質類似検索 - 分子機能 Protein sprouty homologue 4 / Sprouty / Sprouty protein (Spry) / Sprouty (SPR) domain profile. / Adaptor protein Cbl, N-terminal domain / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain / Adaptor protein Cbl, PTB domain / Adaptor protein Cbl ...Protein sprouty homologue 4 / Sprouty / Sprouty protein (Spry) / Sprouty (SPR) domain profile. / Adaptor protein Cbl, N-terminal domain / Adaptor protein Cbl, N-terminal helical / Adaptor protein Cbl, EF hand-like / Adaptor protein Cbl, SH2-like domain / Adaptor protein Cbl, PTB domain / Adaptor protein Cbl / CBL proto-oncogene N-terminal domain 1 / CBL proto-oncogene N-terminus, EF hand-like domain / CBL proto-oncogene N-terminus, SH2-like domain / Cbl-type phosphotyrosine-binding (Cbl-PTB) domain profile. / Adaptor protein Cbl, N-terminal domain superfamily / Transcription Elongation Factor S-II; Chain A / UBA/TS-N domain / Ubiquitin associated domain / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / UBA-like superfamily / SH2ドメイン / SHC Adaptor Protein / EFハンド / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Recoverin; domain 1 / 薬指 / Zinc finger RING-type profile. / Zinc finger, RING-type / SH2 domain superfamily / EF-hand domain pair / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 E3 ubiquitin-protein ligase CBL / Protein sprouty homolog 4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
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データ登録者 | Ng, C. / Jackson, R.A. / Buschdorf, J.P. / Sun, Q. / Guy, G.R. / Sivaraman, J. |
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引用 | ジャーナル: Embo J. / 年: 2008 タイトル: Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates 著者: Ng, C. / Jackson, R.A. / Buschdorf, J.P. / Sun, Q. / Guy, G.R. / Sivaraman, J. |
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履歴 | 登録 | 2008年1月3日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2008年2月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software |
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改定 1.3 | 2020年9月16日 | Group: Database references / Derived calculations ...Database references / Derived calculations / Source and taxonomy / Structure summary カテゴリ: entity / pdbx_entity_src_syn ...entity / pdbx_entity_src_syn / struct / struct_conn / struct_ref_seq_dif Item: _entity.pdbx_description / _pdbx_entity_src_syn.details ..._entity.pdbx_description / _pdbx_entity_src_syn.details / _pdbx_entity_src_syn.ncbi_taxonomy_id / _pdbx_entity_src_syn.organism_common_name / _pdbx_entity_src_syn.organism_scientific / _struct.pdbx_descriptor / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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改定 1.4 | 2023年11月1日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.5 | 2023年11月15日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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