登録情報 データベース : PDB / ID : 1ywn 構造の表示 ダウンロードとリンクタイトル Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine 要素Vascular endothelial growth factor receptor 2 血管内皮細胞増殖因子受容体 詳細 キーワード TRANSFERASE (転移酵素)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
blood vessel endothelial cell differentiation / cellular response to hydrogen sulfide / regulation of bone development / Signaling by membrane-tethered fusions of PDGFRA or PDGFRB / regulation of hematopoietic progenitor cell differentiation / endothelium development / Neurophilin interactions with VEGF and VEGFR / vascular endothelial growth factor binding / positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway / vascular endothelial growth factor receptor-2 signaling pathway ... blood vessel endothelial cell differentiation / cellular response to hydrogen sulfide / regulation of bone development / Signaling by membrane-tethered fusions of PDGFRA or PDGFRB / regulation of hematopoietic progenitor cell differentiation / endothelium development / Neurophilin interactions with VEGF and VEGFR / vascular endothelial growth factor binding / positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway / vascular endothelial growth factor receptor-2 signaling pathway / VEGF binds to VEGFR leading to receptor dimerization / endocardium development / vascular wound healing / vascular endothelial growth factor receptor activity / post-embryonic camera-type eye morphogenesis / endothelial cell differentiation / mesenchymal cell proliferation / positive regulation of vasculogenesis / lymph vessel development / positive regulation of BMP signaling pathway / surfactant homeostasis / epithelial cell maturation / cell migration involved in sprouting angiogenesis / anchoring junction / positive regulation of positive chemotaxis / vascular endothelial growth factor signaling pathway / embryonic hemopoiesis / positive regulation of mesenchymal cell proliferation / positive regulation of mitochondrial fission / positive regulation of mitochondrial depolarization / branching involved in blood vessel morphogenesis / positive regulation of cell migration involved in sprouting angiogenesis / lung alveolus development / positive regulation of stem cell proliferation / positive regulation of nitric-oxide synthase biosynthetic process / growth factor binding / sorting endosome / positive regulation of focal adhesion assembly / regulation of MAPK cascade / semaphorin-plexin signaling pathway / positive regulation of macroautophagy / : / positive regulation of blood vessel endothelial cell migration / cellular response to vascular endothelial growth factor stimulus / calcium ion homeostasis / 細胞分化 / 脈管形成 / Integrin cell surface interactions / vascular endothelial growth factor receptor signaling pathway / coreceptor activity / negative regulation of endothelial cell apoptotic process / peptidyl-tyrosine autophosphorylation / ovarian follicle development / positive regulation of endothelial cell proliferation / transmembrane receptor protein tyrosine kinase activity / positive regulation of endothelial cell migration / VEGFR2 mediated cell proliferation / epithelial cell proliferation / stem cell proliferation / Hsp90 protein binding / 受容体型チロシンキナーゼ / VEGFA-VEGFR2 Pathway / peptidyl-tyrosine phosphorylation / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of angiogenesis / 遊走 / integrin binding / 細胞結合 / regulation of cell shape / protein tyrosine kinase activity / 血管新生 / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / receptor complex / エンドソーム / エンドソーム / positive regulation of cell migration / cadherin binding / positive regulation of protein phosphorylation / 脂質ラフト / external side of plasma membrane / negative regulation of gene expression / positive regulation of cell population proliferation / negative regulation of apoptotic process / ゴルジ体 / 小胞体 / extracellular region / ATP binding / identical protein binding / 細胞核 / 細胞膜 類似検索 - 分子機能 Vascular endothelial growth factor receptor 2 (VEGFR2) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / 免疫グロブリンフォールド / 抗体 / 免疫グロブリンフォールド / Immunoglobulin I-set ... Vascular endothelial growth factor receptor 2 (VEGFR2) / VEGFR-2, transmembrane domain / VEGFR-2 Transmembrane domain / Vascular endothelial growth factor receptor 1-like, Ig-like domain / Tyrosine-protein kinase, receptor class III, conserved site / Receptor tyrosine kinase class III signature. / 免疫グロブリンフォールド / 抗体 / 免疫グロブリンフォールド / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / 抗体 / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-LIF / Vascular endothelial growth factor receptor 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.71 Å 詳細データ登録者 Miyazaki, Y. / Matsunaga, S. / Tang, J. / Maeda, Y. / Nakano, M. / Philippe, R.J. / Shibahara, M. / Liu, W. / Sato, H. / Wang, L. / Nolte, R.T. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2005タイトル : Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors
著者 :
Miyazaki, Y. / Matsunaga, S. / Tang, J. / Maeda, Y. / Nakano, M. / Philippe, R.J. / Shibahara, M. / Liu, W. / Sato, H. / Wang, L. / Nolte, R.T. 残り1件を表示 表示を減らす#1: ジャーナル : Structure / 年 : 1999タイトル : Crystal Structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis
履歴 登録 2005年2月18日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2005年8月23日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月30日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Advisory / Version format compliance改定 1.3 2017年10月11日 Group : Refinement description / カテゴリ : software / Item : _software.classification / _software.name改定 1.4 2021年10月20日 Group : Database references / Derived calculationsカテゴリ : database_2 / struct_conn ... database_2 / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.5 2023年8月23日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model改定 1.6 2023年11月15日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
すべて表示 表示を減らす Remark 999 SEQUENCE Deletion of residues 938-987 (corresponds to dbref 940-989)