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TitleNovel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 15, Page 2203-2207, Year 2005
Publish dateFeb 18, 2005 (structure data deposition date)
AuthorsMiyazaki, Y. / Matsunaga, S. / Tang, J. / Maeda, Y. / Nakano, M. / Philippe, R.J. / Shibahara, M. / Liu, W. / Sato, H. / Wang, L. / Nolte, R.T.
External linksBioorg. Med. Chem. Lett. / PubMed:15837294
MethodsX-ray diffraction
Resolution1.71 Å
Structure data

PDB-1ywn:
Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine
Method: X-RAY DIFFRACTION / Resolution: 1.71 Å

Chemicals

ChemComp-LIF:
N-{4-[4-AMINO-6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-5-YL]PHENYL}-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE

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