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- SASDEF6: Epstein-Barr nuclear antigen 2 (EBNA2 Type1, amino acids 381-455) -

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Open data


ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDEF6
SampleEpstein-Barr nuclear antigen 2 (EBNA2 Type1, amino acids 381-455)
  • Epstein-Barr nuclear antigen 2 (protein), EBNA2 Type1, Epstein-Barr virus (strain B95-8)
Function / homology
Function and homology information


host cell nuclear matrix / protein serine/threonine phosphatase inhibitor activity / DNA-templated viral transcription / symbiont-mediated perturbation of host transcription / symbiont-mediated perturbation of host cell cycle progression / symbiont-mediated suppression of host translation initiation / symbiont-mediated suppression of host innate immune response / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / positive regulation of DNA-templated transcription / host cell nucleus
Similarity search - Function
Epstein-Barr nuclear antigen 2
Similarity search - Component
Biological speciesEpstein-Barr virus (strain B95-8) (Epstein-Barr virus (strain B95-8))
CitationDate: 2018 Nov 6
Title: Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts B cell growth
Authors: Ponnusamy R / Khatri R / Correia P / Mancini E / Farrell P
Contact author
  • Rajesh Ponnusamy (University of Sussex, Brighton, UK)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #2534
Type: dummy / Radius of dummy atoms: 2.25 A / Chi-square value: 1.590 / P-value: 0.128072
Search similar-shape structures of this assembly by Omokage search (details)
Model #2545
Type: dummy / Radius of dummy atoms: 2.25 A / Chi-square value: 1.590 / P-value: 0.128072
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Epstein-Barr nuclear antigen 2 (EBNA2 Type1, amino acids 381-455)
Specimen concentration: 5.4 mg/ml
BufferName: 20mM Tris-HCl, 100mM NaCl, 2% Sucrose and 1mM TCEP / pH: 7.5
Entity #1341Name: EBNA2 Type1 / Type: protein / Description: Epstein-Barr nuclear antigen 2 / Formula weight: 7.831 / Num. of mol.: 2 / Source: Epstein-Barr virus (strain B95-8) / References: UniProt: P12978
Sequence:
SMPELSPVLG LHQGQGAGDS PTPGPSNAAP VCRNSHTATP NVSPIHEPES HNSPEAPILF PDDWYPPSID PADLD

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Experimental information

BeamInstrument name: Diamond Light Source B21 / City: Didcot / 国: UK / Shape: 1 x 5 mm / Type of source: X-ray synchrotron / Wavelength: 0.1 Å / Dist. spec. to detc.: 4.014 mm
DetectorName: Pilatus 2M
Scan
Title: Epstein-Barr nuclear antigen 2 (EBNA2 Type1, amino acids 381-455)
Measurement date: Sep 23, 2017 / Storage temperature: 4 °C / Cell temperature: 25 °C / Exposure time: 3 sec. / Number of frames: 18 / Unit: 1/A /
MinMax
Q0.0341 0.3499
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 1120 /
MinMax
Q0.0340534 0.291151
P(R) point1 1120
R0 93.08
Result
Type of curve: sec
Comments: SEC-SAXS was performed using the following parameters: Column type: S200 3.2/300 increase; Flow rate: 0.075 ml/min; Injection volume: 45 µl; Sample injection concentration: 5.4 mg/ml.
ExperimentalPorod
MW14.4 kDa-
Volume-18.5 nm3

P(R)GuinierGuinier error
Forward scattering, I00.02142 0.021 5.65E-5
Radius of gyration, Rg2.84 nm2.7 nm0.44

MinMax
D-9.31
Guinier point1 59

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