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- SASDEG6: Epstein-Barr nuclear antigen 2 (EBNA2 Type2, amino acids 348-422) -

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Open data


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Basic information

Entry
Database: SASBDB / ID: SASDEG6
SampleEpstein-Barr nuclear antigen 2 (EBNA2 Type2, amino acids 348-422)
  • Epstein-Barr nuclear antigen 2 (protein), EBNA2 Type2, Epstein-Barr virus (strain AG876)
Function / homologysymbiont-mediated perturbation of host cell cycle progression / host cell nuclear matrix / protein serine/threonine phosphatase inhibitor activity / symbiont-mediated suppression of host translation initiation / symbiont-mediated suppression of host innate immune response / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / virus-mediated perturbation of host defense response / Epstein-Barr nuclear antigen 2
Function and homology information
Biological speciesEpstein-Barr virus (strain AG876)
CitationDate: 2018 Nov 6
Title: Increased association between Epstein-Barr virus EBNA2 from type 2 strains and the transcriptional repressor BS69 restricts B cell growth
Authors: Ponnusamy R / Khatri R / Correia P / Mancini E / Farrell P
Contact author
  • Rajesh Ponnusamy (University of Sussex, Brighton, UK)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #2537
Type: dummy / Radius of dummy atoms: 2.50 A / Chi-square value: 1.783 / P-value: 0.591803
Search similar-shape structures of this assembly by Omokage search (details)
Model #2547
Type: dummy / Radius of dummy atoms: 2.50 A / Chi-square value: 1.783 / P-value: 0.591803
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Epstein-Barr nuclear antigen 2 (EBNA2 Type2, amino acids 348-422)
Specimen concentration: 4.6 mg/ml
BufferName: 20mM Tris-HCl, 100mM NaCl, 2% Sucrose and 1mM TCEP / pH: 7.5
Entity #1342Name: EBNA2 Type2 / Type: protein / Description: Epstein-Barr nuclear antigen 2 / Formula weight: 7.934 / Num. of mol.: 2 / Source: Epstein-Barr virus (strain AG876) / References: UniProt: Q69022
Sequence:
SMPQLSPVVS LHQGQGPENS PTPGPSTAGP VCRVTPSATP DISPIHEPES SDSEEPPFLF PSDWYPPTLE PAELD

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Experimental information

BeamInstrument name: Diamond Light Source B21 / City: Didcot / 国: UK / Shape: 1 x 5 mm / Type of source: X-ray synchrotron / Wavelength: 0.1 Å / Dist. spec. to detc.: 4.014 mm
DetectorName: Pilatus 2M
Scan
Title: Epstein-Barr nuclear antigen 2 (EBNA2 Type2, amino acids 348-422)
Measurement date: Sep 23, 2017 / Storage temperature: 4 °C / Cell temperature: 25 °C / Exposure time: 3 sec. / Number of frames: 100 / Unit: 1/A /
MinMax
Q0.0341 0.2442
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 917 /
MinMax
Q0.0340534 0.244221
P(R) point1 917
R0 103.5
Result
Type of curve: sec
Comments: SEC-SAXS was performed using the following parameters: Column type: S200 3.2/300 increase; Flow rate: 0.075 ml/min; Injection volume: 45 µl; Sample injection concentration: 4.6 mg/ml.
ExperimentalPorod
MW18.1 kDa-
Volume-20 nm3

P(R)GuinierGuinier error
Forward scattering, I00.02772 0.026812 7.111E-5
Radius of gyration, Rg3.01 nm2.77 nm0.09

MinMax
D-10.35
Guinier point1 59

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