登録情報 | データベース: PDB / ID: 7rkf |
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タイトル | Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state |
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要素 | - (Guanine nucleotide-binding protein ...) x 3
- Antibody fragment scFv16
- Fractalkine
- G-protein coupled receptor homolog US28
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キーワード | MEMBRANE PROTEIN / Viral GPCR / HCMV / cytomegalovirus / G protein complex / GDP-bound state |
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機能・相同性 | 機能・相同性情報
positive regulation by virus of host cell division / CXCR1 chemokine receptor binding / positive regulation of calcium-independent cell-cell adhesion / negative regulation of glutamate receptor signaling pathway / negative regulation of interleukin-1 alpha production / leukocyte adhesive activation / regulation of melanocyte differentiation / CX3C chemokine receptor binding / negative regulation of hippocampal neuron apoptotic process / autocrine signaling ...positive regulation by virus of host cell division / CXCR1 chemokine receptor binding / positive regulation of calcium-independent cell-cell adhesion / negative regulation of glutamate receptor signaling pathway / negative regulation of interleukin-1 alpha production / leukocyte adhesive activation / regulation of melanocyte differentiation / CX3C chemokine receptor binding / negative regulation of hippocampal neuron apoptotic process / autocrine signaling / synapse pruning / negative regulation of neuron migration / positive regulation of microglial cell migration / negative regulation of microglial cell activation / regulation of lipopolysaccharide-mediated signaling pathway / Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion / Acetylcholine regulates insulin secretion / endothelin receptor signaling pathway / ion channel modulating, G protein-coupled receptor signaling pathway / positive regulation of transforming growth factor beta1 production / phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway / developmental pigmentation / positive regulation of I-kappaB phosphorylation / cellular response to pH / microglial cell proliferation / PLC beta mediated events / phospholipase C-activating dopamine receptor signaling pathway / CCR chemokine receptor binding / cranial skeletal system development / positive regulation of actin filament bundle assembly / lymphocyte chemotaxis / leukocyte migration involved in inflammatory response / phototransduction, visible light / C-C chemokine receptor activity / entrainment of circadian clock / integrin activation / C-C chemokine binding / angiogenesis involved in wound healing / eosinophil chemotaxis / chemokine-mediated signaling pathway / leukocyte chemotaxis / Chemokine receptors bind chemokines / chemokine activity / negative regulation of cell-substrate adhesion / negative regulation of interleukin-1 beta production / positive regulation of cell-matrix adhesion / action potential / neuron remodeling / positive regulation of neuroblast proliferation / positive chemotaxis / chemoattractant activity / ligand-gated ion channel signaling pathway / monocyte chemotaxis / negative regulation of interleukin-6 production / negative regulation of apoptotic signaling pathway / negative regulation of tumor necrosis factor production / regulation of neurogenesis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / photoreceptor outer segment / cellular response to interleukin-1 / enzyme regulator activity / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of cell migration / neutrophil chemotaxis / cell chemotaxis / positive regulation of release of sequestered calcium ion into cytosol / G protein activity / skeletal system development / cell projection / response to ischemia / G protein-coupled receptor binding / calcium-mediated signaling / positive regulation of smooth muscle cell proliferation / microglial cell activation / G-protein beta/gamma-subunit complex binding / Olfactory Signaling Pathway / regulation of synaptic plasticity / Activation of the phototransduction cascade / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / G beta:gamma signalling through PLC beta / Presynaptic function of Kainate receptors / Thromboxane signalling through TP receptor / G-protein activation / positive regulation of insulin secretion / G protein-coupled acetylcholine receptor signaling pathway / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Prostacyclin signalling through prostacyclin receptor / Glucagon signaling in metabolic regulation / G beta:gamma signalling through CDC42 / ADP signalling through P2Y purinoceptor 12 / G beta:gamma signalling through BTK / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Sensory perception of sweet, bitter, and umami (glutamate) taste / defense response / cytokine-mediated signaling pathway / photoreceptor disc membrane / regulation of blood pressure / Adrenaline,noradrenaline inhibits insulin secretion / Glucagon-type ligand receptors類似検索 - 分子機能 CX3C chemokine domain / G-protein alpha subunit, group Q / Chemokine receptor family / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit ...CX3C chemokine domain / G-protein alpha subunit, group Q / Chemokine receptor family / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein subunit alpha-11 / Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 / Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 / G-protein coupled receptor homolog US28 / Fractalkine類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
![](img/tx_virus.gif) Human cytomegalovirus (ヘルペスウイルス) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 4 Å |
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データ登録者 | Tsutsumi, N. / Maeda, S. / Qu, Q. / Skiniotis, G. / Kobilka, B.K. / Garcia, K.C. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01AI125320 | 米国 | Howard Hughes Medical Institute (HHMI) | | 米国 |
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引用 | ジャーナル: Sci Adv / 年: 2022 タイトル: Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins 著者: Tsutsumi, N. / Maeda, S. / Qu, Q. / Voegele, M. / Jude, K.M. / Suomivuori, C.M. / Panova, O. / Waghray, D. / Kato, H.E. / Velasco, A. / Dror, R.O. / Skiniotis, G. / Kobilka, B.K. / Garcia, K.C. |
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履歴 | 登録 | 2021年7月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年1月26日 | Provider: repository / タイプ: Initial release |
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