- PDB-7o3b: Crystal structure of the TTBK2-CEP164 complex bound to a camelid ... -
+
データを開く
IDまたはキーワード:
読み込み中...
-
基本情報
登録情報
データベース: PDB / ID: 7o3b
タイトル
Crystal structure of the TTBK2-CEP164 complex bound to a camelid nanobody
要素
Nanobody 36Z
Tau-tubulin kinase 2,Centrosomal protein of 164 kDa
キーワード
STRUCTURAL PROTEIN / Centriole / Centrosome / Basal body / Ciliogenesis
機能・相同性
機能・相同性情報
ciliary transition fiber / negative regulation of microtubule binding / negative regulation of protein localization to microtubule / cerebellar granular layer development / cerebellar granule cell precursor tangential migration / ciliary transition zone / negative regulation of microtubule depolymerization / microtubule plus-end binding / smoothened signaling pathway / tau-protein kinase activity ...ciliary transition fiber / negative regulation of microtubule binding / negative regulation of protein localization to microtubule / cerebellar granular layer development / cerebellar granule cell precursor tangential migration / ciliary transition zone / negative regulation of microtubule depolymerization / microtubule plus-end binding / smoothened signaling pathway / tau-protein kinase activity / kinesin binding / cilium assembly / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / regulation of cell migration / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / centriole / AURKA Activation by TPX2 / cerebellum development / ciliary basal body / tau protein binding / microtubule cytoskeleton organization / Regulation of PLK1 Activity at G2/M Transition / peptidyl-serine phosphorylation / non-specific serine/threonine protein kinase / protein kinase activity / cell cycle / cell division / intracellular membrane-bounded organelle / DNA repair / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / signal transduction / extracellular space / nucleoplasm / ATP binding / nucleus / cytosol 類似検索 - 分子機能
: / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. ...: / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / WW domain / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
Tau-tubulin kinase 2 / Centrosomal protein of 164 kDa 類似検索 - 構成要素
A: Nanobody 36Z G: Tau-tubulin kinase 2,Centrosomal protein of 164 kDa
登録者が定義した集合体
根拠: isothermal titration calorimetry, CEP164 (1-104) interaction with the proline-rich TTBK2 peptide (1074-1087) (chain G) through its WW domain was confirmed by ITC. CEP164(1-104) interaction ...根拠: isothermal titration calorimetry, CEP164 (1-104) interaction with the proline-rich TTBK2 peptide (1074-1087) (chain G) through its WW domain was confirmed by ITC. CEP164(1-104) interaction with the nanobody 36Z was not confirmed experimentally. However, the nanobody interacts with CEP164 N-terminal region through its CDR3 loop, as expected.
B: Nanobody 36Z H: Tau-tubulin kinase 2,Centrosomal protein of 164 kDa
登録者が定義した集合体
根拠: isothermal titration calorimetry, CEP164 (1-104) interaction with the proline-rich TTBK2 peptide (1074-1087) (chain G) through its WW domain was confirmed by ITC. CEP164(1-104) interaction ...根拠: isothermal titration calorimetry, CEP164 (1-104) interaction with the proline-rich TTBK2 peptide (1074-1087) (chain G) through its WW domain was confirmed by ITC. CEP164(1-104) interaction with the nanobody 36Z was not confirmed experimentally. However, the nanobody interacts with CEP164 N-terminal region through its CDR3 loop, as expected.
C: Nanobody 36Z I: Tau-tubulin kinase 2,Centrosomal protein of 164 kDa
登録者が定義した集合体
根拠: isothermal titration calorimetry, CEP164 (1-104) interaction with the proline-rich TTBK2 peptide (1074-1087) (chain G) through its WW domain was confirmed by ITC. CEP164(1-104) interaction ...根拠: isothermal titration calorimetry, CEP164 (1-104) interaction with the proline-rich TTBK2 peptide (1074-1087) (chain G) through its WW domain was confirmed by ITC. CEP164(1-104) interaction with the nanobody 36Z was not confirmed experimentally. However, the nanobody interacts with CEP164 N-terminal region through its CDR3 loop, as expected.