Entry | Database: PDB / ID: 7ler |
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Title | Netrin-1 filament assembly |
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Components | Netrin-1 |
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Keywords | SIGNALING PROTEIN / heparin binding protein / filament |
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Function / homology | Function and homology information
regulation of glial cell migration / chemorepulsion of axon / anterior/posterior axon guidance / B cell mediated immunity / Cdc42 protein signal transduction / motor neuron migration / tissue development / negative regulation of axon extension / T cell mediated immunity / substrate-dependent cell migration, cell extension ...regulation of glial cell migration / chemorepulsion of axon / anterior/posterior axon guidance / B cell mediated immunity / Cdc42 protein signal transduction / motor neuron migration / tissue development / negative regulation of axon extension / T cell mediated immunity / substrate-dependent cell migration, cell extension / motor neuron axon guidance / positive regulation of cell motility / nuclear migration / regulation of synapse assembly / inner ear morphogenesis / B cell proliferation / dendrite development / basement membrane / glial cell proliferation / positive regulation of axon extension / positive regulation of glial cell proliferation / substrate adhesion-dependent cell spreading / cytokine activity / cell periphery / animal organ morphogenesis / cell-cell adhesion / actin cytoskeleton / Ras protein signal transduction / extracellular region / nucleoplasm / cytosolSimilarity search - Function Laminin, N-terminal / Laminin N-terminal (Domain VI) / Laminin N-terminal domain profile. / Laminin N-terminal domain (domain VI) / Laminin-type EGF-like (LE) domain profile. / Laminin-type EGF-like (LE) domain signature. / Laminin-type epidermal growth factor-like domai / Laminin EGF domain / Laminin-type EGF domain / Netrin C-terminal Domain ...Laminin, N-terminal / Laminin N-terminal (Domain VI) / Laminin N-terminal domain profile. / Laminin N-terminal domain (domain VI) / Laminin-type EGF-like (LE) domain profile. / Laminin-type EGF-like (LE) domain signature. / Laminin-type epidermal growth factor-like domai / Laminin EGF domain / Laminin-type EGF domain / Netrin C-terminal Domain / Netrin module, non-TIMP type / UNC-6/NTR/C345C module / Netrin domain / NTR domain profile. / Tissue inhibitor of metalloproteinases-like, OB-fold / EGF-like domain signature 1. / Galactose-binding-like domain superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_bird.gif) Gallus gallus (chicken) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 5.99 Å |
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Authors | McDougall, M. / Gupta, M. / Stetefeld, J. |
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Funding support | Canada, 1items Organization | Grant number | Country |
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Canadian Institutes of Health Research (CIHR) | RPA-109759 | Canada |
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Citation | Journal: Nat Commun / Year: 2023 Title: The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation. Authors: Meier, M. / Gupta, M. / Akgul, S. / McDougall, M. / Imhof, T. / Nikodemus, D. / Reuten, R. / Moya-Torres, A. / To, V. / Ferens, F. / Heide, F. / Padilla-Meier, G.P. / Kukura, P. / Huang, W. ...Authors: Meier, M. / Gupta, M. / Akgul, S. / McDougall, M. / Imhof, T. / Nikodemus, D. / Reuten, R. / Moya-Torres, A. / To, V. / Ferens, F. / Heide, F. / Padilla-Meier, G.P. / Kukura, P. / Huang, W. / Gerisch, B. / Morgelin, M. / Poole, K. / Antebi, A. / Koch, M. / Stetefeld, J. |
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History | Deposition | Jan 14, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Feb 23, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 15, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Aug 16, 2023 | Group: Data collection / Other Category: chem_comp_atom / chem_comp_bond / pdbx_database_status Item: _pdbx_database_status.pdb_format_compatible |
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Revision 1.3 | Oct 25, 2023 | Group: Refinement description / Category: pdbx_initial_refinement_model |
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