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Yorodumi- PDB-7k17: Re-refined crystal structure of DNA-dependent protein kinase cata... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7k17 | ||||||
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Title | Re-refined crystal structure of DNA-dependent protein kinase catalytic subunit complexed with Ku80 C-terminal helix | ||||||
Components |
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Keywords | DNA BINDING PROTEIN / NHEJ / V(D)J recombination / DNA repair | ||||||
Function / homology | Function and homology information Ku70:Ku80 complex / negative regulation of t-circle formation / DNA end binding / small-subunit processome assembly / DNA-dependent protein kinase complex / DNA-dependent protein kinase-DNA ligase 4 complex / cellular response to X-ray / nonhomologous end joining complex / nuclear telomere cap complex / regulation of smooth muscle cell proliferation ...Ku70:Ku80 complex / negative regulation of t-circle formation / DNA end binding / small-subunit processome assembly / DNA-dependent protein kinase complex / DNA-dependent protein kinase-DNA ligase 4 complex / cellular response to X-ray / nonhomologous end joining complex / nuclear telomere cap complex / regulation of smooth muscle cell proliferation / Cytosolic sensors of pathogen-associated DNA / IRF3-mediated induction of type I IFN / recombinational repair / regulation of telomere maintenance / U3 snoRNA binding / positive regulation of neurogenesis / protein localization to chromosome, telomeric region / cellular response to fatty acid / hematopoietic stem cell proliferation / cellular hyperosmotic salinity response / telomeric DNA binding / positive regulation of catalytic activity / 2-LTR circle formation / site of DNA damage / enzyme activator activity / hematopoietic stem cell differentiation / positive regulation of protein kinase activity / ATP-dependent activity, acting on DNA / positive regulation of telomerase activity / positive regulation of telomere maintenance via telomerase / DNA helicase activity / activation of innate immune response / telomere maintenance / cellular response to leukemia inhibitory factor / neurogenesis / small-subunit processome / protein-DNA complex / Nonhomologous End-Joining (NHEJ) / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / cellular response to gamma radiation / double-strand break repair via nonhomologous end joining / double-strand break repair / double-stranded DNA binding / secretory granule lumen / DNA recombination / damaged DNA binding / chromosome, telomeric region / transcription cis-regulatory region binding / response to xenobiotic stimulus / ribonucleoprotein complex / innate immune response / negative regulation of DNA-templated transcription / DNA damage response / ubiquitin protein ligase binding / Neutrophil degranulation / protein-containing complex binding / nucleolus / ATP hydrolysis activity / protein-containing complex / DNA binding / RNA binding / extracellular region / nucleoplasm / ATP binding / membrane / nucleus / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 4.3 Å | ||||||
Authors | Chen, X. / Gellert, M. / Yang, W. | ||||||
Funding support | United States, 1items
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Citation | Journal: Science / Year: 2017 Title: DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Authors: Sibanda, B.L. / Chirgadze, D.Y. / Ascher, D.B. / Blundell, T.L. | ||||||
History |
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Remark 0 | THIS ENTRY 7K17 REFLECTS AN ALTERNATIVE MODELING OF THE ORIGINAL DATA IN 5LUQ, DETERMINED BY B.L. ...THIS ENTRY 7K17 REFLECTS AN ALTERNATIVE MODELING OF THE ORIGINAL DATA IN 5LUQ, DETERMINED BY B.L.Sibanda, D.Y.Chirgadze, D.B.Ascher, T.L.Blundell |
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7k17.cif.gz | 3.1 MB | Display | PDBx/mmCIF format |
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PDB format | pdb7k17.ent.gz | 2.3 MB | Display | PDB format |
PDBx/mmJSON format | 7k17.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/k1/7k17 ftp://data.pdbj.org/pub/pdb/validation_reports/k1/7k17 | HTTPS FTP |
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-Related structure data
Related structure data | 7k0ySC 7k10C 7k11C 7k19C 7k1bC 7k1jC 7k1kC 7k1nC S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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