Entry Database : PDB / ID : 7jn5 Structure visualization Downloads & linksTitle Crystal structure of SARS-CoV receptor binding domain in complex with human antibody CR3022 ComponentsCR3022 heavy chain CR3022 light chain Spike glycoprotein DetailsKeywords Viral protein/IMMUNE SYSTEM / SARS / coronavirus / antibody / IMMUNE SYSTEM / Viral protein-IMMUNE SYSTEM complexFunction / homology Function and homology informationFunction Domain/homology Component
Maturation of spike protein / Translation of Structural Proteins / Virion Assembly and Release / : / Attachment and Entry / endocytosis involved in viral entry into host cell / SARS-CoV-1 activates/modulates innate immune responses / suppression by virus of host tetherin activity / membrane => GO:0016020 / host cell endoplasmic reticulum-Golgi intermediate compartment membrane ... Maturation of spike protein / Translation of Structural Proteins / Virion Assembly and Release / : / Attachment and Entry / endocytosis involved in viral entry into host cell / SARS-CoV-1 activates/modulates innate immune responses / suppression by virus of host tetherin activity / membrane => GO:0016020 / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / host cell plasma membrane / virion membrane / identical protein binding / membrane Similarity search - Function : / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding ... : / Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal Similarity search - Domain/homologyBiological species Homo sapiens (human) Human SARS coronavirusMethod X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.705 Å DetailsAuthors Wu, N.C. / Yuan, M. / Zhu, X. / Wilson, I.A. Funding support United States, 3items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) AI139445 United States Bill & Melinda Gates Foundation OPP1170236 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) UM1 AI44462 United States
CitationJournal : Plos Pathog. / Year : 2020Title : A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody.Authors : Wu, N.C. / Yuan, M. / Bangaru, S. / Huang, D. / Zhu, X. / Lee, C.D. / Turner, H.L. / Peng, L. / Yang, L. / Burton, D.R. / Nemazee, D. / Ward, A.B. / Wilson, I.A. History Deposition Aug 3, 2020 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 28, 2020 Provider : repository / Type : Initial releaseRevision 1.1 May 12, 2021 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Oct 18, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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