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- PDB-7jln: Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab -
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Open data
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Basic information
Entry | Database: PDB / ID: 7jln | ||||||
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Title | Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab | ||||||
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![]() | IMMUNE SYSTEM / iv9 / glVRC01 / Fab / HIV-1 / anti-idiotype | ||||||
Function / homology | AMMONIUM ION![]() | ||||||
Biological species | ![]() ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Weidle, C. / Pancera, M. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies. Authors: Seydoux, E. / Wan, Y.H. / Feng, J. / Wall, A. / Aljedani, S. / Homad, L.J. / MacCamy, A.J. / Weidle, C. / Gray, M.D. / Brumage, L. / Taylor, J.J. / Pancera, M. / Stamatatos, L. / McGuire, A.T. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 326.1 KB | Display | ![]() |
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PDB format | ![]() | 260.3 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 457.1 KB | Display | ![]() |
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Full document | ![]() | 459.4 KB | Display | |
Data in XML | ![]() | 32.7 KB | Display | |
Data in CIF | ![]() | 45.9 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 6vrqC ![]() 6xocC ![]() 7jlkC ![]() 6mftS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Unit cell |
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Components
-Antibody , 4 types, 4 molecules ABHL
#1: Antibody | Mass: 24209.043 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Antibody | Mass: 23969.477 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
#3: Antibody | Mass: 25302.238 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
#4: Antibody | Mass: 23019.514 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
-Non-polymers , 3 types, 242 molecules ![](data/chem/img/NH4.gif)
![](data/chem/img/NA.gif)
![](data/chem/img/HOH.gif)
![](data/chem/img/NA.gif)
![](data/chem/img/HOH.gif)
#5: Chemical | ChemComp-NH4 / #6: Chemical | ChemComp-NA / | #7: Water | ChemComp-HOH / | |
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-Details
Has ligand of interest | N |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.25 Å3/Da / Density % sol: 45.36 % |
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Crystal grow | Temperature: 293 K / Method: vapor diffusion, hanging drop Details: 0.08 M Sodium Acetate, 24% PEG 4000, 0.16 M Ammonium Acetate |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Mar 28, 2019 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1 Å / Relative weight: 1 |
Reflection | Resolution: 2.57→50 Å / Num. obs: 26793 / % possible obs: 99.8 % / Redundancy: 3.2 % / Biso Wilson estimate: 42.94 Å2 / CC1/2: 0.981 / Net I/σ(I): 7.92 |
Reflection shell | Resolution: 2.573→2.665 Å / Num. unique obs: 2057 / CC1/2: 0.676 |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: 6MFT Resolution: 2.57→47.72 Å / SU ML: 0.3869 / Cross valid method: FREE R-VALUE / σ(F): 1.35 / Phase error: 28.5844 Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 47.95 Å2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.57→47.72 Å
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Refine LS restraints |
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LS refinement shell |
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