Entry Database : PDB / ID : 6bpp Structure visualization Downloads & linksTitle E. coli MsbA in complex with LPS and inhibitor G092 ComponentsLipid A export ATP-binding/permease protein MsbA Details Keywords LIPID TRANSPORT / ABC transporter / inhibitor / LPS / MsbAFunction / homology Function and homology informationFunction Domain/homology Component
ABC-type lipid A-core oligosaccharide transporter / ATPase-coupled lipid transmembrane transporter activity / ABC-type transporter activity / ATP hydrolysis activity / ATP binding / identical protein binding / plasma membrane Similarity search - Function Lipid A export ATP-binding/permease protein msbA family profile. / ABC transporter, lipid A-core flippase, MsbA / Type 1 protein exporter / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter ... Lipid A export ATP-binding/permease protein msbA family profile. / ABC transporter, lipid A-core flippase, MsbA / Type 1 protein exporter / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain / ATP-binding cassette, ABC transporter-type domain profile. / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homology 1,2-Distearoyl-sn-glycerophosphoethanolamine / LAURIC ACID / Chem-E1M / 3-HYDROXY-TETRADECANOIC ACID / MYRISTIC ACID / PHOSPHATE ION / ATP-dependent lipid A-core flippase / ATP-dependent lipid A-core flippase Similarity search - ComponentBiological species Escherichia coli O6:H1 (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.92 Å DetailsAuthors Ho, H. / Koth, C.M. / Payandeh, J. CitationJournal : Nature / Year : 2018Title : Structural basis for dual-mode inhibition of the ABC transporter MsbA.Authors: Ho, H. / Miu, A. / Alexander, M.K. / Garcia, N.K. / Oh, A. / Zilberleyb, I. / Reichelt, M. / Austin, C.D. / Tam, C. / Shriver, S. / Hu, H. / Labadie, S.S. / Liang, J. / Wang, L. / Wang, J. / ... Authors : Ho, H. / Miu, A. / Alexander, M.K. / Garcia, N.K. / Oh, A. / Zilberleyb, I. / Reichelt, M. / Austin, C.D. / Tam, C. / Shriver, S. / Hu, H. / Labadie, S.S. / Liang, J. / Wang, L. / Wang, J. / Lu, Y. / Purkey, H.E. / Quinn, J. / Franke, Y. / Clark, K. / Beresini, M.H. / Tan, M.W. / Sellers, B.D. / Maurer, T. / Koehler, M.F.T. / Wecksler, A.T. / Kiefer, J.R. / Verma, V. / Xu, Y. / Nishiyama, M. / Payandeh, J. / Koth, C.M. History Deposition Nov 24, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 2, 2018 Provider : repository / Type : Initial releaseRevision 1.1 May 16, 2018 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.nameRevision 1.2 May 30, 2018 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.3 Sep 12, 2018 Group : Data collection / Database references / Source and taxonomyCategory : entity_src_gen / struct_ref ... entity_src_gen / struct_ref / struct_ref_seq / struct_ref_seq_dif Item : _entity_src_gen.gene_src_strain / _entity_src_gen.pdbx_gene_src_gene ... _entity_src_gen.gene_src_strain / _entity_src_gen.pdbx_gene_src_gene / _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id / _entity_src_gen.pdbx_gene_src_scientific_name / _struct_ref.db_code / _struct_ref.pdbx_db_accession / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq.pdbx_db_accession Revision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_unobs_or_zero_occ_atoms / pdbx_validate_close_contact / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_unobs_or_zero_occ_atoms.label_asym_id / _pdbx_validate_close_contact.auth_asym_id_1 / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_atom_id_1 / _pdbx_validate_close_contact.auth_atom_id_2 / _pdbx_validate_close_contact.auth_comp_id_1 / _pdbx_validate_close_contact.auth_comp_id_2 / _pdbx_validate_close_contact.auth_seq_id_1 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Mar 13, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / struct_conn Item : _chem_comp.name / _chem_comp.pdbx_synonyms ... _chem_comp.name / _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_leaving_atom_flag
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