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Structure paper

TitleDevelopment of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Journal, issue, pagesCell Rep, Vol. 35, Page 109084-109084, Year 2021
Publish dateFeb 8, 2020 (structure data deposition date)
AuthorsSeydoux, E. / Wan, Y.H. / Feng, J. / Wall, A. / Aljedani, S. / Homad, L.J. / MacCamy, A.J. / Weidle, C. / Gray, M.D. / Brumage, L. ...Seydoux, E. / Wan, Y.H. / Feng, J. / Wall, A. / Aljedani, S. / Homad, L.J. / MacCamy, A.J. / Weidle, C. / Gray, M.D. / Brumage, L. / Taylor, J.J. / Pancera, M. / Stamatatos, L. / McGuire, A.T.
External linksCell Rep / PubMed:33951425
MethodsX-ray diffraction
Resolution1.99 - 2.57 Å
Structure data

PDB-6vrq:
Crystal structure of gl12A21 Fab in complex with anti-idiotypic iv12 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

PDB-6xoc:
Crystal structure of glVRC01 Fab in complex with anti-idiotypic iv4 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-7jlk:
Crystal structure of glVRC01 Fab in complex with anti-idiotype iv1 scFv
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-7jln:
Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-K:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SCN:
THIOCYANATE ION

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-NA:
Unknown entry

ChemComp-NH4:
AMMONIUM ION

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab / Complex / gl12A21 / HIV / CD4-binding site / iv12 / iv1 / glVRC01 / scFv / HIV-1 / anti-idiotype / iv9

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