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Open data
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Basic information
Entry | Database: PDB / ID: 7.0E+58 | ||||||
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Title | interferon-inducible anti-viral protein 2 | ||||||
![]() | Guanylate-binding protein 2 | ||||||
![]() | HYDROLASE / interferon-induced / GTPase / anti-HIV | ||||||
Function / homology | ![]() positive regulation of AIM2 inflammasome complex assembly / cytolysis in another organism / positive regulation of pyroptotic inflammatory response / endopeptidase inhibitor activity / molecular function inhibitor activity / defense response to protozoan / protein localization to nucleus / cellular response to interleukin-1 / activation of innate immune response / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement ...positive regulation of AIM2 inflammasome complex assembly / cytolysis in another organism / positive regulation of pyroptotic inflammatory response / endopeptidase inhibitor activity / molecular function inhibitor activity / defense response to protozoan / protein localization to nucleus / cellular response to interleukin-1 / activation of innate immune response / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / cytoplasmic vesicle membrane / cellular response to type II interferon / Interferon gamma signaling / Interferon alpha/beta signaling / cellular response to tumor necrosis factor / cytoplasmic vesicle / cellular response to lipopolysaccharide / defense response to virus / defense response to Gram-positive bacterium / defense response to bacterium / immune response / Golgi membrane / GTPase activity / GTP binding / perinuclear region of cytoplasm / Golgi apparatus / protein homodimerization activity / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Cui, W. / Wang, W. / Chen, C. / Slater, B. / Xiong, Y. / Ji, X.Y. / Yang, H.T. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. Authors: Cui, W. / Braun, E. / Wang, W. / Tang, J. / Zheng, Y. / Slater, B. / Li, N. / Chen, C. / Liu, Q. / Wang, B. / Li, X. / Duan, Y. / Xiao, Y. / Ti, R. / Hotter, D. / Ji, X. / Zhang, L. / Cui, J. ...Authors: Cui, W. / Braun, E. / Wang, W. / Tang, J. / Zheng, Y. / Slater, B. / Li, N. / Chen, C. / Liu, Q. / Wang, B. / Li, X. / Duan, Y. / Xiao, Y. / Ti, R. / Hotter, D. / Ji, X. / Zhang, L. / Cui, J. / Xiong, Y. / Sauter, D. / Wang, Z. / Kirchhoff, F. / Yang, H. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 638 KB | Display | ![]() |
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PDB format | ![]() | 543.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 440 KB | Display | ![]() |
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Full document | ![]() | 446 KB | Display | |
Data in XML | ![]() | 36.1 KB | Display | |
Data in CIF | ![]() | 49.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7ckfC ![]() 7e59C ![]() 7e5aC ![]() 1f5nS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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