登録情報 | データベース: PDB / ID: 7ckf |
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タイトル | The N-terminus of interferon-inducible antiviral protein-dimer |
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要素 | Guanylate-binding protein 5 |
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キーワード | HYDROLASE / antiviral |
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機能・相同性 | 機能・相同性情報
positive regulation of AIM2 inflammasome complex assembly / symbiont cell surface / positive regulation of interleukin-18 production / protein localization to Golgi apparatus / cytolysis in another organism / positive regulation of pyroptotic inflammatory response / positive regulation of innate immune response / positive regulation of cytokine production involved in inflammatory response / positive regulation of NLRP3 inflammasome complex assembly / endopeptidase inhibitor activity ...positive regulation of AIM2 inflammasome complex assembly / symbiont cell surface / positive regulation of interleukin-18 production / protein localization to Golgi apparatus / cytolysis in another organism / positive regulation of pyroptotic inflammatory response / positive regulation of innate immune response / positive regulation of cytokine production involved in inflammatory response / positive regulation of NLRP3 inflammasome complex assembly / endopeptidase inhibitor activity / molecular function inhibitor activity / protein targeting / side of membrane / activation of innate immune response / positive regulation of interleukin-1 beta production / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / cytoplasmic vesicle membrane / cellular response to type II interferon / Interferon gamma signaling / cytoplasmic vesicle / cellular response to lipopolysaccharide / protein homotetramerization / defense response to virus / defense response to bacterium / inflammatory response / Golgi membrane / GTPase activity / GTP binding / perinuclear region of cytoplasm / Golgi apparatus / protein homodimerization activity / identical protein binding / membrane / cytoplasm類似検索 - 分子機能 Guanylate-binding protein, C-terminal / Guanylate-binding protein/Atlastin, C-terminal / Guanylate-binding protein, C-terminal domain / Guanylate-binding protein, N-terminal / Guanylate-binding protein, C-terminal domain superfamily / Guanylate-binding protein, N-terminal domain / GB1/RHD3-type guanine nucleotide-binding (G) domain / GB1/RHD3-type guanine nucleotide-binding (G) domain profile. / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 ALUMINUM FLUORIDE / GUANOSINE-5'-DIPHOSPHATE / Guanylate-binding protein 5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.284 Å |
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データ登録者 | Cui, W. / Yang, H.T. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 81772204 | 中国 |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2021 タイトル: Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. 著者: Cui, W. / Braun, E. / Wang, W. / Tang, J. / Zheng, Y. / Slater, B. / Li, N. / Chen, C. / Liu, Q. / Wang, B. / Li, X. / Duan, Y. / Xiao, Y. / Ti, R. / Hotter, D. / Ji, X. / Zhang, L. / Cui, J. ...著者: Cui, W. / Braun, E. / Wang, W. / Tang, J. / Zheng, Y. / Slater, B. / Li, N. / Chen, C. / Liu, Q. / Wang, B. / Li, X. / Duan, Y. / Xiao, Y. / Ti, R. / Hotter, D. / Ji, X. / Zhang, L. / Cui, J. / Xiong, Y. / Sauter, D. / Wang, Z. / Kirchhoff, F. / Yang, H. |
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履歴 | 登録 | 2020年7月16日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年5月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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