登録情報 データベース : PDB / ID : 7ank 構造の表示 ダウンロードとリンクタイトル Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with half dimer of alpha-actinin-2 要素(Alpha-actinin-2) x 2 Myozenin-1 詳細キーワード STRUCTURAL PROTEIN / Z-disk complex / F-actin crosslinking protein / scaffolding protein / fuzzy complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of skeletal muscle tissue regeneration / actin filament uncapping / FATZ binding / titin Z domain binding / phospholipase C-activating angiotensin-activated signaling pathway / skeletal muscle fiber adaptation / positive regulation of endocytic recycling / positive regulation of potassium ion transmembrane transporter activity / negative regulation of potassium ion transmembrane transporter activity / myofibril assembly ... negative regulation of skeletal muscle tissue regeneration / actin filament uncapping / FATZ binding / titin Z domain binding / phospholipase C-activating angiotensin-activated signaling pathway / skeletal muscle fiber adaptation / positive regulation of endocytic recycling / positive regulation of potassium ion transmembrane transporter activity / negative regulation of potassium ion transmembrane transporter activity / myofibril assembly / protein serine/threonine phosphatase inhibitor activity / telethonin binding / postsynaptic actin cytoskeleton / positive regulation of cation channel activity / negative regulation of protein localization to cell surface / LIM domain binding / microspike assembly / positive regulation of potassium ion transport / muscle cell development / focal adhesion assembly / Striated Muscle Contraction / Assembly and cell surface presentation of NMDA receptors / actinin binding / cardiac muscle cell development / Nephrin family interactions / negative regulation of calcineurin-NFAT signaling cascade / structural constituent of muscle / cortical actin cytoskeleton / sarcomere organization / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / pseudopodium / negative regulation of potassium ion transport / Long-term potentiation / postsynaptic density, intracellular component / skeletal muscle tissue development / titin binding / cytoskeletal protein binding / phosphatidylinositol-4,5-bisphosphate binding / Ras activation upon Ca2+ influx through NMDA receptor / nuclear receptor coactivator activity / platelet alpha granule lumen / molecular condensate scaffold activity / filopodium / cell projection / protein localization to plasma membrane / regulation of membrane potential / actin filament / postsynaptic density membrane / wound healing / Z disc / actin filament binding / actin cytoskeleton / integrin binding / Platelet degranulation / cell junction / actin binding / actin cytoskeleton organization / RAF/MAP kinase cascade / regulation of apoptotic process / transmembrane transporter binding / dendritic spine / cytoskeleton / cell adhesion / protein domain specific binding / focal adhesion / glutamatergic synapse / calcium ion binding / negative regulation of transcription by RNA polymerase II / extracellular exosome / extracellular region / identical protein binding / nucleus / cytosol 類似検索 - 分子機能 Myozenin / Calcineurin-binding protein (Calsarcin) / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. ... Myozenin / Calcineurin-binding protein (Calsarcin) / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Spectrin repeats / Actinin-type actin-binding domain, conserved site / Calponin homology domain / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / EF-hand domain pair / EF-hand, calcium binding motif / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.204 Å 詳細データ登録者 Sponga, A. / Arolas, J.L. / Rodriguez Chamorro, A. / Mlynek, G. / Hollerl, E. / Schreiner, C. / Pedron, M. / Kostan, J. / Ribeiro, E.A. / Djinovic-Carugo, K. 資金援助 オーストリア, 英国, 7件 詳細 詳細を隠す組織 認可番号 国 European Commission Marie Sklodowska-Curie Actions, ITN 238423 Austrian Science Fund I525, I1593, P22276, P19060 and W1221 オーストリア Christian Doppler Forschungsgesellschaft Laboratory for High-Content Structural Biology and Biotechnology オーストリア Wellcome Trust 201543/Z/16 英国 European Commission Austrian-Slovak Interreg Project B301 Vienna Science and Technology Fund (WWTF) Chemical Biology project LS17-008 オーストリア Research Platform Comammox オーストリア
引用ジャーナル : Sci Adv / 年 : 2021タイトル : Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with alpha-actinin.著者: Sponga, A. / Arolas, J.L. / Schwarz, T.C. / Jeffries, C.M. / Rodriguez Chamorro, A. / Kostan, J. / Ghisleni, A. / Drepper, F. / Polyansky, A. / De Almeida Ribeiro, E. / Pedron, M. / Zawadzka- ... 著者 : Sponga, A. / Arolas, J.L. / Schwarz, T.C. / Jeffries, C.M. / Rodriguez Chamorro, A. / Kostan, J. / Ghisleni, A. / Drepper, F. / Polyansky, A. / De Almeida Ribeiro, E. / Pedron, M. / Zawadzka-Kazimierczuk, A. / Mlynek, G. / Peterbauer, T. / Doto, P. / Schreiner, C. / Hollerl, E. / Mateos, B. / Geist, L. / Faulkner, G. / Kozminski, W. / Svergun, D.I. / Warscheid, B. / Zagrovic, B. / Gautel, M. / Konrat, R. / Djinovic-Carugo, K. 履歴 登録 2020年10月12日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年6月30日 Provider : repository / タイプ : Initial release改定 1.1 2024年1月31日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_residues Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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