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TitleOrder from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with alpha-actinin.
Journal, issue, pagesSci Adv, Vol. 7, Year 2021
Publish dateAug 31, 2020 (structure data deposition date)
AuthorsSponga, A. / Arolas, J.L. / Schwarz, T.C. / Jeffries, C.M. / Rodriguez Chamorro, A. / Kostan, J. / Ghisleni, A. / Drepper, F. / Polyansky, A. / De Almeida Ribeiro, E. ...Sponga, A. / Arolas, J.L. / Schwarz, T.C. / Jeffries, C.M. / Rodriguez Chamorro, A. / Kostan, J. / Ghisleni, A. / Drepper, F. / Polyansky, A. / De Almeida Ribeiro, E. / Pedron, M. / Zawadzka-Kazimierczuk, A. / Mlynek, G. / Peterbauer, T. / Doto, P. / Schreiner, C. / Hollerl, E. / Mateos, B. / Geist, L. / Faulkner, G. / Kozminski, W. / Svergun, D.I. / Warscheid, B. / Zagrovic, B. / Gautel, M. / Konrat, R. / Djinovic-Carugo, K.
External linksSci Adv / PubMed:34049882
MethodsX-ray diffraction
Resolution2.69 - 3.802 Å
Structure data

PDB-7a8t:
Crystal structure of sarcomeric protein FATZ-1 (mini-FATZ-1 construct) in complex with rod domain of alpha-actinin-2
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

PDB-7a8u:
Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with rod domain of alpha-actinin-2
Method: X-RAY DIFFRACTION / Resolution: 3.802 Å

PDB-7ank:
Crystal structure of sarcomeric protein FATZ-1 (d91-FATZ-1 construct) in complex with half dimer of alpha-actinin-2
Method: X-RAY DIFFRACTION / Resolution: 3.204 Å

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / Z-disk complex / F-actin crosslinking protein / scaffolding protein / fuzzy complex

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