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- PDB-6xcp: Immune receptor complex -

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ID or keywords:

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Basic information

Entry
Database: PDB / ID: 6xcp
TitleImmune receptor complex
Components
  • (T-CELL-RECEPTOR, A2.13- ...) x 2
  • Hybrid insulin peptide, MHC class II HLA-DQ8-beta chain fusion
  • MHC class II HLA-DQ-alpha chain
KeywordsIMMUNE SYSTEM / Complex
Function / homology
Function and homology information


antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / MHC class II protein complex / adaptive immune response / endosome membrane / lysosomal membrane
Similarity search - Function
MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. ...MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
PHOSPHATE ION / MHC class II HLA-DQ-beta-1 / MHC class II HLA-DQ-alpha chain
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.3 Å
AuthorsTran, T.M. / Faridi, P. / Lim, J.J. / Ting, T.Y. / Onwukwe, G. / Bhattacharjee, P. / Jones, M.C. / Tresoldi, E. / Cameron, J.F. / La-Gruta, L.N. ...Tran, T.M. / Faridi, P. / Lim, J.J. / Ting, T.Y. / Onwukwe, G. / Bhattacharjee, P. / Jones, M.C. / Tresoldi, E. / Cameron, J.F. / La-Gruta, L.N. / Purcell, W.A. / Mannering, I.S. / Rossjohn, J. / Reid, H.H.
Funding support Australia, 1items
OrganizationGrant numberCountry
National Health and Medical Research Council (NHMRC, Australia)APP1123586 Australia
CitationJournal: Nat Commun / Year: 2021
Title: T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8.
Authors: Tran, M.T. / Faridi, P. / Lim, J.J. / Ting, Y.T. / Onwukwe, G. / Bhattacharjee, P. / Jones, C.M. / Tresoldi, E. / Cameron, F.J. / La Gruta, N.L. / Purcell, A.W. / Mannering, S.I. / Rossjohn, J. / Reid, H.H.
History
DepositionJun 8, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jul 14, 2021Provider: repository / Type: Initial release
Revision 1.1Jan 26, 2022Group: Database references / Category: citation / citation_author / database_2
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.2Oct 18, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: MHC class II HLA-DQ-alpha chain
C: Hybrid insulin peptide, MHC class II HLA-DQ8-beta chain fusion
D: T-CELL-RECEPTOR, A2.13-alpha chain
E: T-CELL-RECEPTOR, A2.13-beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)98,4708
Polymers97,8414
Non-polymers6294
Water63135
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area13420 Å2
ΔGint-65 kcal/mol
Surface area36380 Å2
Unit cell
Length a, b, c (Å)65.977, 116.788, 124.187
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number19
Space group name H-MP212121
Space group name HallP2ac2ab
Symmetry operation#1: x,y,z
#2: x+1/2,-y+1/2,-z
#3: -x,y+1/2,-z+1/2
#4: -x+1/2,-y,z+1/2

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Components

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Protein , 2 types, 2 molecules AC

#1: Protein MHC class II HLA-DQ-alpha chain


Mass: 21929.256 Da / Num. of mol.: 1 / Mutation: I72C
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Tissue: Skin, lymphoid, lungs, stomach and intestines / Cell: B Lymphocytes, dendritic cells, macrophages / Gene: HLA-DQA1 / Organ: Parenchyma / Plasmid: pZip3 / Cell line (production host): High Five (BTI-Tn-5B1-4) / Organ (production host): ovary / Production host: Trichoplusia ni (cabbage looper) / Strain (production host): DH10B / References: UniProt: Q30069
#2: Protein Hybrid insulin peptide, MHC class II HLA-DQ8-beta chain fusion / HIP


Mass: 26070.969 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Tissue: Islets of Langerhans / Cell: Beta cells / Organ: Pancreas / Plasmid: pZip3 / Gene: HLA-DQB1 / Cell line (production host): High Five (BTI-Tn-5B1-4) / Organ (production host): ovary / Production host: Trichoplusia ni (cabbage looper) / Strain (production host): DH10B / References: UniProt: O19707

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T-CELL-RECEPTOR, A2.13- ... , 2 types, 2 molecules DE

#3: Protein T-CELL-RECEPTOR, A2.13-alpha chain


Mass: 22633.219 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Tissue: Islets of Langerhans / Cell: Beta cells / Gene: TRAV26-1*01 / Organ: Pancreas / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3)
#4: Protein T-CELL-RECEPTOR, A2.13-beta chain


Mass: 27207.289 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Tissue: Islets of Langerhans / Cell: Beta cells / Gene: TRBV5-1*01 / Organ: Pancreas / Plasmid: pET30 / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3)

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Sugars , 1 types, 2 molecules

#5: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 3 types, 37 molecules

#6: Chemical ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C3H8O3
#7: Chemical ChemComp-PO4 / PHOSPHATE ION


Mass: 94.971 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: PO4
#8: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 35 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.49 Å3/Da / Density % sol: 50.68 %
Crystal growTemperature: 293.15 K / Method: vapor diffusion, hanging drop / Details: 13% PEG 8000, 0.2M Potassium dihydrogen phosphate

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Australian Synchrotron / Beamline: MX2 / Wavelength: 0.9537 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Mar 7, 2019
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9537 Å / Relative weight: 1
ReflectionResolution: 3.3→43.73 Å / Num. obs: 15005 / % possible obs: 99.87 % / Redundancy: 2 % / Biso Wilson estimate: 79.38 Å2 / CC1/2: 0.994 / CC star: 0.998 / Rmerge(I) obs: 0.0686 / Rpim(I) all: 0.0686 / Rrim(I) all: 0.09701 / Net I/σ(I): 8.46
Reflection shellResolution: 3.3→3.418 Å / Rmerge(I) obs: 0.4183 / Mean I/σ(I) obs: 1.58 / Num. unique obs: 1466 / CC1/2: 0.994 / CC star: 0.93 / Rpim(I) all: 0.4183 / Rrim(I) all: 0.5916 / % possible all: 100

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Processing

Software
NameVersionClassification
PHENIX1.15_3459refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 4Z7U

4z7u


Resolution: 3.3→43.73 Å / SU ML: 0.4033 / Cross valid method: FREE R-VALUE / σ(F): 1.35 / Phase error: 25.9851
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2683 754 5.03 %
Rwork0.2343 14242 -
obs0.2359 14996 99.93 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 77.91 Å2
Refinement stepCycle: LAST / Resolution: 3.3→43.73 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6268 0 39 35 6342
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00196476
X-RAY DIFFRACTIONf_angle_d0.50028845
X-RAY DIFFRACTIONf_chiral_restr0.0438988
X-RAY DIFFRACTIONf_plane_restr0.00381155
X-RAY DIFFRACTIONf_dihedral_angle_d17.69382274
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
3.3-3.550.29481690.28782761X-RAY DIFFRACTION99.97
3.55-3.910.29631490.26292809X-RAY DIFFRACTION99.97
3.91-4.480.28491370.21242839X-RAY DIFFRACTION100
4.48-5.640.22711460.20722851X-RAY DIFFRACTION100
5.64-43.730.26611530.24032982X-RAY DIFFRACTION99.75
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.87604467638-0.298283295232-1.650115348921.62791450044-1.054076671723.538742046552.12950154239-0.367637239378-0.176338207111-0.433416445989-0.770490688313-0.1708922725630.417063823632-1.047187378950.5029892891280.38181362-0.2326318854130.1994273323850.6464936389010.3328543925190.85399618442510.2336262094216.825943568139.630379119
20.6029461963880.4378121788960.9099151196132.852677086332.111348288943.067268172570.378622631994-0.192995048725-0.4979900154070.328666720042-0.242354085848-0.879396995266-0.1521352207640.4528953395820.1754924902680.711561202308-0.0456200751213-0.0347770341570.555744588280.08720837850790.94303046237526.9405876408215.113581309137.718268794
35.35872828772.14745700405-0.5074162152690.871118769028-0.2075179187260.671693064671-0.9826924111591.28499748111-0.708064139267-0.5522087553081.41357719318-1.451769068060.738716781656-0.3101730149450.3126576850670.931595749631-0.0920017045609-3.31052096848E-50.488435496567-0.03406026540440.99179299977521.576604343210.710238488125.67330255
42.996546628370.252526802607-0.7522042829413.21372192514-0.7998747481934.21899903060.199063841816-0.44700812979-0.134457234360.881869471614-0.54640668546-0.104108872571-1.025849072950.285066798770.1673106228650.646455057428-0.0102299558262-0.09609324102050.3571557842330.07273872482520.62698683700927.5519883452225.700033093148.355765583
52.33369124821.127668337640.2651374188533.04906848554-2.418677662052.62425194344-0.587418882525-0.630716250422-0.235333361750.5714647128440.9368973130690.34341259301-0.7001762611491.476373885690.411161575391.070954740030.0503060528318-0.03095054446760.549073091350.1108126384970.98544443004721.5664423105192.325921446145.096741573
60.411594118071.19801588945-0.5158506541814.17171802577-1.840739125951.97297847577-0.12168209825-1.18503116008-0.9789985795381.652020615250.633510945679-1.233189849220.2374645091511.331734074670.5163748122190.8100855789750.114070712809-0.1747759552270.5199509219180.2185218080051.1010250423829.4589478224204.758859112150.986876367
70.6423753634420.42420967186-0.5487612287041.3944248515-0.4178376065470.6022308533960.426675027231-0.695745238051.380316214481.57683829984-1.29458898894-1.94696763168-0.0565871625904-0.690428656620.5734729293820.7772921695210.190080426303-0.001169883356120.799124810809-0.05330530160141.3117358838534.9185749875195.173556204144.380895272
82.541040040212.014167759241.142406942043.353297983020.2218494927115.64934448703-0.347340798707-0.3142410353230.453904788414-0.197534138565-0.9334473352630.519965780489-0.59210083751-1.314746686190.1071485700790.802616897240.115505199656-0.1547440559890.402695602757-0.03393137794331.0314699598420.0345194926212.011596628147.259574602
90.362030154061.430827985140.2775753985934.201569059030.9231376292510.201330472139-0.5559291431450.1097696390340.279003125165-0.0949359716903-0.00791994490668-1.305591526370.8724274504831.133645199410.3041860428030.9600952889310.356812823271-0.04203674891740.6032398760880.1770502031931.2664032669928.4439282227192.316384154146.484468838
101.20509333470.071565721525-0.2979141391793.49278046342-0.5173888184150.992462768489-0.3143951134250.1505368373390.6520273884510.326672103878-0.3153870749080.2758433381320.5869606755310.4774850774090.3815753388831.282257723820.0622428751666-0.1567183072470.6992737036470.3293129155371.0552861219528.1002134042199.349194139157.111824121
111.876870615921.52179419699-1.449517573284.8561954250.1525551283692.532199017350.17387169274-0.450501830547-0.04293412055020.634760560309-0.356511556807-0.1952222006510.3938129871240.491237726530.09126034639420.642202818228-0.0542489048536-0.06187811827340.3910054492690.1191381561920.78832633473622.5269697468221.176687368148.333670193
121.875429713410.704402743044-0.6869857076231.969785839250.004604820285932.971182057830.56725413777-0.6876922498920.0322453411680.262857245792-0.209656427366-0.1853431997480.324528617055-0.545613247272-0.03347418775940.747002960520.07928982350260.04374673943020.4298354180860.06119302542150.76734272320311.242974244226.501419982144.985630307
135.96268114841.671579286021.425056689143.08270173741-2.319863818413.152929740121.15156116989-0.8123073854281.78470505474-0.6547784740170.236868308673-0.57910344686-0.48629758478-0.255533715623-0.04248802099820.797474688206-0.04077447879930.06686093708420.4350264376820.04877878328530.92024696460716.6265669348239.164148263145.583068267
141.660009163611.462910120081.662420456181.968481056762.588906716763.48512575097-0.0155373867416-0.275342187030.833515518604-0.754447141035-1.376282620850.2990883790340.586569065678-0.0293953389786-0.6999608625390.9826203164590.212497704309-0.02134890634390.3971309795550.1990061513731.0762595632812.994552332233.603335641133.513459183
150.8285213680671.25088972091-0.3843784848211.90576166473-0.5136827937380.2804144679190.0653657086372-0.6455714272960.483415943366-1.98340114990.9772889595861.27413303847-1.3891760219-0.216100837751-0.008571368860981.06504813340.0288957579719-0.06893732299260.546706239093-0.02973715277940.8254599353310.2396233442217.576215549126.973422263
160.6348475368431.51139548092-0.818118503851.86095170917-1.14491130630.173357704129-1.012610469730.005488332940290.12062928454-1.265916437781.07466392424-0.2269527992690.937695549635-0.7551598585570.3701981360081.134276156810.005004936298880.05134726107240.447555881281-0.0223102498750.8696056457369.37795545847190.385597276138.57227077
171.26682131615-0.00489138490035-0.3238141750964.17618004644-2.188674994530.875269833325-0.5716651476770.838074113445-0.1079431562690.3652253451620.347391523730.7256027429-0.293910381116-0.7363227267010.09086404653130.964816916264-0.02603541013070.05181279627740.572082060854-0.01803303602260.9377673327480.420251388895190.206521574143.550345936
181.647570967082.10514494105-0.8972230995382.54074935171-0.4607425392812.011988752070.137210684734-0.3832515730550.173244443981-0.482878963865-0.720124040718-0.3198534471390.5089147186410.4135462295930.273973045460.7397244754090.01753366607790.106585544850.54324798490.1070073347060.92343101360110.9034833441195.032334854144.033456046
191.521087537121.452912312850.2479234745554.87258763582-1.498911596554.001549158590.07539488570120.103602598453-0.1353290496860.241102100054-0.2588272393751.019745875590.2504500199860.92483115911-0.0169778660851.09204659797-0.1693237970430.3657805761850.287533618486-0.08526814286081.01753027620.638625412671181.941581717139.462768135
200.9485376922940.383361571163-1.032875948322.82707497818-1.324228653151.388454450060.214738264420.6422904704170.18640710516-0.869160211816-0.6090527253820.826307298613-1.46745392578-0.427520120725-0.01225933914240.7540602659020.115778732343-0.01360986237960.6403899389980.07036902021080.81803654968619.971735116224.042950256129.752502173
210.2575669299140.486139770526-0.3600498127320.834043655739-0.7989076145012.466289426340.5172762258590.572661476661.277299159090.3832455427680.0552809585095-1.768742463440.7897184770770.2044934671810.02527144816140.1496891175420.11468515008-0.4152618957351.35735451816-0.5655689794871.2495736678527.8756736362237.907900782146.596518745
223.34002663024-0.653885243515-0.1882390785325.31051770187-1.067804235531.532155450890.0482769399780.2587231739460.30993952701-0.474519775117-0.129096594881-0.04411793031310.09608514141-0.114998252441-0.1361616428580.5260840265380.0194029683670.0501564556670.5197437245960.1054404713680.68519706358517.5529376422242.217214911115.641897329
231.683817535740.1970882067260.09036210340813.45141337902-0.497229459472.650967714320.2710857287030.0320847787492-0.1852386666620.159079107287-0.1575230120860.2400592394030.288734398759-0.229891734188-0.09733531597410.551968267436-0.0413659597285-0.1058371539270.5017060862990.02989365431660.78502593893517.6870103244240.872914155115.946789297
24-0.143183587192-0.2791359176870.2417014286892.63835549653-1.296448195080.854342124757-0.1392753718930.1491046230540.209453563381-0.07812313968320.5456575049030.613230716590.5443365549520.0167381099766-0.2226198721880.736343522044-0.00865085525834-0.1163406281340.466444710950.01631250840860.97684714946828.553696304269.13082905598.991625544
252.46806467254-0.0514360098694-0.3232979460942.23791211428-0.1633484538882.47225651289-2.187829956261.5217024749-2.199633830820.1987983055350.0300924267728-0.404591268099-0.715823776158-1.69166505496-0.1452668443651.61138683556-0.2672905584160.007893069431651.20129868546-0.4837507759991.6449139313230.1343981841260.17810520493.7919488923
265.034470826080.9186377654912.374120273772.70581756818-1.161004647051.85776665474-0.2780367036110.1896581198810.3061575766510.4055080893030.0154461157563-0.05777664784770.494631656249-0.0167538450801-0.2665081619980.8267411482360.02420380199350.07012102013870.4764270696510.130190255660.79856812261630.8046548978266.56527070897.9372595427
273.515257348960.0548685950192-0.2660927442623.28540863575-0.002023806506182.591335626030.232898776461-0.0869452414501-0.2783978905310.2128816205720.000671214824294-0.438419451250.2110643423610.09527794754380.2110088569790.483186205590.0264901575956-0.1072231637970.4166975206420.1660562436470.82595471504339.3464038688240.036367166127.710892567
281.993827730910.218757836563-0.1455089756793.71242676411-0.4806114129670.617549773113-0.167483984959-0.0165559903225-0.374062581215-0.369705186152-0.252802186326-0.7709773125110.134827365747-0.01566362074340.2748018145660.517812593358-0.0275074855353-0.0339145049240.491033604950.06695146165160.87567298768141.4573414826244.447373518121.390829427
290.255863649423-0.943627907341-0.6016859877982.509551091450.443830222340.829540140304-0.0353474355901-0.0969828022703-0.3146608204560.22078240550.07709137003960.371946905369-0.371170308299-0.182646081865-0.09052338473480.655006300134-0.0003312998806640.02923875086850.4419394231950.09474446998060.84712529859536.6265786543270.708037587106.811122495
300.9076265170361.312036790380.4580797173933.346617177791.707306767412.177773298160.245027802393-0.0302732260612-0.4628149545310.00520759487702-0.01419083720310.2958909273660.2282586064910.14421076281-0.03812156011490.750243169908-0.0345294675655-0.02945936724560.5061523027190.09069114188410.75412673044936.471024108265.441565252107.706641708
311.04075120824-0.464169347735-1.118927977975.68710920824-1.724044499191.83767079958-0.179018214902-1.24389158879-0.00785673584024-0.1768559082011.18779369710.105069065221-0.866022848380.00747183478921-0.1140836081270.762720238558-0.0385450562020.03820253147980.726583181681-0.04657660158130.79461912143137.9078199894277.072848556114.13899525
322.72238747269-0.4105815490051.668978933915.68137646379-0.7388434837232.656821050190.537791012392-0.4012518869-0.475181595117-0.511173812588-0.445844528492-0.433292661274-0.287225757950.4324399043030.3640134055040.263490393207-0.1106555709050.03097349895240.810523704039-0.05018440350111.0381393836551.0199109171265.939837867115.194765371
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'A' and (resid 0 through 11 )AA0 - 111 - 13
22chain 'A' and (resid 12 through 43 )AA12 - 4314 - 45
33chain 'A' and (resid 44 through 55 )AA44 - 5546 - 57
44chain 'A' and (resid 56 through 87 )AA56 - 8758 - 89
55chain 'A' and (resid 88 through 110 )AA88 - 11090 - 112
66chain 'A' and (resid 111 through 123 )AA111 - 123113 - 125
77chain 'A' and (resid 124 through 134 )AA124 - 134126 - 136
88chain 'A' and (resid 135 through 146 )AA135 - 146137 - 148
99chain 'A' and (resid 147 through 166 )AA147 - 166149 - 168
1010chain 'A' and (resid 167 through 180 )AA167 - 180169 - 182
1111chain 'C' and (resid 30 through 43 )CC30 - 431 - 14
1212chain 'C' and (resid 44 through 81 )CC44 - 8115 - 52
1313chain 'C' and (resid 82 through 91 )CC82 - 9153 - 62
1414chain 'C' and (resid 92 through 104 )CC92 - 10463 - 75
1515chain 'C' and (resid 105 through 115 )CC105 - 11576 - 86
1616chain 'C' and (resid 116 through 147 )CC116 - 14787 - 111
1717chain 'C' and (resid 148 through 171 )CC148 - 171112 - 135
1818chain 'C' and (resid 172 through 190 )CC172 - 190136 - 154
1919chain 'C' and (resid 191 through 219 )CC191 - 219155 - 183
2020chain 'C' and (resid -2 through 7 )CC-2 - 71 - 10
2121chain 'C' and (resid 8 through 14 )CC8 - 1411 - 17
2222chain 'D' and (resid 2 through 76 )DD2 - 761 - 59
2323chain 'D' and (resid 77 through 120 )DD77 - 12060 - 103
2424chain 'D' and (resid 121 through 152 )DD121 - 152104 - 136
2525chain 'D' and (resid 153 through 167 )DD153 - 167137 - 151
2626chain 'D' and (resid 168 through 217 )DD168 - 217152 - 189
2727chain 'E' and (resid 3 through 86 )EE3 - 861 - 71
2828chain 'E' and (resid 87 through 133 )EE87 - 13372 - 118
2929chain 'E' and (resid 134 through 171 )EE134 - 171119 - 156
3030chain 'E' and (resid 172 through 211 )EE172 - 211157 - 196
3131chain 'E' and (resid 212 through 224 )EE212 - 224197 - 209
3232chain 'E' and (resid 225 through 254 )EE225 - 254210 - 239

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