- PDB-6w4m: CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV... -
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Database: PDB / ID: 6w4m
Title
CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1
Components
ANTI-HIV ANTIBODY N12-I2 FAB HEAVY CHAIN
ANTI-HIV ANTIBODY N12-I2 FAB LIGHT CHAIN
M48U1 CD4 MIMETIC PEPTIDE
clade A/E 93TH057 HIV-1 gp120 core
Keywords
VIRAL PROTEIN/IMMUNE SYSTEM / ADCC AND NEUTRALIZING ANTI-HIV-1 ENV ANTIBODY N12-I2 / CD4I ANTIBODY / FAB FRAGMENT / HIV-1 GP120 / IMMUNE SYSTEM / CLADE A/E 93TH057 / VIRAL PROTEIN-IMMUNE SYSTEM COMPLEX
Mass: 39160.367 Da / Num. of mol.: 1 / Mutation: H375S Source method: isolated from a genetically manipulated source Source: (gene. exp.) Human immunodeficiency virus 1 / Gene: HIV-1 Env / Cell (production host): HEK 293 GnT1- / Production host: Homo sapiens (human) / References: UniProt: A0A0M3KKW9
#2: Antibody
ANTI-HIVANTIBODYN12-I2FABLIGHTCHAIN
Mass: 23437.988 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell (production host): HEK 293 / Production host: Homo sapiens (human)
#3: Antibody
ANTI-HIVANTIBODYN12-I2FABHEAVYCHAIN
Mass: 25810.697 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell (production host): HEK 293 / Production host: Homo sapiens (human)
#4: Protein/peptide
M48U1CD4MIMETICPEPTIDE
Mass: 3056.804 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) synthetic construct (others)
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